25,729 articles
4q21 microdeletion syndrome
4q21 microdeletion syndrome (Del(4)(q21), monosomy 4q21) is a rare de novo interstitial deletion of chromosome 4q21 causing facial dysmorphism, growth restriction, severe intellectual deficit, and absent speech; critical genes PRKG2 and RASGEF1B.
4q25 proximal deletion syndrome
4q25 proximal deletion syndrome (ORPHA:502437, proximal del(4)(q25)) is an ultra-rare autosomal dominant chromosomal disorder from deletions 675 kb proximal to PITX2, causing developmental delay, behavioral difficulties, hypotelorism, and mandibular asymmetry, distinct from Axenfeld-Rieger syndrome.
5-HT1A receptor
5-HT1A receptor: inhibitory Gi/o-coupled serotonin GPCR acting as raphe autoreceptor and postsynaptic heteroreceptor; target of buspirone, gepirone, vilazodone, and WAY-100635 in anxiety and depression research.
5-Hydroxytryptophan
5-Hydroxytryptophan (5-HTP, oxitriptan), the immediate serotonin precursor formed from tryptophan by tryptophan hydroxylase; sold as a supplement from Griffonia simplicifolia seeds, studied for depression, with contaminant-related EMS history.
5-oxoprolinase deficiency
5-oxoprolinase deficiency is an extremely rare autosomal recessive inborn error of glutathione metabolism, caused by OPLAH variants, that causes persistent 5-oxoprolinuria; its clinical significance is debated.
56 Dean Street
56 Dean Street (56DS) is a free NHS sexual health and HIV clinic in Soho, London, run by Chelsea and Westminster Trust since 2009, with rapid-testing sister site Dean Street Express (2014), TransPlus gender services, and HIV diagnoses down over 80% from the 2015 peak.
5A2-SC8
5A2-SC8 is a degradable, dendrimer-based ionizable amino lipid, selected from a library of over 1,500 candidates, whose lipid nanoparticles deliver siRNA, mRNA, and CRISPR-Cas9 cargoes, primarily to the liver.
5p13 microduplication syndrome
5p13 microduplication syndrome (Dup(5)(p13), trisomy 5p13, OMIM 613174) is a rare contiguous-gene duplication disorder of chromosome 5p13 involving NIPBL, causing developmental delay, hypotonia, macrocephaly, and facial dysmorphism.
5q35 microduplication syndrome
5q35 microduplication syndrome (Dup(5)(q35), trisomy 5q35) is a rare chromosomal duplication of 5q35 including NSD1, reciprocal to the Sotos syndrome deletion, causing microcephaly, short stature, developmental delay, and delayed bone age.
5yrGH study
5yrGH (NCT00462475), Effect of 5 Years of GH Replacement on Atherosclerosis, a phase 4 observational study at Federico II University, Naples, led by Annamaria Colao, showing 5 years of GH replacement reduced carotid IMT and insulin-resistance syndrome in men with severe GHD.
5α-Reductase 2 deficiency (αR2D)
5α-Reductase 2 deficiency (5α-RD2, PPSH) is a rare autosomal recessive 46,XY disorder of sex development caused by SRD5A2 mutations impairing testosterone-to-DHT conversion, causing undervirilized external genitalia with pubertal virilization.
6-Methylnicotine
6-Methylnicotine (6MN, Metatine, Nixodine) is a synthetic nicotine analog, C11H16N2, with an extra methyl on the pyridine ring; it activates nicotinic receptors, appears in Spree Bar vapes, evades FDA tobacco rules, and shows distinct metabolism and toxicity from nicotine.
609A (anti-PD-1 antibody)
609A (609-A) is a recombinant humanized IgG4 kappa anti-PD-1 monoclonal antibody developed by 3SBio's Sunshine Guojian, licensed globally to Syncromune in 2022 for the Syncrovax/SYNC-T SV-102 intratumoral immunotherapy, with Chinese phase II trials and a heavy-chain-dominant PD-1 binding structure (PDB 7VUX).
661W
661W is an immortalized mouse cone photoreceptor-like cell line cloned from retinal tumors, the most widely used cell model for retinal disease research, drug screening, and gene therapy development.
