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TNFRSF14
TNFRSF14, best known as HVEM, is a human gene encoding a cell-surface immune receptor that switches between activating and inhibitory signaling and mediates herpes simplex virus entry.
TNFRSF18
TNFRSF18 (GITR, AITR, CD357) is a human TNF receptor superfamily gene on chromosome 1p36.33 encoding a co-stimulatory receptor highly expressed on regulatory T cells and inducible on effector T cells; its agonist antibodies show limited cancer immunotherapy efficacy.
TNFRSF1A
TNFRSF1A (TNFR1, CD120a, p55) is a human gene at 12p13.31 encoding the TNF-α death-domain receptor. Pathogenic variants cause TRAPS, an autosomal dominant periodic fever syndrome treated with IL-1 inhibitors.
TNFRSF1B
TNFRSF1B (TNFR2, CD120b, p75) is the human gene at 1p36.22 encoding tumor necrosis factor receptor 2, a 461-amino-acid TNF-alpha receptor lacking a death domain, linked to Treg expansion, immunoregulation, and TNFR2-targeted biologics.
TNFRSF4
TNFRSF4 (OX40, CD134, ACT35) is a human chromosome 1p36.33 gene encoding a 277-amino-acid TNF receptor superfamily costimulatory receptor for OX40L on activated T cells, an HHV-6B receptor linked to combined immunodeficiency IMD16.
TNFRSF6B
TNFRSF6B (DcR3, TR6, M68), gene at 20q13.33, encodes a secreted 300-aa soluble decoy receptor of the TNFR superfamily that neutralizes FasL, LIGHT, and TL1A; overexpressed in gastrointestinal tumors.
TNFSF11
TNFSF11 (RANKL, TRANCE, ODF, OPGL, CD254) is a human protein-coding gene at 13q14.11 encoding a TNF-family cytokine that drives osteoclast differentiation via RANK, is decoyed by OPG, and causes recessive osteopetrosis 2 when mutated.
TNFSF12
TNFSF12 (TWEAK, APO3L) is a human gene on chromosome 17p13.1 encoding a TNF superfamily cytokine that binds the Fn14 receptor, activates NF-κB and MAPK signaling, and is targeted by the antibody BIIB023 in autoimmune disease trials.
TNFSF13B
TNFSF13B (BAFF, BLyS, CD257) is a human chromosome 13q33.3 gene encoding a TNF-family cytokine that binds BAFF-R, TACI, and BCMA to drive B cell survival; excess BAFF causes autoimmunity and belimumab blocks it in SLE.
TNFSF14
TNFSF14 (CD258, LIGHT) is a 29 kD TNF superfamily cytokine from activated T cells, NK cells, and dendritic cells that signals via HVEM and LTβR, driving T cell costimulation, fibrosis, and antitumor immunity.
TNFSF15
TNFSF15 is a human gene on chromosome 9q32 that encodes TL1A, a TNF-family cytokine that stimulates immune cells and is a major drug target in inflammatory bowel disease.
TNFSF4
TNFSF4, best known as OX40 ligand (OX40L) or CD252, is a human cytokine gene of the TNF family that costimulates activated T cells through the OX40 receptor.
TNIP1
TNIP1 (ABIN-1, NAF1, VAN) is a human chromosome 5q33.1 gene encoding a ubiquitin-binding adapter that, with A20, inhibits NF-κB inflammatory signaling; variants associate with lupus, psoriasis, and psoriatic arthritis.
TNK
TNK is a Turkish alternative rock and pop group founded in 2001 in Ankara, best known for "Aşkı Harcamanın 80 Yolu" and "Yine Yazı Bekleriz".
TNKS
TNKS (tankyrase 1, PARP5A/ARTD5, gene ID 8658, 8p23.1) encodes a PARP-family enzyme that PARylates TRF1, AXIN, and NuMA to regulate telomeres, Wnt/β-catenin signaling, and mitosis; a tankyrase inhibitor drug target.
