400 articles
PC-6
PC-6 (CVCL_C002, also PC 6, PC6) is a human small cell lung carcinoma cell line established by Immuno-Biological Laboratories, Tokyo, from a Japanese donor, used in chemotherapy and drug-resistance research with nine drug-resistant sublines.
PC-9
PC-9 (PC9, CVCL_B260) is a human lung adenocarcinoma cell line from a 45-year-old male, carrying the EGFR exon 19 delE746-A750 deletion and homozygous TP53 R248Q; a standard EGFR-TKI sensitivity and drug-resistance model, formerly confused with PC-14.
PC12
PC12 (PC-12) rat adrenal pheochromocytoma cell line established by Greene and Tischler in 1976; synthesizes dopamine and norepinephrine and differentiates into sympathetic-neuron-like cells in response to NGF; standard neuroscience model, ATCC CRL-1721.
Pfeiffer
Pfeiffer (ATCC CRL-2632, CVCL_3326) is a human B lymphocyte cell line established in 1992 from pleural effusion of an adult male with diffuse large B-cell lymphoma; EBV-negative, CD10/CD19/CD20/CD38-positive, IgG kappa, t(14;18), used to study non-Hodgkin lymphoma.
PK-1
PK-1 (PK1, CVCL_4717) is a human pancreatic ductal adenocarcinoma cell line established in 1984 from a liver metastasis; male donor, Japanese origin, KRAS G12D, TP53 mutant, held as RCB1972/TKG 0239. Distinct from KP-1N and LLC-PK1.
PK-15
PK-15 (CVCL_2160, ATCC CCL-33) is a spontaneously immortalized porcine kidney epithelial cell line cloned in 1957 from PK-2a, used widely for swine virus research, vaccine production, and PERV-inactivation studies; it is aneuploid and carries PCV1 and endogenous C-type retrovirus.
PL-21
PL-21 (PL21, CVCL_2161) is a human acute promyelocytic leukemia cell line established in 1981 from peripheral blood, peroxidase-positive, lacking t(15;17), with FLT3-ITD, KRAS and TP53 mutations.
Rael
Rael (Rael-BL, RAEL; CVCL_7208) is a human EBV-positive Burkitt lymphoma B-cell line from a male Kenyan donor, a latency I model expressing only EBNA1, used in EBV methylation and gene regulation studies.
RAW 264.7
RAW 264.7 (TIB-71, CVCL_0493) is an immortalized BALB/c mouse macrophage cell line transformed by Abelson murine leukemia virus, established in 1978, used widely in inflammation, LPS, nitric oxide, and osteoclastogenesis research.
RBL-2H3
RBL-2H3 (rat basophilic leukemia 2H3, CVCL_0591, ATCC CRL-2256) is a Wistar rat basophilic leukemia cell line cloned in 1978; it expresses high-affinity IgE receptors, degranulates and releases histamine on FcεRI aggregation, and is a standard in vitro allergy and secretion model.
RD-ES
RD-ES (RDES, CVCL_2169) is a human Ewing sarcoma cell line established in 1984 from the humerus tumor of a 19-year-old man, carrying a type 2 EWSR1-FLI1 fusion, TP53 p.R273C, and CD99-positive/CD45-negative phenotype.
Rh18
Rh18, also called SJRH-18, is a human rhabdomyosarcoma cell line established at St. Jude Children's Research Hospital from a two-year-old girl's perineal tumor, used widely in pediatric sarcoma research.
Rh28
Rh28 (SJRH-28, CVCL_8752) is a human alveolar rhabdomyosarcoma cell line from a 17-year-old male, PAX3-FOXO1 fusion-positive, near tetraploid, established via xenograft at St. Jude in 1987, notable for spontaneous senescence and use in PPTP drug testing.
Rh30
Rh30 (SJCRH30, RMS13, CVCL_0041) is a human alveolar rhabdomyosarcoma cell line from a bone marrow metastasis, carrying the PAX3-FOXO1 fusion, TP53 mutations, and 12q13-q15 CDK4 amplification; distributed by ATCC and DSMZ.
Rh4
Rh4 (RH4, SJRH-4, CVCL_5916) is a human alveolar rhabdomyosarcoma cell line from a 7-year-old girl's lung metastasis, PAX3-FOXO1 fusion-positive with TP53 mutation, paired with RH41 from the same patient.
