400 articles
Schneider 1
Schneider 1 (S1, CVCL_Z231, RRID:CVCL_Z231) is a spontaneously immortalized Drosophila melanogaster cell line from whole Oregon-R embryos, established by Imogene Schneider in 1972; male, tetraploid, 32-35 hour doubling time, distinct from the S2 and S3 Schneider lines.
Schneider 2
Schneider 2 (S2, SL2, CVCL_Z232) is a Drosophila melanogaster embryonic cell line established by Imogene Schneider (1972 paper; ATCC dates 1969). Hemocyte-like, phagocytic, room-temperature culture without CO2; standard for RNAi screens and recombinant protein expression.
Serial passage
Serial passage is a bench technique that repeatedly transfers cells or microbes into fresh environments, selecting variants adapted to them, which often means loss of virulence.
SGC-7901
SGC-7901 (SGC7901, CVCL_0520) is a human cell line established in China in 1982 as a gastric adenocarcinoma model but shown by STR profiling to be a HeLa derivative, registered as misidentified (ICLAC-00577) yet still widely used.
SH-SY5Y
SH-SY5Y (CVCL_0019, ATCC CRL-2266, ECACC 94030304) is a human neuroblastoma cell line, a thrice-cloned subline of SK-N-SH from a 1970 pediatric bone marrow biopsy, used as a differentiable neuronal model in neuroscience and toxicology research.
SiHa
SiHa (CVCL_0032, ATCC HTB-35) is an HPV16-positive human cervical squamous cell carcinoma cell line established in 1970 from a 55-year-old Japanese patient, widely used in cervical cancer research.
SJNB-10
SJNB-10 (SJ-NB-10, NB10, NB90-9; CVCL_1441) is a human neuroblastoma cancer cell line from a 2-year-old male with an adrenal primary and liver metastasis, characterized by homozygous NF1 deletion, loss of neurofibromin, and retinoic acid resistance.
SJNB-12
SJNB-12 is a human neuroblastoma cell line derived from a bone marrow metastasis in a female infant sampled at 10 months of age, with high BCL-2 expression.
SJSA-1
SJSA-1 (OsA-CL, OSA; ATCC CRL-2098, RRID CVCL_1697) is a human osteosarcoma cell line established in 1982 from a 19-year-old male's femur tumor, distinguished by ~20-fold MDM2 amplification with wild-type TP53.
SK-BR-3
SK-BR-3 (SKBR3), ATCC HTB-30, Cellosaurus CVCL_0033: human breast adenocarcinoma cell line established 1970 from a pleural effusion; HER2-positive, ER/PR-negative standard model for HER2-targeted therapy research.
SK-ES-1
SK-ES-1 (SK-ES-01, CVCL_0627) is a human Ewing sarcoma cell line established in 1971 from an 18-year-old male's bone biopsy at Memorial Sloan Kettering; it carries an EWSR1-FLI1 type 2 fusion and TP53 C176F.
SK-HEP-1
SK-HEP-1 (CVCL_0525, ATCC HTB-52) is a human cancer cell line established in 1971 from ascites of a 52-year-old man with liver adenocarcinoma; long used as a hepatocellular carcinoma model but now shown to be of endothelial origin.
SK-MEL-2
SK-MEL-2 (CVCL_0069, ATCC HTB-68) is a human melanoma cell line from a 60-year-old male, established at Memorial Sloan Kettering; NRAS Q61R-mutant, TP53 G245S, NCI-60 panel member.
SK-MEL-23
SK-MEL-23 (CVCL_6027, SKMEL23) is a highly pigmented human cutaneous melanoma cell line from Memorial Sloan Kettering, established from a metastatic lymph node; PTEN-deleted, NRAS wild type, BRAF fusion, used in pigmentation, drug response, and immunotherapy research.
SK-MEL-5
SK-MEL-5 (CVCL_0527, ATCC HTB-70) is a human melanoma cell line established in 1974 from a metastatic axillary lymph node of a 24-year-old woman, carrying BRAF V600E and a CDKN2A deletion, used in NCI-60 drug screening and immunology research.
SK-MES-1
SK-MES-1 (SK MES 1, CVCL_0630, ATCC HTB-58) is a human lung squamous cell carcinoma cell line established in 1970 from a pleural effusion of a 65-year-old man at Memorial Sloan Kettering by Old and Trempe; epithelial, adherent, TP53-mutant.
