All articles starting with P
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Profile-guided optimization
Profile-guided optimization (PGO), also known as feedback-directed optimization (FDO), is a compiler technique that uses data about a program's actual execution to guide optimization decisions like inlining and code layout.
Profiler (TV series)
Profiler is an American NBC crime drama (1996–2000, four seasons) created by Cynthia Saunders, starring Ally Walker as FBI profiler Dr. Sam Waters hunting serial killer Jack of All Trades, later led by Jamie Luner as Rachel Burke.
Profiles in Courage
Profiles in Courage is John F. Kennedy's 1956 Pulitzer-winning book of biographical sketches of eight politically courageous U.S. senators, largely researched and drafted by aide Ted Sorensen.
Profilin
Profilin: a small (12-15 kDa), ubiquitous actin-monomer-binding protein that accelerates nucleotide exchange and delivers ATP-actin to formins and Ena/VASP; humans have four isoforms (PFN1-PFN4) with distinct tissue roles and disease links including ALS.
Profilometry
Profilometry, or surface profilometry, is the quantitative measurement of surface topography, in which an instrument traces or images a surface and records height as a function of position.
PROFINET
PROFINET, short for PROcess FIeld NETwork, is an Industrial Ethernet standard for real-time communication between controllers and devices in automation, maintained by PROFIBUS & PROFINET International.
Profinite group
A profinite group is a topological group that is an inverse limit of finite groups, or equivalently a compact, totally disconnected group; Galois groups of infinite extensions are examples.
Profinite integer
A profinite integer is an element of the ring of profinite integers, the inverse limit of the residue rings of the integers modulo every positive integer.
Profit (economics)
Profit in economics is the revenue left after all costs, including the opportunity cost of the firm's own resources, so it can be zero even when accounting profit is positive.
Profit centre
A profit center is a business segment whose manager is responsible for both its revenues and its costs, and therefore its profit, but typically not major capital investment decisions.
Profit margin
Profit margin, also called net margin, is the percentage of sales revenue a company keeps as profit after deducting costs, reported at gross, operating, and net levels.
Profit maximization
Profit maximization is the assumption in neoclassical microeconomics that a firm chooses output, price, or inputs to make total revenue minus total cost as large as possible.
Profit sharing
Profit sharing is a form of remuneration in which employees receive a share of a firm's profits, fixed in advance by agreement rather than left to discretion.
Profitability index
The profitability index (PI) is a capital budgeting ratio dividing a project's present value of future cash flows by its initial investment, with projects accepted when it exceeds 1.
Profiterole
Profiterole: a small filled pastry of puffed choux pastry (pâte à choux), classically filled with Chantilly cream or vanilla ice cream and coated in hot chocolate sauce; 16th-century French word from profit, related to cream puffs, éclairs, and croquembouche.
Profitis Ilias (HP Taygetos)
Profitis Ilias (Προφήτης Ηλίας), about 2,404–2,407 m, is the highest peak of Mount Taygetos and of the Peloponnese, Greece, climbed via the Varvara refuge (1,550 m) on the European E4 trail near Sparta.
Profitwell
ProfitWell, originally named Price Intelligently, was a Boston-based subscription metrics and pricing software company founded by Patrick Campbell in 2012 and acquired by Paddle in 2022.
Profound Lore Records
Profound Lore Records is a Canadian independent record label specializing in extreme metal, founded by Chris Bruni in May 2004 and based in the Kitchener, Ontario area.
ProfoundBio (普方生物)
ProfoundBio (普方生物) was a clinical-stage biotechnology company founded in Seattle in 2018 by three former Seagen scientists to develop antibody-drug conjugates for cancer; Genmab acquired it in 2024.
Profoxydim
Profoxydim (BAS 625H, Aura) is a cyclohexanedione ACCase-inhibiting, post-emergence herbicide for grass weeds, mainly Echinochloa, in rice; EU-approved 2011-2021, then banned with Italian emergency derogations.
Profumo affair
The Profumo affair, a 1963 British political scandal: War Secretary John Profumo lied to the Commons about his affair with Christine Keeler, who also saw Soviet naval attaché Yevgeny Ivanov; he resigned, the Denning Report found no security risk, and Macmillan's government fell.
Profundamente
Profundamente is a free-verse poem by the Brazilian modernist poet Manuel Bandeira, first published in his 1930 collection Libertinagem and later included in Estrela da Vida Inteira.
ProGanOS trial
ProGanOS (NCT06378268) is a non-inferiority randomized trial at My Duc Hospital, Ho Chi Minh City, comparing dydrogesterone-based PPOS with cetrorelix GnRH antagonist ovarian stimulation in 626 IVF women, primary outcome ongoing pregnancy.
Progenitor cell
Progenitor cell: a lineage-committed descendant of a stem cell that differentiates into specific mature cell types but lacks durable self-renewal; central to hematopoietic, endothelial, and iPSC-derived cell therapies.
Progenity, Inc.
Progenity, Inc., incorporated in 2012 as Ascendant MDx, Inc., was a San Diego biotechnology company offering prenatal genetic tests, later renamed Biora Therapeutics in 2022.
Progeny testing
Progeny testing is a breeding method that evaluates a parent animal's genetic merit by measuring the performance of its offspring, guiding which parents are selected for the next generation.
Progeria
Progeria (Hutchinson-Gilford progeria syndrome, HGPS) is a rare autosomal dominant premature-aging disorder caused by LMNA mutations producing progerin; about 1 in 4 million newborns, treated with lonafarnib (Zokinvy).
Progeria-short stature-pigmented nevi syndrome
Progeria-short stature-pigmented nevi syndrome, also called Mulvihill-Smith syndrome, is an extremely rare genetic disorder marked by premature aging, short stature, multiple pigmented moles, microcephaly, hearing loss, and immunodeficiency.
Progeroid features-hepatocellular carcinoma predisposition syndrome
Progeroid features-hepatocellular carcinoma predisposition syndrome, or Ruijs-Aalfs syndrome (RJALS, OMIM 616200), is an ultra-rare autosomal recessive SPRTN-related disorder combining early-onset liver cancer, genomic instability, and premature aging features.
Progesterone
Progesterone (P4) is a 21-carbon steroid hormone made in the corpus luteum from pregnenolone; isolated by Corner and Allen in 1929 and named in 1935, it prepares the endometrium, maintains pregnancy, and precedes aldosterone, cortisol, estrogen, and testosterone synthesis.