Ri-1
Ri-1 (RIVA, RI-1, CVCL_1885, DSMZ ACC 585) is a human ABC-type diffuse large B-cell lymphoma cell line established in 1977 from a 57-year-old woman's peripheral blood, EBV-negative, with TP53 mutation, RB inactivation, and MYC/BCL2 lesions.
RIN-m5F
RIN-m5F (RINm5F, RIN-5F) is a clonal rat pancreatic beta cell line from an X-ray-induced NEDH rat insulinoma, a clone of RIN-m. It secretes insulin and L-dopa-decarboxylase, has low insulin content, poor glucose responsiveness, and is used in insulin gene regulation and beta-cell apoptosis research (ATCC CRL-3660, CVCL_0501).
RK 13
RK 13 (RK13, Glaxo Laboratories Rabbit Kidney 13) is a spontaneously immortalized rabbit kidney epithelial cell line established in 1959, ATCC CCL-37, used as a susceptible host for rubella, vaccinia, herpes, and other viruses.
RL95-2
RL95-2 (CVCL_0505, ATCC CRL-1671) is a human endometrial adenosquamous carcinoma cell line from a 65-year-old woman, MSI-high, ER-positive, used in cancer research and as a receptive-endometrium adhesion model.
RMG-I
RMG-I (RMG1, RMG-1; CVCL_1662) is a human ovarian clear cell adenocarcinoma cell line established in 1988 from ascites of a 34-year-old Japanese woman; aneuploid, CDKN2A-deleted, listed by ICLAC as contaminated by RMG-II.
RPMI-8226
RPMI-8226 (ATCC CCL-155, CVCL_0014) is a human B lymphocyte cell line established in 1966 from a plasmacytoma patient; among the first multiple myeloma lines, it produces free lambda light chains and ranks 48 of 66 for patient tumor similarity.
RT-112
RT-112 (RT112, CVCL_1670) is a human bladder transitional cell carcinoma cell line established in 1973 from a grade G2 tumor in a woman; a low-grade, luminal-type preclinical model with FGFR3-TACC3 fusion, deleted CDKN2A, and heterozygous TP53 mutations.
RT-4
RT-4 (RT4, RT4P; CVCL_0036, ATCC HTB-2) is a human bladder cancer cell line from a recurrent grade I transitional cell carcinoma, used as a well-differentiated, luminal, low-grade urothelial carcinoma model with FGFR3-TACC3 fusion and wild-type p53.
RTG-2
RTG-2 (Rainbow Trout Gonad-2), also written RTG2, is the first permanent fish cell line, established from rainbow trout gonad by Wolf and Quimby in 1962; a fibroblast-like, spontaneously immortalized line (ATCC CCL-55) used in fish virology, ecotoxicology, and genotoxicity testing.
RWPE-1
RWPE-1 (ATCC CRL-11609/CRL-3607, CVCL_3791) is a non-tumorigenic human prostate epithelial cell line from a 54-year-old male donor, immortalized with HPV-18; parent of RWPE-2 and MNU-derived WPE1 lines.
S462
S462 (CVCL_1Y70, "Patient 6 cell line") is a human NF1-associated malignant peripheral nerve sheath tumor cell line from a 19-year-old woman's thigh, carrying germline NF1 6792C>A, NF1 and p53 LOH, and p53 329G>C; a widely used MPNST drug-screening and xenograft model.
SaOS-2
SaOS-2 (Saos-2, Sarcoma OSteogenic-2), ATCC HTB-85, CVCL_0548, is a human osteosarcoma cell line established in 1973 by Fogh from an 11-year-old girl, with osteoblastic features, high alkaline phosphatase, and homozygous TP53 deletion.
SCC-25
SCC-25, also known as SCC25, is a human cancer cell line derived from a 70-year-old man's tongue squamous cell carcinoma, used widely in oral cancer research.
SCC-4
SCC-4 (SCC4, CVCL_1684, ATCC CRL-1624) is a human tongue squamous cell carcinoma cell line from a 55-year-old male, established by Rheinwald and Beckett, TP53-mutant, used widely in oral cancer, drug response, and radioresistance research.
SCC-9
SCC-9 (SCC9, CVCL_1685, ATCC CRL-1629) is a human tongue squamous cell carcinoma cell line from a 25-year-old man, established 1981, cisplatin-resistant, TP53-mutant, and widely used in oral cancer research.