SK-N-AS
SK-N-AS (ATCC CRL-2137, Cellosaurus CVCL_1700) is a human neuroblastoma cell line established in 1981 from a bone marrow metastasis in a 6-year-old girl; non-MYCN-amplified, IGF-II-producing, S-type, tumorigenic in nude mice.
SK-N-BE(2)-C
SK-N-BE(2)-C (BE2C, CVCL_0529, ATCC CRL-2268) is a clonal subline of the SK-N-BE(2) human neuroblastoma cell line, MYCN-amplified with a TP53 C135F mutation, I-type phenotype, derived from a 1972 bone marrow metastasis.
SK-N-MC
SK-N-MC (ATCC HTB-10, CVCL_0530) is a human cell line established in 1971 from a supra-orbital metastasis of an Askin tumor; long mislabeled neuroblastoma, it is an Ewing sarcoma line carrying EWS-FLI1.
SK-N-SH
SK-N-SH (CVCL_0531, ATCC HTB-11) is a human neuroblastoma cell line established in 1970 from the bone marrow metastasis of a four-year-old girl at Memorial Sloan Kettering; parent of SH-SY5Y and SH-EP, with ALK F1174L and NRAS Q61K mutations.
SK-OV-3
SK-OV-3 (SKOV3), human ovarian cancer cell line, CVCL_0532, ATCC HTB-77, established 1973 at Memorial Sloan Kettering from ascites of a 64-year-old woman; epithelial, drug-resistant, most cited ovarian cancer line but a poor HGSOC model, likely clear cell origin.
SKM-1
SKM-1 (also SKM1, CVCL_0098, DSMZ ACC 547) is a human acute myeloid leukemia cell line established in 1989 from a 76-year-old Japanese man with AML M5 following myelodysplastic syndrome, doubling in about 48 hours, with TP53 R248Q, TET2, and ASXL1 mutations, used to study MDS-to-AML progression.
SMS-KAN
SMS-KAN (CVCL_7131) is a human neuroblastoma cell line established in 1978 from a pelvic primary tumor of a 36-month-old girl before therapy; its paired post-treatment line SMS-KANR came from the same patient's relapsed bone marrow, making the pair a before/after-chemotherapy model.
SMS-KCNR
SMS-KCNR (KCNR, CVCL_7134) is a human neuroblastoma cell line established in 1979 from bone marrow after chemotherapy, MYCN-amplified with ALK F1174L, paired with SMS-KCNR's pre-treatment counterpart SMS-KCNR's sister line SMS-KCN, and widely used in differentiation and drug-resistance research.
SNB-19
SNB-19 (SNB19, Surgical Neurology Branch-19), human glioblastoma cell line CVCL_0535, NCI-60 panel member; STR profiling shows it is a U-251MG derivative, registered as misidentified ICLAC-00268.
SNU-1
SNU-1 (NCI-SNU-1, CVCL_0099, ATCC CRL-5971) is a human gastric adenocarcinoma cell line established in 1984 at Seoul National University from a primary stomach tumor; near-diploid, MSI-positive, suspension-growing, and widely used in cancer pharmacogenomics.
Sq-1
Sq-1 (CVCL_4900, RRID:CVCL_4900) is a human lung squamous cell carcinoma cancer cell line from a Japanese male, carrying EGFR L858R (in 10% of cells) and a TP53 splice donor mutation, distributed as RCB1905 and TKG 0301.
ST88-14
ST88-14 (CVCL_8916) is a human NF1-associated malignant peripheral nerve sheath tumor cell line from a 24-year-old man's retroperitoneal tumor, neurofibromin-deficient, and the genuine line behind the misidentified T265.
SUM149PT
SUM149PT (CVCL_3422, RRID:CVCL_3422), also called SUM149, is a human triple-negative, BRCA1-mutant inflammatory breast cancer cell line derived from a primary invasive ductal carcinoma, used widely in IBC and TNBC drug research.
SUM159PT
SUM159PT (SUM-159, CVCL_5423) is a human triple-negative, claudin-low breast cancer cell line from an anaplastic pleomorphic carcinoma of a 71-year-old woman, with HRAS G12D, PIK3CA H1047L, TP53 mutations, used for estrogen-independent and invasive breast cancer research.