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Human health and medicine

25,729 articles

Hawkinsinuria

Hawkinsinuria (4-HPPD deficiency, OMIM 140350) is a rare autosomal dominant tyrosine metabolism disorder caused by HPD gene variants, causing infantile failure to thrive, metabolic acidosis, sparse hair, and lifelong urinary hawkinsin excretion.

Hayatabad Medical Complex

Hayatabad Medical Complex (HMC), Peshawar, a public tertiary care Medical Teaching Institution in Hayatabad, Peshawar, Khyber Pakhtunkhwa, Pakistan, with PGMI, IKD, PICO, and KGMC units, over 1,280 beds, and millions of patients treated yearly.

Hayley Okines

Hayley Leanne Okines (1997-2015), English progeria campaigner known as the 100-year-old teenager; wrote Old Before My Time and Young at Heart, joined Boston drug trials, died at 17 of pneumonia.

Hazelden Betty Ford Foundation

Hazelden Betty Ford Foundation: nonprofit US addiction and mental health treatment provider formed by the 2014 merger of Hazelden (1949) and the Betty Ford Center (1982), headquartered in Center City, Minnesota, serving 30,000+ patients yearly across 15 locations in nine states.

HB0017 (IL-17A antibody)

HB0017 is a humanized IgG1 monoclonal antibody against IL-17A by Shanghai Huaota (Huahai Pharmaceutical) for plaque psoriasis and ankylosing spondylitis; phase III met all endpoints and NMPA accepted its NDA.

HBM7008 (B7-H4 x 4-1BB bispecific)

HBM7008 (CLN-418), Harbour BioMed's fully human B7-H4 x 4-1BB bispecific immune activator from the HBICE platform; Phase 1 in advanced solid tumors, licensed to Cullinan in 2023 for $25M upfront, terminated and returned in 2024.

HBM7022 (Claudin 18.2 x CD3 bispecific)

HBM7022 (AZD5863) is Harbour BioMed's fully human Claudin 18.2 x CD3 bispecific T-cell engager antibody, out-licensed globally to AstraZeneca in April 2022 for $25M upfront plus up to $325M milestones, now in Phase I solid tumor trials.

HBM9033 (MSLN ADC)

HBM9033 (PF-08052666, SGN-MesoC2) is a mesothelin-targeted antibody-drug conjugate with a camptothecin-based topoisomerase 1 inhibitor payload, DAR 8, developed by Harbour BioMed/Nona Biosciences, licensed to Pfizer for $53 million upfront plus up to $1.05 billion milestones, and discontinued in 2026 after a terminated Phase 1 trial.

HbSC disease

HbSC disease is a compound heterozygous sickling hemoglobinopathy, milder than sickle cell anemia in anemia and stroke risk, yet prone to retinopathy, splenomegaly, and avascular necrosis.

HCA Healthcare

HCA Healthcare (NYSE: HCA), formerly Hospital Corporation of America, is a Nashville-based for-profit hospital operator founded in 1968 by the Frists and Jack Massey; 190 hospitals, $75.6B 2025 revenue, largest US for-profit hospital chain.

HCHS study

The Hamburg City Health Study (HCHS) is a large cohort study by the University Medical Center Hamburg-Eppendorf following 45,000 Hamburg residents to find chronic disease risk factors.

HCHS/SOL study

HCHS/SOL (Hispanic Community Health Study/Study of Latinos) is the largest US longitudinal cohort study of Hispanic/Latino health: 16,415 adults aged 18–74 at Bronx, Chicago, Miami, and San Diego centers, baseline 2008–2011, with ancillary studies and genotyping.

HCSVD-TRC study

HCSVD-TRC (NCT06512376) is a Beijing Tiantan Hospital observational patient registry of hereditary cerebral small vessel disease, led by Yilong Wang, enrolling 100 gene-confirmed or suspected hCSVD patients for 5-year genetic, MRI, and clinical follow-up, 2022 to 2027.

