519,064 articles
Apraclonidine
Apraclonidine (Iopidine) is a selective alpha-2 adrenergic agonist eye drop, a para-amino clonidine derivative approved in 1987 to prevent post-laser IOP spikes and in 1993 for short-term glaucoma therapy; tachyphylaxis limits chronic use.
APRAN study
APRAN study (NCT02556034), a Canadian validation trial by Fortin et al. testing whether trained rheumatology nurses can assess RA and PsA disease activity (CDAI, DAS-28) as accurately as rheumatologists; nurse-physician DAS-28 correlation r=0.846.
Aprataxin and PNK-like factor
APLF (aprataxin and PNK-like factor, PALF, Xip1, C2orf13) is a human DNA repair protein with an FHA domain and tandem PBZ motifs, acting in NHEJ, single-strand break repair, histone chaperoning, and replication fork protection.
Apraxia
Apraxia is a brain condition in which someone cannot perform a requested voluntary movement despite normal muscle function, comprehension, and willingness, often after a stroke.
Apraxia of speech
Apraxia of speech (AOS), also called verbal apraxia, is a motor speech disorder impairing planning of speech movements, caused by stroke, injury, or neurodegeneration, and distinguished from aphasia and dysarthria by absent weakness and language deficits.
Aprecia Pharmaceuticals
Aprecia Pharmaceuticals is a privately held pharmaceutical company in Langhorne, Pennsylvania, using its ZipDose 3D printing to make SPRITAM, the first FDA-approved 3D-printed drug product.
Apremilast
Apremilast (Otezla) is an oral phosphodiesterase 4 inhibitor approved in 2014 for plaque psoriasis and psoriatic arthritis, also used for Behçet's oral ulcers; dosed 30 mg twice daily after titration.
Apreo Health
Apreo Health is a privately held medical device company founded in 2021 in Menlo Park, California, developing the BREATHE Airway Scaffold, a bronchoscopic nitinol implant for severe emphysema.
Aprepitant
Aprepitant (Emend) is a substance P/neurokinin-1 receptor antagonist antiemetic first approved in 2003 to prevent chemotherapy-induced and postoperative nausea and vomiting; oral 125/80/80 mg dosing, CYP3A4 interactions, IV Aponvie since 2022.
Apres-Ski
Apres-Ski is German-language party music played in Alpine ski huts after a day on the slopes: simple singalong schlager, party evergreens, and club music, with DJ Ötzi as its defining star.
Apricitabine
Apricitabine (ATC; formerly AVX754, SPD754, BCH10618) is an investigational deoxycytidine analogue NRTI for HIV-1, active against M184V and thymidine analogue mutation virus; Avexa halted its phase III development in 2010 without approval.
Apricot
Apricot (Prunus armeniaca), a Rosaceae stone fruit from Central Asia with two domestication events; Turkey leads fresh production (1.27 Mt, 2024) and Türkiye dominates dried apricots; kernels contain toxic amygdalin.
Apricot kernel
Apricot kernel (Prunus armeniaca seed, amygdalin, laetrile, vitamin B17): seed inside the apricot pit; contains amygdalin that releases cyanide; no evidence it treats cancer; sale restricted in AU/NZ and EU.
Apries
Apries, also known as Hophra, was a pharaoh of Egypt's Twenty-sixth Dynasty who reigned from 589 to 570 BC and was overthrown by his general Amasis.
April
April (Aprel) is the fourth month of the Gregorian calendar, with 30 days, marking spring in the Northern Hemisphere and fall in the Southern Hemisphere.
April (2024 film)
April (Aprili) is a 2024 Georgian-French-Italian drama by Dea Kulumbegashvili, her second feature after Beginning. Obstetrician Nina (Ia Sukhitashvili) is investigated after a stillbirth while secretly performing illegal abortions; it won the Venice Special Jury Prize.
April (에이프릴) (girl group)
APRIL (에이프릴) was a South Korean girl group under DSP Media, debuting August 24, 2015 with Dreaming and disbanding January 28, 2022 after a bullying controversy; final lineup Chaekyung, Chaewon, Naeun, Yena, Rachel, Jinsol.
April 1
April 1, the 91st day of the Gregorian year (92nd in leap years), is April Fools' Day worldwide and also Assyrian New Year (Kha b-Nisan), Cyprus National Day, Iran's Islamic Republic Day, and Odisha Day in India.
April 1 Vidudala (ఏప్రిల్ 1 విడుదల)
April 1 Vidudala (ఏప్రిల్ 1 విడుదల), also April 1st Vidudala, is a 1991 Telugu comedy directed by Vamsy, starring Rajendra Prasad and Shobana, with Ilaiyaraaja's music, based on the novel Harischandrudu Abaddhamaadithe, released 1 February 1991.
April 10
April 10 is the 100th day of the year in common years, the anniversary of the 1815 Mount Tambora eruption and the 1998 Good Friday Agreement.
April 11
April 11, the 101st day of the year (102nd in leap years), is the calendar date of Napoleon's 1814 abdication and Treaty of Fontainebleau, the 1900 USS Holland submarine purchase, Buchenwald's 1945 liberation, MacArthur's 1951 dismissal, the 1961 Eichmann trial, and the 1970 Apollo 13 launch.
April 12
April 12, the 102nd day of the year, marks Yuri Gagarin's 1961 first human spaceflight (Cosmonautics Day), the 1861 Fort Sumter attack that began the US Civil War, FDR's 1945 death, and Columbia's 1981 first shuttle launch.
April 12 Incident
The April 12 Incident (四一二政变), also called the Shanghai massacre, was a purge in Shanghai on 12 April 1927 in which Jiang Jieshi's forces attacked Communists, marking the Nationalist–Communist split.
April 13
April 13, the 104th day of leap years, is marked by Fort Sumter's 1861 surrender, the 1919 Jallianwala Bagh massacre, Apollo 13's 1970 oxygen tank explosion, Jefferson's 1743 birth, Songkran, and the US observance of Thomas Jefferson's Birthday.
April 14
April 14, the 104th day of the year, is marked by Lincoln's 1865 assassination at Ford's Theatre, the Titanic's 1912 iceberg collision, Webster's 1828 dictionary, and Indian Ambedkar Jayanti and Vaisakhi observances.
April 15
April 15, the 105th day of the Gregorian year and US Tax Day, marks Lincoln's 1865 death, the 1912 Titanic sinking, Jackie Robinson's 1947 MLB debut, the 1989 Hillsborough disaster, and the 2019 Notre Dame fire.
April 16
April 16, the 106th day of the Gregorian year, is a calendar date marked by events such as Lenin's 1917 return, the 1947 Texas City disaster, the 1963 Letter from Birmingham Jail, the 1972 Apollo 16 launch, and the 2007 Virginia Tech shooting, plus observances like Emancipation Day in Washington, D.C.
April 17
April 17, the 107th day of the Gregorian year (108th in leap years), is marked by the 1521 Diet of Worms, the 1961 Bay of Pigs invasion, the 1970 Apollo 13 splashdown, the 1975 fall of Phnom Penh, and World Hemophilia Day.
April 18
April 18, the 108th day of the Gregorian year, is International Day for Monuments and Sites, World Amateur Radio Day, and Zimbabwe Independence Day; historically it marks Paul Revere's 1775 ride and the 1906 San Francisco earthquake.
April 19
April 19, the 109th day of the year, is the date of the Battles of Lexington and Concord (1775), the first Boston Marathon (1897), the Warsaw Ghetto Uprising (1943), the Waco siege fire (1993), and the Oklahoma City bombing (1995).