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Desbuquois syndrome
Desbuquois syndrome (DBQD, Desbuquois dysplasia) is a rare autosomal recessive osteochondrodysplasia with severe micromelic dwarfism, joint laxity with multiple dislocations, advanced carpotarsal ossification; caused by CANT1 (type 1, Kim variant) or XYLT1 (type 2) mutations.
Descemet membrane endothelial keratoplasty
Descemet membrane endothelial keratoplasty (DMEK) is a corneal transplant operation replacing the endothelium and Descemet membrane with a thin donor graft, used mainly for Fuchs dystrophy and bullous keratopathy.
Descemet stripping endothelial keratoplasty
Descemet stripping endothelial keratoplasty (DSEK) is a partial-thickness corneal transplant for endothelial disease such as Fuchs dystrophy, replacing the endothelium and Descemet membrane through a small, sutureless incision.
Desensitization (psychology)
Desensitization (systematic desensitization) is Joseph Wolpe's behavior therapy for phobias and anxiety, pairing graded exposure to a feared hierarchy with relaxation via reciprocal inhibition; now largely subsumed under exposure therapy.
Deserpidine
Deserpidine, a Rauwolfia alkaloid antihypertensive related to reserpine, ATC C02AA05/C02LA03, formula C32H38N2O8, first approved 1957; brands Harmonyl, Oreticyl, Enduronyl; depletes catecholamines.
Desflurane
Desflurane: highly fluorinated volatile inhalational anesthetic synthesized by Terrell (compound 653, 1959–1966), introduced 1992; low blood solubility, high vapor pressure needing heated vaporizers, airway irritant, and GWP100 of 2540, now being eliminated worldwide.
Desiderosmia
Desiderosmia is the excessive craving to smell specific odours without wanting to ingest them, associated with iron deficiency anaemia; term coined by Hansen et al. 2017, distinct from pica, resolves with iron replacement.
Desidustat
Desidustat (Oxemia) is an oral HIF prolyl hydroxylase inhibitor for anemia in chronic kidney disease, developed by Zydus Lifesciences and first approved in India in 2022.
Design Interactive
Design Interactive is an Orlando, Florida human-systems engineering firm founded in 1998 by Kay M. Stanney, building AR/VR training systems for military, medical, and aerospace customers.
Designer drug
A designer drug is a synthetic psychoactive substance made by slightly modifying a controlled drug so it mimics the original's effects while evading existing legal controls.
DESIR study
DESIR (DEvenir des Spondylarthropathies Indifférenciées Récentes) is a French inception cohort of 708 patients with recent-onset axial spondyloarthritis, recruited 2007-2010, used to validate ASAS criteria and track 10-year outcomes.
Desirability of outcome ranking
Desirability of outcome ranking (DOOR) is a patient-centric clinical trial endpoint that ranks each patient's overall outcome, combining benefits and harms, and compares treatments by the probability of a more desirable outcome.
Desirudin
Desirudin (Revasc, Iprivask) is a recombinant 65-amino-acid hirudin analogue and direct thrombin inhibitor for DVT prophylaxis after hip or knee replacement; EU authorization withdrawn 2014.
Deslanoside
Deslanoside (deacetyllanatoside C, Cedilanid-D) is a Digitalis lanata cardiac glycoside for heart failure and supraventricular arrhythmias; Na-K-ATPase inhibitor, half-life 38-77 h, discontinued in the US but available in Brazil, China, and Japan.
Desminopathy
Desminopathy (desmin-related myofibrillar myopathy, MFM1, OMIM 601419) is a rare genetic muscle disease caused by DES gene mutations, causing progressive distal-onset weakness, cardiomyopathy, and respiratory insufficiency.
Desmodium styracifolium total flavonoids capsules
Desmodium styracifolium total flavonoids capsules (广金钱草总黄酮胶囊, Guang Jing) are a Chinese category 1.2 TCM drug approved in 2022 for ureteral stones with damp-heat pattern; phase 3 trial showed 44.6% vs 33.8% stone passage by day 28.
