edgepedia

Life and health

72,234 articles

Eran Halperin

Eran Halperin is a computational biologist and statistical geneticist who develops machine learning methods for genomic data, and since 2026 has been a professor at New York University's Courant Institute.

Eran Pichersky

Eran Pichersky is a plant biochemist and emeritus professor at the University of Michigan known for research on how plants make volatile scent and flavor compounds.

Eran Segal

Eran Segal is an Israeli computational biologist, born in Tel Aviv in 1973, who is a professor at the Weizmann Institute of Science known for personalized nutrition research.

Eranda Paka

Eranda Paka (Eraṇḍa pāka) is an official Ayurvedic semisolid avaleha confection of castor (Ricinus communis) cooked with milk, sugar, ghee, and herbs, from Yogratnakara, AFI Part II 3:3, dose 5–15 g, used for Vata disorders and constipation.

ERAP1

ERAP1 (ERAAP, ARTS-1), endoplasmic reticulum aminopeptidase 1, is an IFN-γ-induced M1 aminopeptidase that trims MHC-I peptide precursors via a molecular ruler preferring 9–16-residue substrates with hydrophobic C termini; a disease-associated polymorphic enzyme distinct from ERAP2.

ERAP2

ERAP2 (endoplasmic reticulum aminopeptidase 2, LRAP) is a human 5q15 zinc aminopeptidase trimming MHC-I peptide precursors; splice-site SNP rs2248374 silences it in ~25% of people, and haplotype A links to autoimmunity and Black Death survival.

ERAS trial

ERAS trial (NCT05511194): single-blind randomized trial of a modified Enhanced Recovery After Surgery protocol for pediatric complicated appendicitis in Guadalajara, Mexico; 40 children; shorter stay (3.15 vs 5.20 days) without added morbidity.

ERAS-0015

JYP0015 (ERAS-0015, JYP-0015) is an oral pan-RAS molecular glue from Guangzhou JOYO Pharma, licensed to Erasca, in Phase 1/2 trials for RAS-mutant pancreatic, lung, and colorectal cancers.

ERAS-4001

ERAS-4001 is Erasca's oral pan-KRAS inhibitor, in-licensed from Medshine Discovery, that binds mutant and wild-type KRAS while sparing HRAS/NRAS; it is in the BOREALIS-1 Phase 1 trial (NCT07021898) for KRAS-mutant solid tumors, with monotherapy data expected in H2 2026.

Erasmus Darwin

Erasmus Darwin (1731–1802), English physician, poet, inventor, and Lunar Society founder; grandfather of Charles Darwin. Proposed evolution from 'one living filament' in Zoonomia (1794–96) and wrote The Botanic Garden; declined George III as patient.

Erasmus MC

Erasmus MC (Erasmus University Medical Center Rotterdam) is the university medical center of Erasmus University Rotterdam, formed in 2002-2003 from Dijkzigt Hospital, Sophia Children's Hospital, the Daniel den Hoed Clinic, and the medical faculty; the Netherlands' largest medical research center.

Eratigena

Eratigena, anagram of Tegenaria, is a genus of Agelenidae funnel-web spiders erected by Bolzern, Burckhardt and Hänggi in 2013; type species the giant house spider Eratigena atrica, also including the hobo spider E. agrestis.

Eratigena atrica

Eratigena atrica, the Giant House Spider (formerly Tegenaria atrica), a large European funnel-web spider (Agelenidae) introduced to North America; type species of genus Eratigena, split into three species in 2018.

Eratrectinib

Anrotinib (Willcell TRK inhibitor) denotes eratrectinib (安瑞曲替尼, VC004, brand Weimaituo), Jiangsu Vcare's next-generation pan-TRKA/B/C inhibitor for NTRK fusion solid tumors, conditionally approved in China June 2026 at 50 mg twice daily.

Eravacycline

Eravacycline (Xerava) is a fully synthetic fluorocycline tetracycline antibiotic approved in 2018 for complicated intra-abdominal infections in adults, dosed 1 mg/kg IV every 12 hours, with activity against multidrug-resistant Gram-negative bacteria but not cUTI.

