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Detlef Schuppan
Detlef Schuppan, born 1954, is a German physician-scientist known for identifying tissue transglutaminase as the celiac autoantigen and developing the first TG2 inhibitor in trials.
Detlef Weigel
Detlef Weigel, born 1961 in Germany, is a plant biologist directing the Max Planck Institute for Biology Tübingen, known for LEAFY, FT, and the 1001 Genomes Project.
Detlev Arendt
Detlev Arendt is a German evolutionary biologist and molecular neurobiologist who leads a group at EMBL Heidelberg, known for reconstructing the nervous system of the last common ancestor of bilaterian animals.
Detlev Bronk
Detlev Wulf Bronk (1897–1975) was an American biophysicist who recorded electrical activity in single motor nerve fibers and served as president of Johns Hopkins and Rockefeller University.
Detoxification
Detoxification, also called biotransformation, is the set of metabolic reactions by which the body chemically alters foreign compounds such as drugs, reducing toxicity and easing excretion.
Detoxification foot baths
Detoxification foot baths, also called ionic foot baths or foot detox, are pseudoscientific devices claimed to pull toxins through the feet; studies, including a 2012 IonCleanse trial, find no detox effect, and water color change comes from electrode corrosion.
Detoxification of Reactive Oxygen Species
Detoxification of Reactive Oxygen Species (Reactome R-HSA-3299685) is a curated human pathway in which superoxide dismutases, catalase, peroxiredoxins, and glutathione peroxidases convert superoxide and hydrogen peroxide to water and oxygen.
Detransition
Detransition: stopping or reversing a gender transition, medical or social. Reported rates range from about 1% surgical regret to 0-9.8% after hormones; definitions and measurement vary widely.
Detritivore
Detritivores are invertebrates such as earthworms, termites, and millipedes that feed on dead organic matter or its microbes, raising decomposition rates by about 50% on average and anchoring brown food webs.
Detritus
Detritus is dead organic matter (leaf litter, carrion, faeces, exudates) forming the brown, detrital food web; most primary production, over 80% on land, passes through it, and it acts as both resource and habitat.
Detroit 562
Detroit 562 (CVCL_1171, ATCC CCL-138) is a human pharyngeal squamous cell carcinoma cell line from a female patient's metastatic pleural effusion; HPV-negative, TP53 R175H and PIK3CA H1047R mutant, widely used HNSCC model.
Detroit 6
Detroit 6 (Det-6, CVCL_2436) is a human cancer cell line described in 1956 as sternal marrow from a male lung carcinoma patient but shown by Gartler and later work to be a HeLa derivative carrying HPV18.
Detumomab
Detumomab (Specifid, formerly FavId) is a mouse monoclonal antibody against human B-cell lymphoma cells, an investigational Favrille candidate for follicular non-Hodgkin's lymphoma that reached Phase 3 but was never approved.
Deubiquitinating enzyme inhibitors and drug targeting
Deubiquitinating enzyme inhibitors are small molecules blocking the roughly 110 human enzymes that remove ubiquitin tags from proteins, pursued mainly for cancer therapy with none approved.
Deubiquitination
Deubiquitination is the removal of ubiquitin tags from proteins by about 100 human deubiquitinating enzymes (DUBs) in seven families, mostly cysteine proteases, regulating degradation, DNA repair, immunity, and emerging drug targets.
Deuremidevir hydrobromide
Deuremidevir hydrobromide (VV116, JT001; 民得维, Mindvy) is an oral nucleoside analog RdRp inhibitor, a remdesivir/GS-441524 derivative, approved in China and Uzbekistan for mild-to-moderate COVID-19.
Deutenzalutamide soft capsules
Deutenzalutamide soft capsules (氘恩扎鲁胺软胶囊, Haina'an, HC-1119) are Hinova Pharmaceuticals' deuterated enzalutamide analog, an androgen receptor inhibitor approved in China in May 2025 for mCRPC after abiraterone and chemotherapy, dosed 80 mg daily.
Deuterium metabolic imaging
Deuterium metabolic imaging (DMI) is a magnetic resonance technique that maps metabolism in living tissue by administering deuterium-labeled glucose and imaging its conversion into products like lactate.
Deuterostome
Deuterostomia: bilaterian animals (chordates, hemichordates, echinoderms, xenoturbellids) whose blastopore becomes the anus and mouth forms secondarily; molecular support for the clade is equivocal.
Devadarvadi kvatha curna
Devadarvadi kvatha curna (Devadārvādi kvātha cūrṇa), AFI formulation AFI000561, is a 21-ingredient Ayurvedic coarse-powder decoction formula led by Cedrus deodara, dosed at 48 g in divided doses per the Ayurvedic Formulary of India.
Devadarvarista
Devadarvarista (Devadārvāriṣṭa, AFI000326) is a classical Ayurvedic fermented arishta around Cedrus deodara wood, from Bhaishajya Ratnavali, dosed 12–24 ml, mainly indicated for prameha (diabetes).
Devascularization (surgery)
Devascularization is a surgical technique that deliberately cuts or removes the blood supply to an organ or tissue, most often to stop bleeding from gastroesophageal varices or postpartum hemorrhage.
Development of the digestive system
Development of the digestive system: embryology of the primitive gut tube from definitive endoderm, foregut/midgut/hindgut derivatives, HOX and SHH patterning, midgut rotation, recanalization, and organoid models.
Development of the embryonic venous system
The embryonic venous system consists of three paired networks, vitelline, umbilical, and cardinal, that are remodeled from about 4 weeks into the adult vena cavae, portal vein, and right atrium.
Development of the face
Development of the face: embryology of facial formation from five prominences (frontonasal, maxillary, mandibular) in weeks 4 to 8, driven by neural crest cells, WNT/BMP/FGF/SHH signaling, and studied via mouse, chick, zebrafish, and frog models.
Development of the human spinal cord
The human spinal cord develops from the neural tube in the fourth week of embryonic life, then ascends within the vertebral canal to end near L1 in adults.
Development of the nervous system in humans
Development of the human nervous system (neurulation): neural tube and neural crest form from ectoderm 2–3 weeks after conception; tube becomes CNS, crest builds PNS; synapses peak at ~150% adult levels in infancy.
Development of the reproductive system
Development of the reproductive system: embryology of gonads, genital ducts, external genitalia, and gonadal descent from intermediate mesoderm. Indifferent stage until week 7; SRY, testosterone, and AMH drive male differentiation; female pathway is hormone-independent.
Development of the thymus
Development of the thymus describes how the thymus arises from the third pharyngeal pouch, descends to the chest, is colonized by T cell precursors, and undergoes fat replacement after puberty.
Development of the urinary system
Development of the urinary system: embryonic formation of kidneys, ureters, bladder, and urethra via pronephros, mesonephros, and metanephros stages, ureteric bud branching morphogenesis, nephron induction, and CAKUT malformations.