Desmoglein-2
Desmoglein-2 (DSG2) is a cardiac desmosomal cadherin at 18q12 whose variants cause arrhythmogenic cardiomyopathy, accounting for roughly 2.5–10% of cases, with founder variant p.Phe531Cys common in China.
Desmoid tumor
Desmoid tumor (desmoid-type fibromatosis, aggressive fibromatosis): a rare, locally aggressive, non-metastasizing fibroblastic soft-tissue tumor driven by CTNNB1 or APC mutations, now managed first with active surveillance, with nirogacestat approved in 2023.
Desmoplakin
Desmoplakin (DSP): plakin-family protein anchoring intermediate filaments to cardiac and skin desmosomes. DSP gene mutations cause desmoplakin cardiomyopathy, a left-dominant, fibrotic, inflammation-prone arrhythmogenic cardiomyopathy distinct from PKP2 disease, plus Carvajal and Naxos syndromes.
Desmoplastic infantile astrocytoma/ganglioglioma
Desmoplastic infantile astrocytoma/ganglioglioma (DIA/DIG, ICD-O 9412/1) is a rare WHO grade 1 infant brain tumor, a large cystic supratentorial desmoplastic mass driven by BRAF/RAF1 MAPK alterations, treated mainly by surgery with favorable prognosis.
Desmoplastic small round cell tumor
Desmoplastic small round cell tumor (DSRCT), also DSRCT, an ultra-rare aggressive sarcoma of young males defined by t(11;22)(p13;q12) EWSR1::WT1 fusion, presenting as abdominopelvic nodules with 5-year survival of 10-20%.
Desmopressin
Desmopressin (DDAVP, 1-deamino-8-D-arginine vasopressin), synthetic V2-agonist analog of vasopressin synthesized 1967; treats central diabetes insipidus, enuresis, nocturia, and bleeding disorders; main risk hyponatremia.
Desmosterolosis
Desmosterolosis (OMIM 602398), an ultra-rare autosomal recessive cholesterol biosynthesis disorder caused by DHCR24 mutations, with desmosterol accumulation, congenital anomalies, spasticity, and intellectual disability; about 9 reported cases.
Desmoteplase
Desmoteplase (DSPAα1), a fibrin-selective plasminogen activator from vampire bat (Desmodus rotundus) saliva, was developed as a 3-9 hour window stroke thrombolytic; trials showed recanalization gains but no functional benefit.
Desogestrel
Desogestrel, a third-generation synthetic progestogen prodrug of etonogestrel, used in the 75-microgram progestogen-only pill (Cerazette) and combined oral contraceptives; 12-hour missed-pill window, 2026 EMA meningioma warning.
Desomorphine
Desomorphine (krokodil, крокодил) is a semi-synthetic opioid about ten times more potent than morphine, first synthesized in 1932, sold briefly as Permonid, and now infamous as the homemade codeine-based street drug krokodil causing severe tissue necrosis; Schedule I in the US.
Desoside-P (LL-4218)
Desoside-P (LL-4218) was Lupin Ltd's oral, plant-derived investigational drug for chronic stable plaque psoriasis, approved for Indian Phase II trials by the DCGI in July 2006; later pipeline disclosures no longer list it.
Desoximetasone
Desoximetasone (Topicort) is a synthetic fluorinated topical corticosteroid for psoriasis, eczema, and other dermatoses; US cream approved 1977, 0.25% spray 2013, class I–III potency.
Desoxycorticosterone acetate
Desoxycorticosterone acetate (DOCA, deoxycorticosterone acetate) is a synthetic mineralocorticoid ester synthesized in 1937, introduced as an oily injection for Addison's disease in 1939, later superseded by fludrocortisone.
Desquamation
Desquamation is the shedding of corneocytes from the stratum corneum, driven by kallikrein-mediated corneodesmosome degradation; impaired or excessive shedding causes scaling disorders like ichthyosis and Netherton syndrome.