Erb's palsy

Erb paralysis (Erb's palsy, Erb-Duchenne paralysis) is upper-arm weakness from C5–C6 upper trunk brachial plexus injury, mostly at birth; ~90% of neonatal brachial plexus palsies, often with shoulder dystocia, usually recovering in 3–4 months.

ERBB2

ERBB2, also called HER2 or neu, is a human chromosome 17 gene encoding an EGFR-family receptor tyrosine kinase; its amplification defines HER2-positive breast cancer and drove trastuzumab development.

ERBB3

ERBB3 (HER3, erb-b2 receptor tyrosine kinase 3), 12q13.2, is a kinase-impaired ERBB family receptor binding neuregulins, signaling via ERBB2 heterodimers and PI3K/Akt, and driving cancer and resistance.

ERBB4

ERBB4 (HER4) is a human ERBB-family receptor tyrosine kinase gene at 2q34 with seven ligands, four splice isoforms, nuclear intracellular-domain signaling, and an ambiguous, context-dependent role in cancer.

ERBIN

ERBIN (ERBB2IP, LAP2) is a human LAP-family scaffold gene at 5q12.3 whose PDZ-domain protein binds unphosphorylated ERBB2/HER2, stabilizes it via HSP90, and regulates Ras and TGF-beta signaling.

ERCC1

ERCC1, or excision repair cross complementation group 1, is a human gene on chromosome 19 encoding a subunit of the ERCC1-XPF enzyme that repairs DNA damage, first cloned in 1984.

ERCC2

ERCC2 (XPD) is a human gene on chromosome 19 encoding a 761-amino-acid TFIIH helicase used in transcription initiation and nucleotide excision repair; mutations cause xeroderma pigmentosum, trichothiodystrophy, and overlap syndromes, and somatic mutations mark cisplatin-sensitive bladder cancer.

ERCC3

ERCC3 (XPB) is a human gene on chromosome 2q14.3 encoding an ATP-dependent 3'-5' DNA helicase subunit of TFIIH, essential for transcription initiation and nucleotide excision repair; mutations cause xeroderma pigmentosum group B, Cockayne syndrome, and trichothiodystrophy.

ERCC4

ERCC4 (XPF, FANCQ) is a human gene on 16p13.12 encoding the catalytic subunit of the ERCC1-XPF structure-specific endonuclease, which makes the 5' incision in nucleotide excision repair and interstrand crosslink repair; mutations cause XP group F, Fanconi anemia group Q, and XFE progeroid syndrome.

ERCC6

ERCC6 (CSB), gene at 10q11.23 encoding a SWI/SNF ATP-dependent chromatin remodeler that initiates transcription-coupled nucleotide excision repair; biallelic mutations cause Cockayne syndrome type B, COFS, and UV-sensitive syndrome.

Ercha Shangqing Pills

Ercha Shangqing Wan (儿茶上清丸, Jingmen Shangqing Wan) is a Category 1.1 innovative traditional Chinese medicine pill by Hubei Qijin Pharmaceutical, approved January 2024 (Z20240001) for mild recurrent aphthous ulcers with upper-jiao heat syndrome.

Erdafitinib

Erdafitinib (Balversa) is an oral pan-FGFR kinase inhibitor for metastatic urothelial carcinoma with susceptible FGFR3 alterations after prior therapy including a PD-1/PD-L1 inhibitor; THOR showed survival benefit over chemotherapy.

Erdheim–Chester disease

Erdheim-Chester disease (ECD), a rare clonal non-Langerhans histiocytic neoplasm first described in 1930, causes foamy histiocyte infiltration of bones and organs, with BRAF V600E mutations in 50-60% and MAPK-inhibitor therapy.

Erdong Tang

二冬汤 (Erdong Tang) is a Qing-era classic Chinese medicine formula from Cheng Guopeng's Yixue Xinwu, built on tian dong and mai dong, for upper-wasting diabetes; approved as Erdong Tang granules, a 2024 category-3.1 new drug.

Erdosteine

Erdosteine, a thiol-based mucoactive prodrug (N-(carboxymethylthioacetyl)-homocysteine thiolactone) activated to metabolite M1, treats acute and chronic pulmonary disease; RESTORE showed reduced COPD exacerbation rate and duration.