Life and health

EPOOzo-2 study

EPOOzo-2 (NCT07325851) is a prospective observational study of 120 patients receiving palliative ozone therapy at Dr. Negrín University Hospital's Chronic Pain Unit, Gran Canaria, Spain, 2026-2029, measuring quality of life.

Epothilone

Epothilone, a 16-membered macrolide from Sorangium cellulosum So ce90, stabilizes microtubules like paclitaxel; its lactam analogue ixabepilone (Ixempra) is FDA-approved for breast cancer.

Epoxiconazole

Epoxiconazole: systemic triazole (DMI, FRAC 3) fungicide, C17H13ClFN3O, inhibiting fungal CYP51; first registered 1993 by BASF, EU approval expired 30 April 2020; used on cereals against Septoria, rusts, Fusarium head blight.

Epoxide hydrolase

Epoxide hydrolase (EH; mEH/EPHX1, sEH/EPHX2) is a cofactor-independent enzyme family that hydrolyzes epoxides to vicinal diols via an Asp-His-Asp/Glu triad and covalent intermediate; sEH is a drug target for hypertension, inflammation, and pain.

EPPO Code

EPPO Codes are 5-6 letter unique identifiers for plants and pests in agriculture and plant protection, developed by Bayer in the 1970s and maintained by EPPO since 1996; over 98,500 species coded as of June 2025.

Epratuzumab

Epratuzumab (AMG 412, hLL2, LymphoCide) is a humanized anti-CD22 IgG1 monoclonal antibody with partial B-cell depletion, tested in SLE through phase III EMBODY trials, which failed, leaving it unapproved.

Oct 20, 2026

Eprenetapopt

Eprenetapopt (APR-246, PRIMA-1MET) is an investigational small-molecule p53 reactivator prodrug converted to methylene quinuclidinone; developed by Aprea Therapeutics for TP53-mutant MDS/AML, its phase 3 trial missed its primary endpoint and it is not FDA approved.

Epristeride

Epristeride (爱普列特) is a noncompetitive 5α-reductase inhibitor for benign prostatic hyperplasia, developed in China, approved as a class-1 new drug in 1999, and marketed by Lianhuan Pharmaceutical.

Eprodisate

Eprodisate (Kiacta, Fibrillex, NC-503; 1,3-propanedisulfonic acid disodium salt) is an investigational sulfonated inhibitor of amyloid fibril polymerization for AA amyloidosis kidney disease; its first phase 3 trial was positive but a confirmatory trial failed and it was never approved.

Eprosartan

Eprosartan (Teveten) is a non-biphenyl, non-tetrazole angiotensin II receptor blocker for hypertension, dosed 600-800 mg daily, selective for the AT1 receptor and not metabolized by cytochrome P450.

Eprotirome

Eprotirome (KB2115), a liver-selective thyroid hormone receptor beta agonist from Karo Bio, lowered LDL cholesterol, triglycerides, and Lp(a) in trials but was abandoned after canine cartilage damage and liver injury ended its phase 3 AKKA trial.

Epsilon-polylysine

Epsilon-polylysine (ε-PL, ε-poly-L-lysine) is a cationic homopolymer of 25–35 L-lysine residues made by Streptomyces albulus, used as a broad-spectrum natural antimicrobial food preservative; FDA GRAS under GRN 135 and 336.

Epstein-Barr virus-associated gastric carcinoma

Epstein-Barr virus-associated gastric carcinoma (EBVaGC), EBV-positive gastric cancer, is a molecular subtype of gastric carcinoma defined by latent EBV in tumor cells, about 8-10% of cases, male-predominant, proximal, with favorable prognosis and PD-L1 expression.

Epstein-Barr virus-positive diffuse large B-cell lymphoma

EBV-positive diffuse large B-cell lymphoma (EBV+ DLBCL, NOS), formerly EBV+ DLBCL of the elderly, is an aggressive EBV-carrying B-cell lymphoma of patients over 50 without immunodeficiency, diagnosed by EBER, treated with R-CHOP, with worse prognosis than EBV-negative DLBCL.

