400 articles
SUP-T1
SUP-T1 (SupT1, Stanford University Pediatric T-cell line 1, CVCL_1714, ATCC CRL-1942) is a human CD4+ T-lymphoblastic lymphoma cell line from an 8-year-old boy, widely used for HIV-1 research and T-ALL studies.
Suspension culture
Suspension culture is a cell culture method in which cells grow free-floating in agitated liquid medium rather than attached to a surface, widely used for producing large volumes of cells.
SW1116
SW1116 (SW-1116, SW 1116), human colon adenocarcinoma cell line CVCL_0544 established in 1976 from a 73-year-old male; microsatellite-stable, APC/KRAS/TP53-mutant, epithelial, CEA-producing colorectal cancer research model.
SW13
SW13 (SW-13, Scott and White No. 13) is a human cancer cell line isolated in 1971 from the adrenal cortex of a 55-year-old woman, long used with NCI-H295R as an adrenocortical carcinoma model despite non-steroidogenic, debated small cell carcinoma origin.
SW1990
SW1990 is a human pancreatic adenocarcinoma cell line established in 1978 from a spleen metastasis, known as a standard model of pancreatic ductal adenocarcinoma and for its gemcitabine resistance.
SW48
SW48 (SW-48, CVCL_1724) is a human colorectal adenocarcinoma cell line from the transverse colon, MSI-high, near-diploid, KRAS/NRAS/BRAF/PIK3CA wild type, widely used in EGFR, KRAS isogenic, and pharmacogenomic studies.
SW480
SW480 (SW-480, CVCL_0546) is a human colon adenocarcinoma cell line established in 1976 from a male donor's primary tumor, KRAS G12V, APC-null, TP53 R273H/P309S, MSS, paired with metastatic line SW620.
SW620
SW620 (SW-620, CVCL_0547) is a human colorectal adenocarcinoma cell line from a lymph node metastasis of a 51-year-old male, sister line to SW480; MSS, CMS4, KRAS G12V, APC and TP53 mutant, used to model metastatic colorectal cancer.
SW948
SW948 (SW-948, SW 948; ATCC CCL-237, DSMZ ACC 326) is a human colon adenocarcinoma cell line from an 81-year-old woman, Dukes' C grade III, MSS, KRAS Q61L-mutant, established by Leibovitz.
SWEIG007
SWEIG007 (Swei, CVCL_E838) is an EBV-transformed human B-lymphoblastoid cell line from a male donor, a homozygous HLA reference line of the 10th International Histocompatibility Workshop (IHW 9037) typed DRB1*11:01, distributed by ECACC as 88052037.
T-47D
T-47D (T47D) is a human breast carcinoma cell line, DSMZ ACC 739 / ATCC HTB-133, established in 1974 from a pleural effusion of a 54-year-old woman; ER/PR-positive, HER2-expressing luminal model with tamoxifen-resistant Tam1/Tam2 derivatives.
T24
T24 (T-24, CVCL_0554, ATCC HTB-4) is a human bladder carcinoma cell line established in Sweden from an 82-year-old woman, reported 1973; HRAS G12V, TP53-mutant, invasive poorly differentiated urothelial cancer model.
T98G
T98G (T-98G), a human glioblastoma multiforme cell line from a 61-year-old male, hyperpentaploid, temozolomide-resistant, IDH wild-type; ATCC CRL-1690, Cellosaurus CVCL_0556.
TE-1
TE-1 (TE1, CVCL_1759) is a human esophageal squamous cell carcinoma cell line established in 1979 from a 58-year-old Japanese male, with 60-hour doubling time, TP53 p.Val272Met, MSS status, and wide use in drug-resistance and immunotherapy research.
TE-10
TE-10 (CVCL_1760, TE10) is a human esophageal squamous cell carcinoma cell line from a 58-year-old Japanese male, highly differentiated, TP53-mutant, MSS, RPMI-1640 cultured, distributed by RIKEN (RCB2099) and TKG.
