25,729 articles
DEVOTE trial
DEVOTE (NCT01959529) was a 2017 Novo Nordisk-funded cardiovascular outcomes trial in 7637 type 2 diabetes patients showing insulin degludec noninferior to glargine U100 for MACE (HR 0.91) with less severe hypoglycemia.
Dewi Evans
Dewi Evans, or Dewi Richard Evans, is a retired British consultant pediatrician at Singleton Hospital, Swansea, and lead prosecution expert witness in the 2023 Lucy Letby trial.
DEX-SNS-SEPSIS trial
DEX-SNS-SEPSIS (NCT07470775) is a Phase 4, triple-masked randomized trial of early dexmedetomidine 0.5 μg/kg/h versus placebo for 48 hours in 168 adults with Sepsis-3 septic shock, using heart rate variability as the primary endpoint.
Dexamethasone
Dexamethasone: potent synthetic glucocorticoid (Decadron), ATC H02AB02, 0.75 mg equals 5 mg prednisone; RECOVERY trial 6 mg daily cut COVID-19 mortality in oxygen-requiring patients; WHO-recommended for severe COVID-19.
Dexamethasone suppression test
Dexamethasone suppression test (DST, Liddle test): endocrine test giving dexamethasone and measuring cortisol to detect Cushing's syndrome and mild autonomous cortisol secretion; 1-mg overnight form has 98.6% sensitivity, 90.6% specificity.
Dexamyl
Dexamyl (Drinamyl in the UK) was a Smith, Kline & French combination of dextroamphetamine and amobarbital, launched in 1950 for depression, anxiety, and obesity; the most prescribed amphetamine product of its era, withdrawn after FDA action in 1976.
Dexbrompheniramine
Dexbrompheniramine, also called D-brompheniramine or Disomer, is the dextrorotary stereoisomer of the alkylamine antihistamine brompheniramine; its maleate salt, first approved in 1963, treated hay fever and cold symptoms in products such as Drixoral.
Dexchlorpheniramine
Dexchlorpheniramine (Polaramine) is the S-enantiomer of chlorpheniramine, a first-generation sedating H1 antihistamine about twice as active as the racemate, used for allergic rhinitis, conjunctivitis, and urticaria.
Dexfenfluramine
Dexfenfluramine (Redux) is the purified d-enantiomer of fenfluramine, a serotonergic appetite suppressant approved in 1996 for obesity and withdrawn in 1997 over heart valve disease.
Dexibuprofen
Dexibuprofen, or S(+)-ibuprofen, is the active single-enantiomer form of the NSAID ibuprofen, used for pain, inflammation, and fever with a lower risk of adverse events than ibuprofen.
Dexketoprofen
Dexketoprofen, also called dexketoprofen trometamol (Keral), is the active S-(+) enantiomer of ketoprofen, an NSAID for mild to moderate pain; approved in Europe (oral 1998, injectable 2002) but not by the US FDA.
Dexloxiglumide
Dexloxiglumide (CR-2017), the (R)-isomer of loxiglumide, is a selective CCK1/CCKA receptor antagonist developed by Rotta for IBS-C; it accelerates gastric emptying but failed large phase 3 IBS trials.
Dexmecamylamine
Dexmecamylamine (TC-5214, S-(+)-mecamylamine), a nicotinic channel modulator by Targacept and AstraZeneca; failed four Phase III trials as an antidepressant adjunct and was discontinued.
Dexmedetomidine
Dexmedetomidine (Precedex) is a selective alpha-2 adrenergic agonist sedative for ICU and procedural sedation; approved 1999, it preserves respiratory drive, reduces delirium, and causes bradycardia and hypotension.
Dexmethylphenidate
Dexmethylphenidate (Focalin, Focalin XR) is the d-threo enantiomer of methylphenidate, a schedule II CNS stimulant for ADHD in adults and children, dosed at half the racemic methylphenidate dose.