Epstein–Barr virus

Epstein–Barr virus (EBV, human herpesvirus 4) is a γ-herpesvirus spread by saliva that infects over 90% of adults, causes infectious mononucleosis, and was the first virus linked to human cancer, including Burkitt lymphoma and nasopharyngeal carcinoma.

Eptacog alfa (activated)

Eptacog alfa (activated), brand NovoSeven/NovoSeven RT (Novo Nordisk), is recombinant activated factor VIIa, a bypassing agent for bleeding in hemophilia with inhibitors, factor VII deficiency, and Glanzmann's thrombasthenia; EU/US approvals 1996/1999, EU shortages through 2025.

EPTC

EPTC (S-ethyl dipropylthiocarbamate, Eptam, Eradicane) is a thiocarbamate herbicide, CAS 759-94-4, registered in the US in 1958, applied pre-emergence with soil incorporation, acting by VLCFA synthesis inhibition (HRAC Group 15).

Oct 15, 2026

Eptifibatide

Eptifibatide (brand name Integrilin) is a synthetic cyclic heptapeptide drug that inhibits platelet aggregation by blocking the glycoprotein IIb/IIIa receptor, approved in 1998 for acute coronary syndrome and coronary intervention.

Eptinezumab

Eptinezumab (Vyepti, ALD403, eptinezumab-jjmr) is a humanized anti-CGRP monoclonal antibody given as a 100 or 300 mg intravenous infusion every 12 weeks to prevent migraine in adults; FDA approved February 2020, developed by Alder and acquired by Lundbeck.

Eptotermin alfa

Eptotermin alfa (rhBMP-7, OP-1) is a recombinant bone morphogenetic protein used as an implantable bone-graft substitute; EU brands Osigraft (tibial non-union) and Opgenra (spinal fusion) were withdrawn in 2015–2016.

EpVAr2019 study

EpVAr2019 (NCT04107467), a prospective multicenter observational study of mechanical ventilation epidemiology in Argentine ICUs, Sept-Dec 2019; 950 patients, 142 units; ICU mortality 44.6%, hospital 47.9%.

Epworth Sleepiness Scale

The Epworth Sleepiness Scale is a self-administered questionnaire rating dozing likelihood in eight everyday situations, scored 0-24, introduced by Murray Johns in 1991 and widely used in sleep medicine.

EQ-5D

The EQ-5D is a standardized, self-administered questionnaire measuring health-related quality of life across five dimensions, developed by the EuroQol Group and widely used for computing QALYs in health technology assessment.

eQTL analysis

eQTL analysis is a genetic mapping method that treats gene expression levels as quantitative traits, identifying DNA variants that regulate gene expression and helping interpret GWAS signals.

eQTL mapping

eQTL mapping is a statistical genetics method that tests inherited DNA variants for association with gene expression, producing catalogs of variant–gene pairs that regulate transcript abundance.

Equatorin

Equatorin, encoded by the EQTN gene also called SPACA8 or C9orf11, is a membrane glycoprotein found only in sperm, where it enables the acrosome reaction and fertilization.

Equecabtagene autoleucel

Equecabtagene autoleucel (伊基奥仑赛, Fucaso) is a fully human BCMA-directed autologous CAR-T therapy by IASO Bio, conditionally approved by China's NMPA on June 30, 2023 for relapsed/refractory multiple myeloma after at least three prior lines.

Equianalgesic

Equianalgesic dose: an opioid dose giving pain relief equivalent to a reference dose, usually oral or parenteral morphine. Tables guide opioid rotation but ratios vary, are unidirectional, and require 25–50% dose reduction for incomplete cross-tolerance.

Equidae

Equidae, the horse family, is one of three living perissodactyl families: horses, donkeys, asses, and zebras, all in genus Equus. Originated in North America about 55.5 MYA; seven living species, several threatened.