TE-11
TE-11 (CVCL_1761, RCB2100) is a human esophageal squamous cell carcinoma cell line from a 58-year-old Japanese man, moderately differentiated, TP53 p.Arg110Leu, MSS, established by Nishihira's TE series.
TE-2
TE-2 (TE2, CVCL_4455) is a human esophageal squamous cell carcinoma cell line established in 1979, doubling every 72 hours, now flagged as contaminated because it is genotypically identical to TE-3, TE-7, TE-12, and TE-13 (ICLAC-00275).
THP-1
THP-1 (Tohoku Hospital Pediatrics-1), human monocytic leukemia cell line from a 1-year-old boy, established 1978, described 1980; suspension monocyte-like cells with KMT2A-MLLT3 fusion, PMA-differentiable into macrophages; distinct from B-THP-1, a misidentified Raji derivative.
TPC-1
TPC-1 (TPC1, CVCL_6298) is a human papillary thyroid carcinoma cell line from an adult Japanese female, carrying the CCDC6-RET (RET/PTC1) fusion, BRAF wild type; several BHP lines and FB-2 are STR-identical duplicates.
Two-dimensional cell culture
Two-dimensional cell culture is the bench method of growing anchorage-dependent cells as a flat monolayer on treated polystyrene, the default for growing animal and human cells for over a century.
U-118MG
U-118MG (U-118 MG, U118) is a human glioblastoma cell line, Cellosaurus CVCL_0633, ATCC HTB-15, established in 1968; shown to be a contaminated U-138MG derivative with homozygous PTEN and TP53 mutations, used widely in glioma drug screening.
U-251MG
U-251MG (U251, CVCL_0021) is a human glioblastoma/astrocytoma cell line from a 75-year-old male, established in 1960s Uppsala; TP53/PTEN mutant, NCI-60 member, known for U-373 cross-contamination and subclone genetic drift.
U-343MG
U-343MG (CVCL_S471), also written U343MG or U-343, is a human glioblastoma cell line from a male donor's temporal lobe, GFAP-negative and mesenchymal, part of the U-343 same-tumor panel with U-343MGa.
U-373MG Uppsala
U-373MG Uppsala, also written U-373 MG (Uppsala), is the original human glioblastoma astrocytoma cell line, established in 1973 at the University of Uppsala and distinguished from the widely distributed stock that is actually U-251 MG.
U-87MG ATCC
U-87MG ATCC (HTB-14, CVCL_0022), also called U87MG or U87, is a widely used human glioblastoma cell line of male CNS origin that is misidentified: it is not the original 1968 Uppsala U87MG line from a 44-year-old woman.
U-937
U-937 (U937) is a human pro-monocytic leukemia cell line established in 1974 from a 37-year-old man's histiocytic lymphoma pleural effusion; widely used to study monocyte-macrophage differentiation, apoptosis, and inflammation.
U266B1
U266B1 (U266, U-266; CVCL_0566, ATCC TIB-196) is a human IgE lambda-secreting B lymphocyte myeloma cell line established in 1970 from a 53-year-old male patient, used widely in multiple myeloma and immunology research.
U2OS
U2OS (U-2 OS), human osteosarcoma cell line from a 15-year-old girl's tibia, established 1964 by Ponten and Saksela; first human osteosarcoma line, p53 wild-type, epithelial-like morphology, standard model for DNA damage and imaging research.
UM-SCC-1
UM-SCC-1, also written UMSCC-1 or SCC-1, is a human head and neck squamous cell carcinoma cell line established at the University of Michigan in 1981 from a recurrent floor-of-mouth tumor.
UM-UC-3
UM-UC-3 (UMUC3, CVCL_1783, ATCC CRL-1749) is a human bladder carcinoma cell line from a male patient, KRAS G12C and TP53 mutant, CDKN2A/PTEN deleted, widely used in orthotopic bladder cancer models.