72,234 articles
Fazamorexant
Fazamorexant (YZJ-1139, brand Mengping) is a dual orexin receptor antagonist for insomnia developed by Yangtze River Pharmaceutical, approved in China on 21 May 2026 as the first domestically developed DORA, with IC50 32/41 nM and half-life about 2–4 hours.
Fazirsiran
Fazirsiran (TAK-999, ARO-AAT) is an investigational siRNA therapy by Arrowhead and Takeda that degrades Z-AAT mRNA to treat alpha-1 antitrypsin deficiency liver disease; phase 2 trials showed ~94% liver Z-AAT reduction and fibrosis regression.
FB825
FB825 is a humanized monoclonal antibody developed by Oneness Biotech to treat IgE-related allergic diseases such as atopic dermatitis and allergic asthma, out-licensed to LEO Pharma in 2020.
FBL
FBL (fibrillarin, HGNC:3599; synonyms FIB, FLRN, NOP1) is a human chromosome 19q13.2 gene encoding the nucleolar 2'-O-methyltransferase catalytic core of box C/D snoRNPs, essential for rRNA methylation, ribosome biogenesis, and linked to scleroderma autoimmunity and cancer; distinct from Drosophila fbl (fumble, pantothenate kinase).
FBLN5
FBLN5 (fibulin 5, DANCE, EVEC) is a human gene at 14q32.12 encoding a 66-kDa extracellular matrix protein essential for elastic fiber assembly; mutations cause cutis laxa and are linked to macular degeneration.
FBN2
FBN2 (fibrillin 2) is a protein-coding gene at 5q23.3 encoding the microfibril protein fibrillin-2; pathogenic variants cause congenital contractural arachnodactyly (Beals syndrome), an autosomal dominant Marfan-like connective tissue disorder.
FBXO32
FBXO32 (MAFbx, atrogin-1), human F-box protein 32 on chromosome 8, is the substrate adaptor of an SCF E3 ubiquitin ligase highly expressed in atrophying skeletal and cardiac muscle, with tumor-suppressive and oncogenic roles in cancer.
FBXW7
FBXW7 (FBW7, hCDC4) is a tumor suppressor gene at 4q32 encoding the substrate receptor of an SCF E3 ubiquitin ligase that degrades oncoproteins including cyclin E, MYC, NOTCH, and MCL1; it is frequently mutated in cancers via hotspot arginine missense changes.
Fc receptor
Fc receptor: cell-surface protein binding the Fc region of antibodies (FcγRI/CD64, FcγRII/CD32, FcγRIII/CD16, FcεRI, FcαRI/CD89, FcµR, FcRn). Mediates phagocytosis, ADCC, degranulation via ITAM/ITIM signaling; FcγRIIb is the sole inhibitory Fcγ receptor.
FCGR1A
FCGR1A (CD64, Fc gamma receptor Ia) is a human gene on chromosome 1q21.2 encoding FcγRI, the sole high-affinity human IgG Fc receptor, with three extracellular domains and pseudogenes FCGR1B and FCGR1C.
FCGR2A
FCGR2A is a human gene on chromosome 1q23.3 encoding Fc gamma receptor IIa (CD32a), found on immune cells and platelets, with the widely studied H131R polymorphism.
FCGR2B
FCGR2B (CD32B) is the human gene for FcγRIIb, the only inhibitory low-affinity IgG Fc receptor, carrying an ITIM motif. Its I232T polymorphism (rs1050501) is linked to SLE, and its isoforms b1 and b2 serve B-cell inhibition and immune complex endocytosis.
FCGR3A
FCGR3A (Fc gamma receptor IIIa, CD16a, FcγRIIIa) is a human gene on 1q23.3 encoding a low-affinity activating IgG Fc receptor on NK cells and macrophages that mediates ADCC; its V158F polymorphism (rs396991) alters IgG binding and therapeutic antibody response.
FCGR3B
FCGR3B (CD16b, HNA-1) is a human gene at 1q23.3 encoding FcγRIIIb, a GPI-anchored low-affinity IgG Fc receptor on neutrophils; it varies in copy number (0–4 copies), carries HNA-1 allotypes NA1/NA2, and low copy number raises SLE risk.
