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Double-stranded DNA deaminase immunity protein DddI

DddI (DddA immunity protein, UniProt P0DUH6) is a 123-aa Burkholderia cenocepacia immunity protein that inhibits the dsDNA deaminase toxin DddA by DNA mimicry, blocking its active site in a 1:1 complex (PDB 6U08).

Double-stranded RNA viruses

Double-stranded RNA viruses, also called dsRNA viruses, are viruses with double-stranded RNA genomes, forming Baltimore class III; rotaviruses are a leading cause of severe childhood diarrhea.

Doubled haploidy

Doubled haploidy, or the doubled haploid technique, is a plant breeding method that creates completely homozygous lines in two generations, widely used in maize, wheat, barley, and rice.

Doublet chemotherapy

Doublet chemotherapy is a cancer treatment that combines two cytotoxic drugs given together in the same treatment cycles, the standard first-line backbone for advanced colorectal cancer with regimens such as FOLFOX or FOLFIRI.

Doubly labeled water

Doubly labeled water (DLW) is an isotope tracer method measuring total energy expenditure in free-living people, regarded as the gold standard since the first human study in 1982.

Douche

Douche: rinsing the inside of the vagina with water, vinegar, baking soda, or iodine solutions. Practiced by 29-92% of women worldwide, mainly for cleanliness; linked to bacterial vaginosis, PID, and preterm birth; not recommended by health authorities.

Doug Waterhouse

Doug Waterhouse (1916–2000) was an Australian entomologist who led CSIRO's Division of Entomology for 21 years and identified the active ingredients of the insect repellent Aerogard.

Douglas A. Bayliss

Douglas A. Bayliss is a neuroscientist and pharmacologist who chairs Pharmacology at the University of Virginia, known for identifying how the brain's carbon dioxide sensors control breathing.

Douglas A. Corley

Douglas A. Corley is an American gastroenterologist and researcher at Kaiser Permanente's Northern California Division of Research, known for his 2014 study linking adenoma detection rates to colorectal cancer risk.

Douglas A. Lauffenburger

Douglas A. Lauffenburger is an American biological engineer at MIT who founded and chaired its Department of Biological Engineering and was named an Institute Professor in 2026.

Douglas Argyll Robertson

Douglas Argyll Robertson (1837–1909) was a Scottish ophthalmic surgeon who described the Argyll Robertson pupil, a classic sign of neurosyphilis, and served as surgeon-oculist to Queen Victoria.

Douglas B. Cines

Douglas B. Cines was an American hematologist and professor at the University of Pennsylvania whose research shaped the understanding and treatment of immune thrombocytopenia and heparin-induced thrombocytopenia.

Douglas C. Dean

Douglas C. Dean is a molecular biologist holding an endowed chair at the University of Louisville, known for Cell papers on the retinoblastoma protein and later research on retinitis pigmentosa.

Douglas C. Rees

Douglas C. Rees (D.C. Rees) is an American structural biochemist, the Roscoe Gilkey Dickinson Professor of Chemistry at Caltech, known for the first crystal structure of nitrogenase.

Douglas C. Wallace

Douglas C. Wallace is an American mitochondrial geneticist who founded the field of human mitochondrial genetics, showing that mtDNA is inherited only from the mother.

Douglas C. Youvan

Douglas C. Youvan is an American biophysicist who sequenced the bacterial photosynthetic reaction-center genes, engineered its amino acids to alter electron transfer, and co-founded Kairos Scientific.

Douglas D. Bannerman

Douglas D. Bannerman is an American immunologist whose USDA Beltsville research defined how cows' innate immunity responds to mastitis, earning the 2006 Presidential Early Career Award.

Douglas D. Richman

Douglas D. Richman is an American virologist and physician at UC San Diego, known for the first identification of HIV drug resistance and landmark antiretroviral therapy trials.

Douglas E. Soltis

Douglas E. Soltis, born in 1953, is an American plant biologist at the Florida Museum of Natural History known for work on flowering plant evolution and polyploidy.

Douglas Easton

Douglas F. Easton is a British genetic epidemiologist, Professor at the University of Cambridge, who characterized cancer predisposition genes like BRCA1 and created the BOADICEA risk prediction model.

Douglas fir

Douglas fir (Pseudotsuga menziesii), also called Oregon-pine or Douglas-spruce, is a major western North American timber conifer that is not a true fir; two varieties, coast and Rocky Mountain, range from 19° to 55° N.

Douglas G. Capone

Douglas G. Capone, also known as Douglas Capone, is an American oceanographer and USC professor known for research showing that marine microbes fix nitrogen in the open ocean.

Douglas H. Erwin

Douglas H. Erwin, born 1958, is an American paleobiologist at the Smithsonian National Museum of Natural History known for work on the end-Permian mass extinction.

Douglas H. Turner

Douglas H. Turner, born 1946, is an American chemist at the University of Rochester whose Turner rules let software predict RNA secondary structure from sequence alone.

Douglas Hanahan

Douglas Hanahan is an American cancer biologist best known for the "Hallmarks of Cancer" framework, and professor emeritus at EPFL in Lausanne and a Ludwig Institute Distinguished Scholar.

Douglas Higgs

Douglas Higgs (Douglas R. Higgs) is a British clinician-scientist at Oxford who directed the MRC Molecular Haematology Unit and is known for unraveling the molecular genetics of alpha-thalassaemia.

Douglas Houghton Campbell

Douglas Houghton Campbell (1859–1953) was an American botanist who studied the morphology of mosses, liverworts, and ferns, and headed Stanford University's botany department from 1891 to 1925.

Douglas J. Futuyma

Douglas J. Futuyma (born 1942) is an American evolutionary biologist, Distinguished Professor Emeritus at Stony Brook University, known for research on speciation in herbivorous insects and the textbook Evolution.

Douglas J. Winton

Douglas J. Winton is a British cancer biologist at the University of Cambridge who studies intestinal stem cells and the earliest steps of bowel cancer.

Douglas K Owens

Douglas K Owens is an American physician and health economist at Stanford University and the VA Palo Alto, known for cost-effectiveness analyses of HIV screening and implantable defibrillators.