HDacro trial

HDacro trial (NCT00461149), Federico II University Naples, Colao: 24-month open-label phase 4 study of octreotide-LAR dose escalation (20 to 40 mg q28d) as first-line acromegaly therapy, achieving 80.3% biochemical control and 68% tumor shrinkage.

Head

Head: the uppermost part of the human body, containing the brain in its 22-bone skull (cranium), the face, and sensory organs; divided into neurocranium and viscerocranium, joined by sutures.

Head and neck cancer

Head and neck cancer: group of cancers of the mouth, throat, larynx, sinuses, nasal cavity, and salivary glands, mostly squamous cell carcinomas; driven by tobacco, alcohol, and HPV, with rising HPV-related oropharyngeal incidence.

Head drop

Head drop (dropped head syndrome, 首下がり症候群; ICD-11 MB45.3): chin-on-chest posture from neck extensor muscle weakness, caused by ALS, myasthenia gravis, parkinsonism, or isolated neck extensor myopathy; treated medically or surgically.

Head impulse test

The head impulse test, also called the head thrust test, is a bedside maneuver that assesses the vestibulo-ocular reflex to detect unilateral inner-ear balance dysfunction.

Head injury

Head injury is trauma to the scalp, skull, or brain, excluding the face and jaws. Also called traumatic brain injury when the brain is affected; graded mild, moderate, or severe by the Glasgow Coma Scale, with primary and secondary injury phases.

Head Movements

Head movements: voluntary or involuntary motion of the head in humans and animals (MeSH D019416). Covers gaze stabilization via the vestibulo-ocular reflex, head impulse testing, active versus passive movement effects, and nonverbal communication roles.

Head Protective Devices

Head protective devices are helmets and hard hats that absorb impact energy to reduce head injury in military, industrial, road, and sport settings, spanning steel M1 combat helmets, ANSI Z89.1 and ISO 3873 industrial standards, and rotational-protection technologies like MIPS.

Head transplant

Head transplant, also called whole-body transplantation, is an experimental procedure attaching a living head with its brain to a donor body. Performed partially in dogs, mice, and Robert White's 1970 rhesus monkeys (nine-day survival); proposed for humans by Sergio Canavero, with a 2017 cadaver rehearsal, but spinal cord fusion remains unsolved.

Head-down tilt

Head-down tilt is a positioning method with the head below the feet, used in space medicine to simulate weightlessness, typically at -6° for days to weeks.

Head-related transfer function

Head-related transfer function (HRTF): direction-dependent acoustic filter of sound by a listener's head, pinnae, and torso, measured at the ear canal entrance; listener-specific like a fingerprint, basis of binaural VR audio, carrying ITD, ILD, and spectral localization cues.

Headache

Headache: pain in the head or upper neck; headache disorders include primary types (migraine, tension-type, cluster), secondary types such as medication-overuse headache, and affect about 40% of the global population.

Healed venous leg ulcer

Healed venous leg ulcer: a venous stasis ulcer whose skin has fully re-epithelialized. Recurrence reaches 50-70% within five years; prevention relies on compression stockings, leg elevation, and ablation of superficial venous reflux.

HEALIVE

HEALIVE (孩尔来福) is Sinovac's inactivated hepatitis A vaccine using the TZ84 strain in 2BS human diploid cells; China-approved 2002, WHO-prequalified 2017, two-dose pediatric 250 U and adult 500 U schedule.

Health

Human health: the WHO-defined state of complete physical, mental and social well-being, not merely absence of disease. Covers determinants (social, environmental, commercial), measurement, health assessments, and 2026 global SDG status.

Health administration

Health administration: leadership and management of healthcare organizations by medical and health services managers (healthcare executives). Covers MHA/MBA/FACHE credentials, 640,400 US jobs at $123,860 median pay, 15–30% administrative cost share, and multi-payer versus single-payer differences.

Health and appearance of Michael Jackson

Health and appearance of Michael Jackson: the pop star's vitiligo and lupus diagnoses, 1984 Pepsi scalp burns, depigmentation with Benoquin, plastic surgery, and his 2009 death and autopsy findings.