Dexpramipexole
Dexpramipexole (KNS-760704, BIIB050), the R(+) enantiomer of pramipexole, is an oral small molecule that failed phase 3 testing in ALS (EMPOWER) and is now developed as an eosinophil-lowering therapy for eosinophilic asthma.
Dexrazoxane
Dexrazoxane (Zinecard, Totect, Savene), a bisdioxopiperazine EDTA analog and topoisomerase II inhibitor, is the only approved drug for preventing anthracycline cardiotoxicity and for treating anthracycline extravasation.
Dextranomer
Dextranomer (Debrisan, Deflux, Solesta) is a cross-linked dextran polymer used as wound-cleansing beads and, with hyaluronic acid, as an injectable bulking agent for vesicoureteral reflux and fecal incontinence.
Dextrocardia
Dextrocardia: congenital condition in which the heart sits in the right chest, pointing right; also called mirror-image heart with situs inversus. Occurs in about 1 in 12,000 pregnancies; isolated cases are benign, but situs solitus or ambiguous forms carry frequent complex heart defects.
Dextromethorphan
Dextromethorphan (DXM, Romilar), a morphinan NMDA antagonist and sigma-1 agonist: OTC cough suppressant since 1958, and prescription drug in Nuedexta (pseudobulbar affect) and Auvelity (depression, Alzheimer's agitation).
Dextromoramide
Dextromoramide (Palfium, Jetrium) is a synthetic methadone-related opioid analgesic, C25H32N2O2, more potent but shorter-acting than morphine; formerly used for severe pain, now DEA Schedule I and discontinued in Europe.
Dextropropoxyphene
Dextropropoxyphene, a weak synthetic opioid analgesic (d-isomer of propoxyphene, co-proxamol with paracetamol), withdrawn from EU, US, and UK markets 2005-2010 over fatal overdose risk.
Dextrose prolotherapy
Dextrose prolotherapy is an injection therapy in which hypertonic dextrose solution, typically 12.5% to 25%, is injected into tendons, ligaments, or joints to treat chronic musculoskeletal pain.
Dextrothyroxine
Dextrothyroxine (D-thyroxine, Choloxin) is the D-enantiomer of thyroxine, an antihyperlipidemic approved in 1967 and withdrawn after the Coronary Drug Project showed excess deaths in its dextrothyroxine arm.
Dezocine
Dezocine (Dalgan) is a synthetic mixed agonist-antagonist opioid analgesic, a partial biased μ-receptor agonist and mixed κ agonist-antagonist with norepinephrine reuptake inhibition, used mainly in China for postoperative pain and unscheduled in the US.
DFG trial
DFG trial (NCT03582540), Early Versus Delayed Double-guidewire Technique in Difficult Biliary Cannulation: French multicenter randomized ERCP trial by Société Française d'Endoscopie Digestive; early double-guidewire use achieved 84% vs 50% cannulation within 10 minutes.
Dhanvantara ghrta
Dhanvantara ghrta, also spelled Dhanwantara Ghrita, is a classical Ayurvedic medicated ghee used mainly for urinary disorders (Prameha) and related skin eruptions, abscesses, and swellings.
Dhanvantara gutika
Dhanvantara gutika (Dhanvantari gutika, Dhanwantaram gulika), Ayurvedic Formulary of India formulation AFI000247, is a classical herbal pill used for cough, dyspnea, heart disease, tuberculosis, and hiccup at 250–500 mg doses.
Dhanvantara taila
Dhanvantara taila (Dhanwantaram Thailam, synonym Bala taila) is a classical Ayurvedic medicated sesame oil cooked with Sida cordifolia decoction, milk, and dashamula herbs, used for Vata disorders, postnatal care, and children.
Dhanyapancaka kvatha curna
Dhanyapancaka kvatha curna (Dhānyapañcaka kvātha cūrṇa), AFI000632, is a five-herb Ayurvedic decoction powder (coriander, ginger, musta, Coleus vettiveroides, bael) dosed 48 g in divided doses for ama diarrhea, colic, and anorexia.