400 articles
NCI-H650
NCI-H650 (H650, CVCL_1575) is a human lung adenocarcinoma cell line from a male with bronchioalveolar carcinoma, established 1983 by Gazdar and Minna; KRAS Q61L and TP53 K164N homozygous, microsatellite stable, floating spherical growth.
NCI-H660
NCI-H660 (CVCL_1576, ATCC CRL-5813) is a human epithelial neuroendocrine cancer cell line from a cervical lymph node metastasis of prostate small cell carcinoma in a 63-year-old man; AR-negative, TMPRSS2-ERG fusion-positive, suspension-growing model of neuroendocrine prostate cancer.
NCI-H661
NCI-H661 (H661, CVCL_1577, ATCC HTB-183) is a human NSCLC large cell carcinoma cell line derived in 1982 from a 43-year-old male's lymph node metastasis, TP53- and CDKN2A-mutant, EGFR wild-type.
NCI-H69
NCI-H69 (H69, HTB-119, CVCL_1579) is a human small cell lung cancer cell line from a 55-year-old man's pleural effusion, N-myc amplified, RB1/TP53 mutant, parent of drug-resistant variants H69AR and H69/LX4.
NCI-H716
NCI-H716 (H716, ATCC CCL-251) is a human cecal colorectal adenocarcinoma cell line, suspension-growing and hypotriploid, used as the main model of human intestinal L cells for GLP-1 secretion and notable for FGFR2 amplification.
NCI-H747
NCI-H747 (H747, CVCL_1587) is a human colorectal adenocarcinoma cell line from the cecum of a 69-year-old male, derived from a lymph node metastasis, carrying APC, KRAS G13D, and TP53 mutations, available as ATCC CCL-252.
NCI-H748
NCI-H748 (H748, CVCL_1588, ATCC CRL-5841) is a human small cell lung cancer cell line from a 62-year-old African American man's lymph node metastasis, carrying TP53, RB1, and BRCA2 mutations, used in SCLC pharmacogenomic and drug screening studies.
NCI-H774
NCI-H774 (H774, CVCL_1589, ATCC CRL-5842) is a human small cell lung cancer cell line established in 1984 from a 43-year-old male smoker's soft-tissue metastasis; suspension-growing, TP53 R342, MAP2K4-deleted.
NCI-H810
NCI-H810 (H810, CVCL_1590, ATCC CRL-5816) is a human lung large cell/non-small cell lung cancer cell line from a 51-year-old Black male, TP53 and DDR2 mutant, NMB/GRP non-synthesizing, used in cancer research.
NCI-H82
NCI-H82 (H82, CVCL_1591) is a human small cell lung carcinoma cell line derived in 1978 by Gazdar from a male patient's pleural effusion; a variant SCLC model with ~25-fold c-myc amplification, suspension growth, and TP53 splicing mutation.
NCI-H820
NCI-H820 (H820, CVCL_1592, ATCC HTB-181) is a human lung papillary adenocarcinoma cell line derived in 1984 by Gazdar and Oie from a supraclavicular lymph node metastasis, notable for TP53 Thr284Pro and dual EGFR activating/T790M mutations.
NCI-H841
NCI-H841 (H841, CVCL_1595, ATCC CRL-5845) is a human lung cancer cell line established in 1984, originally variant small cell lung cancer, reclassified in 2024 as a thoracic SMARCA4-deficient undifferentiated tumor with homozygous SMARCA4 and TP53 mutations.
NCI-H920
NCI-H920 (H920, CVCL_1599, ATCC CRL-5850) is a human lung adenocarcinoma cell line established in December 1984 from a 43-year-old male 75 pack-year smoker; NSCLC stage 4 model with TP53 c.560-1G>T, floating-aggregate growth, and extensive omics data.
NCI-N231
NCI-N231 (N231, NCI-H231, CVCL_A788) is a human small cell lung cancer cell line established in 1980 from a mouse xenograft, female, carrying a TP53 p.Glu298Ter nonsense mutation, used in SCLC drug-sensitivity research.
NCI-N87
NCI-N87, also written N87, is a human gastric cancer cell line created at the National Cancer Institute in 1976 from a liver metastasis of a stomach carcinoma.