TNM staging system
The TNM staging system, also called the TNM classification, classifies cancer by tumor size, lymph node involvement, and metastasis, and is the world's most widely used staging system.
TNNI3
TNNI3 (troponin I3, cardiac type; cTnI) is a human gene on chromosome 19q13.42 encoding cardiac troponin I, the inhibitory troponin subunit of heart muscle. Mutations cause hypertrophic (type 7), restrictive, and dilated cardiomyopathy; about 5% of HCM cases.
TNNT2
TNNT2 (troponin T2, cardiac type; cTnT) is a gene on chromosome 1q32.1 encoding cardiac troponin T, the tropomyosin-binding calcium regulator of heart contraction; mutations cause hypertrophic, dilated, and restrictive cardiomyopathy.
TNP03-related limb-girdle muscular dystrophy D2
TNP03-related limb-girdle muscular dystrophy D2 (LGMDD2, formerly LGMD1F, OMIM 608423) is an ultrarare autosomal dominant dystrophy from TNPO3 mutations, causing proximal girdle weakness, dysphagia, and arachnodactyly without cardiac involvement.
TNPO1
TNPO1 (transportin 1, karyopherin β2, Kapβ2), human gene at 5q13.2 encoding a nuclear import receptor that carries PY-NLS cargo such as hnRNP A1, FUS, and BAP1 into the nucleus; linked to ALS and cancers.
TNRC6A
TNRC6A (GW182), human gene on 16p11.2 encoding a 1,962-aa miRISC scaffold protein; N-terminal GW repeats bind AGO1-4, C-terminal silencing domain represses mRNAs independently of Argonaute; linked to FAME6.
TNT
TNT, or 2,4,6-trinitrotoluene (C7H5N3O6), is a yellow, odorless crystalline explosive made by nitrating toluene in three stages, used in military shells, bombs, grenades, and underwater and industrial blasting.
TNT (American TV network)
TNT (Turner Network Television) is an American basic cable network launched October 3, 1988 by Ted Turner from Atlanta on the MGM film library, opening with Gone with the Wind; now a Warner Bros. Discovery drama and sports channel.
TNT equivalent
TNT equivalent is a conventional energy unit expressing explosive yields as the mass of TNT releasing the same energy, with one gram defined as 4,184 joules.
TNT Sports (United Kingdom)
TNT Sports (UK), formerly BT Sport, is a British pay-TV sports broadcaster run as a 50:50 BT Group and Warner Bros. Discovery joint venture since 18 July 2023, streaming on HBO Max since March 2026, holding 52 Premier League matches and cycling's Grand Tours but losing UEFA rights from 2027.
TNT trial (NCT00327691)
TNT (Treating to New Targets, NCT00327691) was a Pfizer-funded randomized trial of atorvastatin 80 mg versus 10 mg daily in 10,001 stable coronary disease patients, showing 22% fewer major cardiovascular events with intensive LDL lowering.
TNT trial (NCT06496321)
TNT (NCT06496321), Morbidity of Conventional and No-touch Saphenectomy in CABG: Uruguayan randomized non-inferiority trial at Instituto Nacional de Cirugia Cardiaca, Montevideo, comparing leg wound morbidity of no-touch versus conventional saphenous vein harvesting in 52 patients.
Tnvp Harvest Power
TNVP Harvest Power is a pair of Delaware venture capital funds managed by True North Venture Partners of Phoenix, Arizona, which raised $105.7 million in 2012 and 2014.
To a Land Unknown
To a Land Unknown (2024) is a drama-thriller directed by Mahdi Fleifel, following Palestinian cousins stranded in Athens who attempt to secure forged passports to Germany.
To a Lost One
"To a Lost One" is a poem by the Filipino poet Angela Manalang Gloria, an elegiac work in English often cited as an example of sentimentality in early Philippine poetry.