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Human health and medicine

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Infantile-onset X-linked spinal muscular atrophy

Infantile-onset X-linked spinal muscular atrophy (SMAX2, or XL-SMA) is a rare, typically lethal X-linked recessive disorder caused by UBA1 mutations, marked by congenital hypotonia, contractures, and respiratory failure.

Infarction

Infarction: localized tissue necrosis from ischemia due to blocked blood supply, usually thrombus or embolus. Covers white and red infarcts, myocardial and cerebral infarction, MI definitions, and reperfusion treatment windows.

Infarction of liver

Infarction of liver, or hepatic infarction, is death of liver tissue from reduced blood supply through the hepatic artery, the portal vein, or both, and is rare.

Infected epidermoid cyst

Infected epidermoid cyst (ICD-11 EK70.00), also called infected sebaceous or epidermal inclusion cyst: a keratin-filled skin cyst secondarily infected, usually by Staphylococcus aureus; most red, swollen cysts are actually sterile inflammation from rupture, treated by incision and drainage.

Infected hydrocele

Infected hydrocele, also called pyocele, is an infected, inflamed hydrocele sac around the testis (ICD-11 GB00.1, ICD-10 N43.1), usually arising from orchitis, epididymitis, or abscess, treated with antibiotics and surgery or drainage.

Infected ingrowing toenail

Infected ingrowing toenail (ICD-11 EE13.11, onychocryptosis with infection): nail plate pierces the nail fold, causing pain, pus, and inflammation; treated with soaks, antibiotics, and nail surgery with phenolisation.

Infection

Infection: invasion and multiplication of pathogens (bacteria, viruses, fungi, parasites) in a host. Covers germ theory (Pasteur, Koch), host immune response, sepsis, CDC isolation precautions, and WHO surveillance of respiratory infections.

Infection Control

Infection control, or infection prevention and control (IPC), is the discipline of practices preventing infection spread in healthcare settings, built on Standard Precautions for all patients and Transmission-Based Precautions (contact, droplet, airborne) for known or suspected infections.

Infection of amputation stump

Infection of amputation stump (stump infection) is infection of the residual limb after amputation, coded ICD-11 NE85.4 and ICD-10 T87.4. Rates range from about 11% to 60% by setting; risks include crushing injury, transtibial level, and prolonged prosthesis wear.

Infection of obstetric surgical wound

Infection of obstetric surgical wound is infection of a surgical incision made during childbirth surgery, most often a cesarean section wound, occurring in about 5.6% of cesarean deliveries.

Infection of spleen

Infection of spleen (ICD-11 3B81.7), chiefly splenic abscess and acute septic splenitis: rare bacterial, fungal, or parasitic splenic infection, 0.1–0.7% incidence, treated with antibiotics, percutaneous drainage, or splenectomy.

Infection with tilapia lake virus

Infection with tilapia lake virus (TiLV disease, syncytial hepatitis of tilapia): a WOAH-listed contagious RNA virus disease of farmed and wild tilapia causing 10–90% mortality, liver and brain lesions, spread by horizontal and vertical transmission, with no commercial vaccine.

Infection-related hemolytic uremic syndrome

Infection-related (typical, post-diarrheal) hemolytic uremic syndrome: a thrombotic microangiopathy with thrombocytopenia, hemolytic anemia, and kidney injury, caused mainly by Shiga toxin-producing E. coli in children.

Infections in the puerperium

Infections in the puerperium are bacterial infections of the genital tract or surrounding tissues after childbirth, in the six weeks during which the uterus returns to its original size.

Infections of kidney in pregnancy

Infections of kidney in pregnancy (ICD-11 JA62.0), chiefly acute pyelonephritis, occur in 1–2% of pregnancies, peak in the second trimester, require inpatient IV antibiotics with a 14-day course, and recur in up to 25% before delivery.

Infections of the lacrimal gland

Infections of the lacrimal gland (infectious dacryoadenitis): viral, mainly Epstein-Barr virus, or bacterial, mainly Staphylococcus aureus including MRSA; abscess may need drainage with IV antibiotics.

Infectious anterior uveitis

Infectious anterior uveitis is inflammation of the eye's anterior segment, the iris and adjacent structures, caused by an active infection requiring antimicrobial or antiviral treatment.

Infectious blepharitis

Infectious blepharitis, ICD-11 9A01.3 (感染性眼瞼炎), is bacterial infection of the eyelid margin causing itching, tearing, and lash crusting; spread by contact, endogenous spread, or fomites, and treated with lid hygiene plus antibiotics.

Infectious bursitis

Infectious (septic) bursitis, ICD-11 FB50.0, is bursal inflammation caused by an infectious agent, usually Staphylococcus aureus, most often at the olecranon or prepatellar bursa, diagnosed by aspiration and treated with anti-staphylococcal antibiotics.

Infectious cystitis

Infectious cystitis (ICD-11 GC00.1), bladder inflammation caused by microbes, usually E. coli ascending the urethra; the most common UTI, with dysuria, urgency, frequency, and hematuria, treated with nitrofurantoin or fosfomycin.

Infectious dermatitis

Infectious dermatitis (infective eczematoid dermatitis, ICD-11 EA88.0): acute exudative eczematous eruption around a suppurative infection focus, mainly S. aureus, treated with topical antibiotics and soaks.

Infectious disease

Infectious disease is disease caused by a microorganism or other infectious agent in a human host; formally classified as DOID:0050117 and Mondo 0005550, it is studied through the Reactome pathway R-HSA-5663205.

Infectious diseases

Infectious diseases (ID), also called communicable diseases medicine, is the non-procedural medical specialty covering pathogenesis, diagnosis, treatment, and epidemiology of infections; its knowledge base exceeds comparable specialties and 80% of US counties lack an ID physician.

Infectious duodenitis

Infectious duodenitis, ICD-11 DA51.6, is duodenal mucosal inflammation caused by bacteria, viruses, fungi, or parasites; H. pylori is the most common cause, with giardiasis, tuberculosis, CMV, and MAI among others.

Infectious epithelial keratitis

Infectious epithelial keratitis: rare, sight-threatening inflammation of the corneal epithelium from viral (mainly HSV-1), bacterial, fungal, or protist infection; dendritic ulcers; treated with oral acyclovir, valacyclovir, or topical antivirals.

Infectious intermediate uveitis

Infectious intermediate uveitis (ICD-11 9B66.1): infection-driven inflammation of the vitreous and peripheral retina, caused mainly by syphilis, tuberculosis, and Lyme disease, diagnosed by PCR, serology, and mNGS.

Infectious intracranial aneurysm

Infectious intracranial aneurysm, also called mycotic aneurysm: an infected, rupturing-prone pseudoaneurysm of intracranial arteries, usually from septic emboli in infective endocarditis; treated with antibiotics, surgery, or endovascular occlusion.

Infectious keratitis

Infectious keratitis, also called microbial or infective corneal ulcer, is corneal infection by bacteria, fungi, viruses, or Acanthamoeba; the leading cause of corneal blindness, diagnosed by scraping, culture, PCR, and confocal microscopy.

Infectious liver disease

Infectious liver disease is liver inflammation and damage caused by pathogens, chiefly hepatitis viruses A, B, C, D, and E plus bacterial, amoebic, and fungal liver abscess. HBV and HCV cause most chronic disease and about 1.3 million deaths yearly.

Infectious myocarditis

Infectious myocarditis (ICD-11 BC42.1), inflammation of the heart muscle from viral, bacterial, or parasitic antigens. Viruses predominate; parvovirus B19 and HHV-6 in high-income countries, dengue, HIV, malaria, and Chagas elsewhere.