FCLADHAAASDFSQ trial
FCLADHAAASDFSQ (NCT07376148) is a phase 4, single-group, open-label trial at Instituto de Oftalmología Fundación Conde de Valenciana, Mexico City, testing topical hyaluronic acid, ascorbic acid, and sodium DNA after fractional CO2 laser for photoaged facial skin in 30 participants, with SASSQ as the primary outcome.
FCN-338 (LOXO-338)
FCN-338 (LOXO-338, LY3847429) is an oral selective BCL-2 inhibitor developed by Fochon Pharmaceuticals (Fosun Pharma), licensed to Eli Lilly in 2020, discontinued by Lilly in 2022, and still in Phase I/II trials in China.
FD-SAC BAS study
FD-SAC BAS (NCT07754188) is a prospective real-world cohort study at three Chinese centers comparing 30-day stroke or death after flow diverter versus stent-assisted coiling in 274 patients with unruptured wide-neck bifurcation aneurysms.
Fe del Mundo
Fe del Mundo (1911-2011), Filipina pediatrician and first woman National Scientist of the Philippines; founded the country's first pediatric hospital (1957), researched dengue and childhood vaccines, invented a bamboo incubator.
Fear of cancer
Fear of cancer (carcinophobia, ICD-11 MG24.0) ranges from common population cancer worry to clinical nosophobia, illness anxiety disorder, and fear of cancer recurrence in survivors; treated with CBT.
Fear of cardiovascular disease
Fear of cardiovascular disease, known as cardiophobia or heart-focused anxiety, is a specific phobia involving repeated chest pain and palpitations with fear of heart attack, classified as ICD-11 code MG24.7.
Fear of death or dying
Fear of death or dying (death anxiety), ICD-11 code MG23, is fear of one's own and others' mortality; a transdiagnostic construct linked to anxiety, depression, and hypochondriasis, measured mainly by the Templer Death Anxiety Scale.
Fear of disease
Fear of disease is excessive anxiety about having or acquiring illness. It includes nosophobia, fear of one specific disease, and illness anxiety disorder, the DSM-5 name for hypochondria.
Fear of flying
Fear of flying (aerophobia, aviophobia) is a situational specific phobia affecting an estimated 10–40% of people, about 25 million U.S. adults. Treated mainly with exposure-based CBT and virtual reality exposure therapy.
Fear of human immunodeficiency virus
Fear of human immunodeficiency virus (ICD-11 MG24.1), also called HIV phobia, serophobia, or AIDS phobia, is a classified disease-fear condition: persistent, irrational fear of contracting HIV despite negative tests, first described 1983, closely tied to HIV stigma and testing anxiety.
Fear of mental disorder
Fear of mental disorder (ICD-11 MG24.J) is a chapter 24 category classifying fear of developing a mental disorder as a health-status factor, distinct from hypochondriasis (6B23) and bodily distress disorder, alongside sibling disease-fear codes.
Fear of the dark
Fear of the dark, clinically nyctophobia (also scotophobia, lygophobia), is a specific phobia of darkness causing panic, insomnia, and avoidance; common in children, treated with CBT and exposure therapy.
Feather
Feather: branched beta-keratin skin appendage unique to birds and their dinosaur ancestors, built from calamus, rachis, barbs, and interlocking barbules; first feathers were simple filaments, with origin timing still debated.
Feather mite
Feather mites are mites that live permanently on the feathers and skin of birds, feeding on fungi, bacteria, preen oil, and debris. About 2,500 species are described, mostly harmless.
Feathered dinosaur
Feathered dinosaurs: non-avian dinosaurs with feathers or protofeathers, first proven by Sinosauropteryx (Liaoning, 1996) and Archaeopteryx (1861). Feathers concentrate in coelurosaur theropods; earliest dinosaurs were probably scaly; feathers served insulation, display and camouflage before flight.
Feature barcoding
Feature barcoding is a single-cell genomics method in which DNA-barcoded antibodies are sequenced alongside mRNA, quantifying surface proteins and sample identity with gene expression; CITE-seq is the best-known implementation.