6q terminal deletion syndrome
6q terminal deletion syndrome, also called terminal 6q deletion, is a rare chromosomal disorder from loss of the end of chromosome 6q (6q26-q27), causing craniofacial dysmorphism, developmental delay, intellectual disability, hypotonia, seizures, and brain anomalies; DLL1 haploinsufficiency is the principal mechanism.
7+3 chemotherapy
7+3 chemotherapy is the standard intensive induction regimen for acute myeloid leukemia, combining 7 days of continuous-infusion cytarabine with 3 days of daunorubicin or idarubicin.
7p22.1 microduplication syndrome
7p22.1 microduplication syndrome (Dup(7)(p22.1), Trisomy 7p22.1, ORPHA:314034) is a rare chromosomal disorder from interstitial duplication of chromosome band 7p22.1, causing intellectual disability, speech delay, macrocephaly, hypertelorism, and cryptorchidism, with a 430 kb critical region including ACTB.
7q11.23 microduplication syndrome
7q11.23 microduplication syndrome (Dup7, Dup(7)(q11.23)) is a rare autosomal dominant disorder from duplication of the Williams-Beuren critical region, causing speech delay, hypotonia, behavioral problems, aortic dilatation, and distinctive facial features.
884 trial
The 884 trial (NCT00579709), Thymus Transplantation With Immunosuppression, was a Duke Phase 1 study of Thymoglobulin, cyclosporine, and cultured thymus tissue for complete DiGeorge anomaly patients able to reject grafts.
8p inverted duplication/deletion syndrome
8p inverted duplication/deletion syndrome (invdupdel(8p)) is a rare chromosome 8p rearrangement causing intellectual disability, hypotonia, corpus callosum agenesis, heart and skeletal defects, arising de novo via REPD/REPP-mediated recombination.
8p23.1 duplication syndrome
8p23.1 duplication syndrome (dup(8)(p23.1p23.1), trisomy 8p23.1) is a rare genomic disorder from a 3.68 Mb duplication of chromosome 8p23.1 involving SOX7 and GATA4, causing developmental delay, dysmorphism, and congenital heart disease.
8p23.1 microdeletion syndrome
8p23.1 microdeletion syndrome, also called monosomy 8p23.1, is a rare chromosomal disorder caused by a deletion on chromosome 8, with heart defects and intellectual deficit.
8q21.11 microdeletion syndrome
8q21.11 microdeletion syndrome (Del(8)(q21.11), OMIM 614230) is an ultra-rare autosomal dominant disorder from heterozygous 8q21.11 deletions, causing intellectual disability, facial dysmorphism, hypotonia, and hearing loss; ZFHX4 is the main driver gene.
9MW0311, denosumab biosimilar (Prolia reference)
9MW0311 (Mailishu, 迈利舒) is Mabwell's denosumab biosimilar of Prolia, a fully human anti-RANKL monoclonal antibody for postmenopausal osteoporosis, approved in China in March 2023 and in Pakistan in 2025.
9MW3011 (iron-homeostasis antibody)
9MW3011 (DISC-3405, MWTX-003) is a humanized anti-TMPRSS6 monoclonal antibody by Mabwell that raises hepcidin to restrict iron; licensed to Disc Medicine in 2023 for up to $412.5 million, now in Phase 2 for polycythemia vera.
9p13 microdeletion syndrome
9p13 microdeletion syndrome (Del(9)(p13), monosomy 9p13) is a rare chromosomal disorder from an interstitial deletion at 9p13, causing mild to moderate developmental delay, hand tremors, myoclonic jerks, ADHD, a social personality, short stature, and precocious puberty.
9q21.13 microdeletion syndrome
9q21.13 microdeletion syndrome, also called 9q21 microdeletion syndrome, is a rare chromosomal disorder causing intellectual disability, speech delay, epilepsy, autistic behavior, and facial dysmorphism; the 750 kb critical region includes RORB.
A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo
A 2018 Nature Biotechnology paper by Suping Li and colleagues in Beijing reporting a DNA origami nanorobot that delivers thrombin to tumor vessels in mice.
A Million Little Pieces
A Million Little Pieces is James Frey's 2003 addiction memoir, published by Nan A. Talese/Doubleday, an Oprah's Book Club bestseller exposed in 2006 by The Smoking Gun as partly fabricated and now classed as a novel.
A molecular robot that can detect and kill cancer cells
A molecular robot that can detect and kill cancer cells is a DNA-built nanoscale device that senses tumor markers and acts, demonstrated so far only in mice.