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Tlön, Uqbar, Orbis Tertius
Tlön, Uqbar, Orbis Tertius is a 1940 short story by Jorge Luis Borges, first published in Sur and collected in Ficciones (1944), about a secret society's encyclopedia of an invented planet that gradually replaces reality.
TLR1
TLR1 (toll-like receptor 1, CD281, TIL), gene at 4p14, is a human pattern-recognition receptor that dimerizes with TLR2 to recognize triacylated bacterial lipopeptides such as Pam3CSK4, signaling via MyD88 and NFκB; the I602S variant rs5743618 impairs trafficking and protects against leprosy.
TLR4
TLR4 (toll-like receptor 4, CD284) is the human innate immune receptor for bacterial LPS and endogenous danger signals, the only TLR using both MyD88 and TRIF pathways, gene at 9q33.1.
TLR5
TLR5 (toll-like receptor 5), human gene at 1q41 encoding an innate immune receptor for bacterial flagellin; signals via MyD88 to NF-κB; the TLR5^392STOP variant affects Legionnaires' disease, lupus, and Crohn's disease risk.
TLR6
TLR6 (Toll-like receptor 6), gene at 4p14, is an innate immune receptor that signals only in heterodimers, mainly TLR2-TLR6, recognizing diacylated lipopeptides such as Pam2CSK4 and lipoteichoic acid via a phenylalanine-plugged lipid channel.
TLR7
TLR7 (toll-like receptor 7), also called IMD74 or SLEB17, is an X-linked endosomal innate immune receptor sensing single-stranded RNA via MyD88 signaling; it defends against RNA viruses but drives lupus when overactive.
TLR8
TLR8 (toll-like receptor 8, CD288) is a human X-chromosome gene encoding an endosomal, MyD88-coupled innate immune receptor that senses single-stranded RNA and uridine-rich RNA degradation products; dysregulation links to SLE, rheumatoid arthritis, immunodeficiency, and tuberculosis susceptibility.
TLR9
TLR9 (toll-like receptor 9), also Tlr9, is an endosomal innate-immune receptor recognizing unmethylated CpG DNA; expressed in B cells and plasmacytoid dendritic cells, targeted by CpG ODN agonists and hydroxychloroquine-like antagonists.
TLS 1.3
TLS 1.3 is the version of the Transport Layer Security protocol published as RFC 8446 in August 2018, adding forward secrecy, encrypted handshakes, and a faster 0-RTT mode.
Tlumach Raion
Tlumach Raion (Тлумацький район), a district of Ivano-Frankivsk Oblast, Ukraine, centered on Tlumach; created 1939, restored 1965, abolished 2020 into Ivano-Frankivsk Raion; 683.5 km², 45,700 people.
Tlv Partners
TLV Partners is a Tel Aviv venture capital firm founded by Rona Segev and Eitan Bek in 2015, investing in seed and early-stage Israeli technology startups.
TM
TM is a two-letter abbreviation with meanings across many fields: the trademark symbol ™, the element thulium, DNA melting temperature, Turkmenistan's country code, and the Turing machine.
TM Forum
TM Forum is a global non-profit alliance of telecommunications and technology companies, founded in 1988, that develops standards, frameworks, and best practices for communications service providers.
TM6SF2
TM6SF2 (transmembrane 6 superfamily member 2) is a chromosome 19 gene encoding an ER protein needed for VLDL lipidation; its E167K variant lowers blood lipids and heart risk but raises fatty liver risk.
Tmall (天猫)
Tmall (天猫, "Sky Cat"), formerly Taobao Mall, is Alibaba's Chinese business-to-consumer retail platform where brands sell through flagship stores; launched in 2008, it pioneered the 11.11 shopping festival.
TMBThanachart Bank
TMBThanachart Bank (ttb) is a Thai commercial bank formed by the December 2019 merger of TMB Bank and Thanachart Bank, and the sixth-largest bank in Thailand.
TMC-1
TMC-1 (Taurus Molecular Cloud-1) is a cold, starless dark cloud in Taurus about 450 light-years from Earth, known for the richest molecular inventory of any astronomical source, 188 detected molecules.
TMCM-MnCl3
TMCM-MnCl3 is a lead-free hybrid organic–inorganic perovskite ferroelectric reported in 2017, known for a piezoelectric coefficient of 185 pC/N comparable to PZT ceramics and solution processing at room temperature.
TME trial (NCT01872702)
TME trial (NCT01872702), or Targeted Chemo-elimination of Malaria, was a University of Oxford cluster-randomised trial (2013-2017) testing dihydroartemisinin-piperaquine mass drug administration in 16 Greater Mekong villages; falciparum prevalence fell 92% by month 3.
TME-HME trial
TME-HME (NCT07482527) is a not-yet-recruiting, single-blinded randomized trial at Cairo University testing thoracic versus hip mobility exercises added to core stabilization in 60 patients aged 40-60 with lumbar spondylosis.
TMEM106B
TMEM106B (transmembrane protein 106B) is a lysosomal membrane protein gene on chromosome 7p21; common variants, especially rs1990622, modify risk of FTLD-TDP, LATE, and brain aging, and its C-terminal domain forms amyloid fibrils in neurodegeneration.
TMEM165-CDG
TMEM165-CDG (CDG type IIk, OMIM 614727) is a rare autosomal recessive glycosylation disorder caused by TMEM165 mutations, marked by skeletal dysplasia, psychomotor delay, and treatable in part with oral galactose.
TMEM199-CDG
TMEM199-CDG (CDG-IIp, CDG2P, OMIM 616829) is a rare autosomal recessive congenital disorder of glycosylation caused by TMEM199/VMA12 variants, causing mild non-progressive liver disease, hypercholesterolemia, low ceruloplasmin, and type 2 transferrin patterns mimicking Wilson disease.
TMEM222/RTE1
TMEM222/RTE1 (IPR008496, DUF778) is a conserved multi-pass membrane protein family in plants, animals, and protists; Arabidopsis RTE1 regulates the ETR1 ethylene receptor, human TMEM222 variants cause neurodevelopmental disorder.
TMG Studios
TMG Studios, also known as Tiny Meat Gang Studios, is an American comedy podcast network and production company founded by comedian Noel Miller, producing shows including The TMG Show.
TMGS trial
TMGS (NCT01655641) was a suspended randomized trial at Tribhuvan University Teaching Hospital, Nepal, testing perioperative tranexamic acid (1 g preoperative, then 10 mg/kg 8-hourly for 5 days) for reducing transfusion in 118 patients undergoing major gastrointestinal surgery.
TMK Wanaume
TMK Wanaume, also called Wanaume Family, is a Tanzanian hip-hop and bongo flava collective from Temeke, Dar es Salaam, founded in 2002 and led by rapper Juma Nature.
TMNT (film)
TMNT is a 2007 American computer-animated superhero film written and directed by Kevin Munroe, the fourth theatrical Teenage Mutant Ninja Turtles movie and the first made entirely in CGI.
TMON
TMON (티몬), founded in 2010 as Ticket Monster, is a South Korean e-commerce platform that was Korea's first social commerce service before a 2024 payment crisis forced it into rehabilitation.
TMPO
TMPO (thymopoietin, LAP2, LEMD4) is a human gene at 12q23.1 encoding LEM-domain nuclear protein isoforms alpha (75 kDa), beta (51 kDa), and gamma (39 kDa) by alternative splicing; linked to dilated cardiomyopathy and cancer.