NCTC clone 929
NCTC clone 929 (L929, L cell) is the first cloned strain of Earle's mouse strain L fibroblast line, cloned in 1948; a spontaneously immortalized C3H/An mouse fibroblast used as the standard ISO 10993-5 cytotoxicity test cell.
Neuro-2a
Neuro-2a, also written N2a or NB2a, is a mouse neuroblastoma cell line established in 1969 and used widely as a neuronal model in neuroscience and cancer research.
NIH 3T3
NIH 3T3 (NIH/3T3, NIH3T3) is a spontaneously immortalized mouse embryonic fibroblast cell line from an NIH Swiss mouse, contact-inhibited, doubling in about 20 hours, and a standard recipient for DNA transfection and ras oncogene transformation assays.
NK-92
NK-92 (Neukoplast, aNK) is a human natural killer cell line established in 1992 from a lymphoma patient; the only NK cell line in clinical trials, IL-2 dependent, CD16-negative, KIR-deficient, irradiated before infusion.
OE19
OE19 (OE-19, JROECL19, CVCL_1622) is a human esophageal adenocarcinoma cell line established in 1993 from a 72-year-old man, HER2/ERBB2-amplified, lapatinib-sensitive, microsatellite stable, and distributed by ECACC and DSMZ.
Onda 11
Onda 11 (Onda-11, no.11, CVCL_3076) is a human glioblastoma cell line from the right parietal lobe of a 64-year-old Japanese woman, GFAP-positive, PTEN and TP53 mutant, with the strongest ADD3 dependency among DepMap GBM lines.
OS-RC-2
OS-RC-2 (OSRC2, RC-2, CVCL_1626) is a human clear cell renal cell carcinoma cell line established in 1985 from a 52-year-old Japanese male; VHL-null, 3p-deleted, ccB subtype, sorafenib-resistant, used in RCC drug-resistance and metastasis research.
OVCAR-3
OVCAR-3 (NIH:OVCAR-3, ATCC HTB-161, CVCL_0465) is a human high-grade serous ovarian adenocarcinoma cell line established in 1982 from malignant ascites of a 60-year-old woman; cisplatin-resistant, hormone-receptor positive, NCI-60 member.
OVCAR-5
OVCAR-5 (NIH:OVCAR-5, CVCL_1628) is a human cancer cell line from the ascites of a 67-year-old untreated patient, registered as high-grade ovarian serous adenocarcinoma but suspected of upper gastrointestinal origin; NCI-60 member with homozygous KRAS Gly12Val.
OVCAR-8
OVCAR-8 (NIH:OVCAR-8, CVCL_1629) is a human ovarian cancer cell line from a 64-year-old donor, a member of the NCI-60 panel, TP53-mutant, hyperdiploid, and the only HGSOC line tested that reliably forms ascites in nude mice.
Panc 03.27
Panc 03.27, also written Panc 3.27 or PL11, is a human pancreatic adenocarcinoma cell line isolated in 1995 and distributed by ATCC as CRL-2549 for cancer research.
Panc 04.03
Panc 04.03 (CVCL_1636, ATCC CRL-2555) is a human pancreatic ductal adenocarcinoma cell line from a 70-year-old male, derived at Johns Hopkins, carrying KRAS G12D and TP53 G245S mutations, used in migration, drug, and radiotherapy studies.
PANC-1
PANC-1 (Panc-1, CVCL_0480, ATCC CRL-1469) is a human pancreatic ductal adenocarcinoma cell line from a 56-year-old male, reported 1975, carrying KRAS G12D, TP53 R273H, and CDKN2A deletion.
PC-10
PC-10 (PC10, CVCL_7088) is a human lung squamous cell carcinoma cell line from a Japanese female, distributed by IBL Tokyo, carrying TP53 p.Gly245Cys, with cisplatin-resistant sublines PC10-B3 and PC10-E5.
PC-13
PC-13 (CVCL_B259, RRID:CVCL_B259) is a human lung large cell carcinoma cell line from Immuno-Biological Laboratories, Tokyo, from a Japanese male donor, carrying EGFR L858R (in 10% of cells) and TP53 Gly334Val mutations; distinct from the murine PC13 embryonal carcinoma line.