72,234 articles
E. Roy John
E. Roy John (Erwin Roy John, 1924–2009) was an American neuroscientist who pioneered neurometrics, a quantitative EEG method, co-discovered the P300 evoked potential, and founded NYU's Brain Research Laboratories.
E. Russell Alexander
E. Russell Alexander is an American physician and epidemiologist at the University of Washington whose 1975 and 1978 New England Journal of Medicine studies helped define chlamydial disease.
E. Tessa Hedley‐Whyte
E. Tessa Hedley-Whyte, also known as E. T. Hedley-Whyte, is a British-born American neuropathologist and Harvard Medical School professor of pathology at Massachusetts General Hospital.
E. Toby Kiers
E. Toby Kiers, also published as Toby Kiers, is an American-born evolutionary biologist at Vrije Universiteit Amsterdam known for showing that legumes sanction cheating rhizobia.
E. Wesley Ely
E. Wesley Ely (Eugene Wesley Ely) is an American critical-care physician-scientist at Vanderbilt University Medical Center who developed the CAM-ICU delirium screening tool and helped define long Covid.
E. Yvonne Jones
E. Yvonne Jones is a British structural biologist at Oxford who determines cell-surface signaling structures and has been a Fellow of the Royal Society since 2017.
E. Zachary Nussbaum
E. Zachary Nussbaum, also known as Eliezer Zachary Nussbaum, is an American physician in Boston known for co-authoring 2023 New England Journal of Medicine case records.
E.A. Caspary
E.A. Caspary is an immunologist who worked with the Medical Research Council in Newcastle upon Tyne and proposed the macrophage electrophoretic mobility test as a diagnostic test for cancer.
E.B. Keverne
E.B. Keverne, also known as Eric B. Keverne, is a British behavioral neuroscientist at the University of Cambridge, known for work on pheromones and genomic imprinting in brain development.
E.C. HUSKISSON
E.C. Huskisson was a British rheumatologist at St Bartholomew's Hospital whose 1974 Lancet paper "Measurement of Pain" established how pain should be measured in clinical trials.
E.C. Slater
E.C. Slater, born Edward Charles Slater, was an Australian-born biochemist (1917–2016) who spent 1955–1985 at the University of Amsterdam, known for the chemical theory of oxidative phosphorylation.
E.F. Pai
Emil F. Pai is a German-born structural biologist and X-ray crystallographer who moved to the University of Toronto in 1991 and solved the first flavoenzyme and oncoprotein structures.
E.H. Eylar
E.H. Eylar, also known as Edwin H. Eylar, is a biochemist known for sequencing myelin basic protein and mapping the nine-residue site that induces experimental allergic encephalomyelitis.
E1 N-terminal domain
E1 N-terminal domain refers to several unrelated protein regions: the colicin E1 TolA-binding translocation domain, the papillomavirus E1 regulatory region, the HCV E1 ectodomain, the APP E1 domain, the MeCP2-E1 NTD, and ubiquitin-activating enzyme E1's NTD.
E2 binding
E2_bind (SMART SM001181, InterPro IPR014929) is a ubiquitin-like E2-binding domain on the NEDD8-activating E1 enzyme that recruits the E2 Ubc12 during neddylation.
E2F Family
The E2F family (E2F1–E2F8) is a group of transcription factors controlling cell cycle, apoptosis, and differentiation genes, regulated by RB pocket proteins, with activator (E2F1–3a) and repressor (E2F3b–8) classes.
E2F1
E2F1 (E2F transcription factor 1, gene ID 1869) is the founding member of the E2F transcription factor family, an RB-regulated activator driving G1/S cell-cycle genes, DNA repair, and apoptosis, with dual oncogenic and tumor-suppressive roles in cancer.
E2F2
E2F2 (E2F transcription factor 2, HGNC:3114) is a human activator E2F transcription factor that binds DP proteins and pRB, controls G1/S cell cycle progression, and acts as tumor suppressor in T cell lymphoma but oncogene in ovarian cancer.
E2F3
E2F3 (E2F transcription factor 3, HGNC:3115, 6p22.3) is a human gene encoding an E2F family cell-cycle transcription factor that binds pRB and DP proteins; it produces two isoforms, growth-regulated E2F3a and constitutive E2F3b, essential for proliferation and myogenic differentiation.
E2F4
E2F4 (E2F transcription factor 4), gene at human 16q22.1, is a repressive E2F family member that binds all three RB-family pocket proteins and, in the DREAM complex with p130 and the MuvB core, represses about 1000 cell cycle genes in G0; it also regulates cilia, adipogenesis, and stem cell differentiation.
E3 Ubiquitin ligase MUL1-like domain
E3 ubiquitin ligase MUL1-like domain (InterPro IPR022170): a modified C3HC5-type RING finger in mitochondrial outer-membrane ligase MUL1 (MULAN/MAPL/GIDE/HADES), which ubiquitinates MFN2, p53, AKT, ULK1 and SUMOylates Drp1, regulating mitochondrial dynamics, mitophagy, and apoptosis.
E3 ubiquitin-protein ligase
E3 ubiquitin-protein ligase (ubiquitin ligase, E3): enzyme conferring substrate specificity in the E1-E2-E3 ubiquitination cascade. Classes RING, HECT, RBR, U-box; over 600 human E3s; targets of PROTACs and molecular glues.
E3 ubiquitin-protein ligase CHFR
CHFR (checkpoint with forkhead-associated and RING finger domains, RNF196) is a human E3 ubiquitin ligase and antephase mitotic checkpoint protein; its loss by promoter hypermethylation is a diagnostic and prognostic biomarker in colorectal, gastric, and other cancers.
E3 ubiquitin-protein ligase FANCL
FANCL (PHF9, FA complementation group L) is the RING-type E3 ubiquitin ligase of the Fanconi anemia core complex; with E2 UBE2T it monoubiquitinates FANCD2 K561 and FANCI K523 for interstrand cross-link repair.
E3 ubiquitin-protein ligase HOS1
HOS1 (HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENES 1) is an Arabidopsis RING finger E3 ubiquitin ligase that attenuates cold signaling by degrading ICE1, delays flowering by degrading CONSTANS, and acts non-proteolytically in FLC chromatin regulation, nuclear pore mRNA export, and circadian control.
E3N study
E3N (Étude Épidémiologique auprès de femmes de la MGEN) is a French prospective cohort of 98,995 women born 1925–1950, followed since 1990; French component of EPIC, studying lifestyle, diet, environment, and women's health, with the E3N-Générations family extension.
E4 protein
E4 protein (E1^E4), a late papillomavirus protein encoded within the E2 ORF; abundant in upper epithelium, binds and disrupts keratin, induces G2 arrest, aids genome amplification and virus release, and serves as an HPV infection biomarker.
EAGeR trial
EAGeR (Effects of Aspirin in Gestation and Reproduction) trial: NICHD-funded randomized trial of preconception 81 mg aspirin in 1,228 women with 1-2 prior pregnancy losses; no overall live birth benefit, subgroup benefit in single recent loss.
Eagle
Eagle: large birds of prey mainly in Accipitridae (with hawks and kites), in sea, snake, harpy, and booted eagle groups; includes bald, golden, Philippine, and extinct Haast's eagles.
Eagle eye
Eagle eye: the eye of eagles and other raptors, with 2-2.5x human visual acuity, two foveae, up to 1 million photoreceptors/mm², and a telephoto optical design; also a figurative term and an unconfirmed autism hypothesis.