25,729 articles
Pegtibatinase
Pegtibatinase (OT-58, TVT-058) is a PEGylated truncated human cystathionine beta-synthase enzyme replacement therapy for classical homocystinuria, in Phase 3 (HARMONY) by Travere Therapeutics, cutting plasma total homocysteine about 67% in COMPOSE.
Pegunigalsidase alfa
Pegunigalsidase alfa (Elfabrio, pegunigalsidase alfa-iwxj) is a PEGylated recombinant alpha-galactosidase A enzyme replacement therapy made in tobacco cells, approved in 2023 for adults with Fabry disease, dosed 1 mg/kg IV every 2 weeks, noninferior to agalsidase beta in the BALANCE trial.
Pegvaliase
Pegvaliase (Palynziq, pegvaliase-pqpz) is a PEGylated bacterial phenylalanine ammonia lyase injected subcutaneously for phenylketonuria with Phe >600 micromol/L; FDA approved 2018, EU 2019, extended to ages 12+ in 2026.
Pegvisomant
Pegvisomant (Somavert) is a PEGylated growth hormone receptor antagonist approved in 2003 for acromegaly uncontrolled by surgery or radiation; daily subcutaneous injection normalizing IGF-1, with real-world control around 62–71%.
PEGylated nanographene
PEGylated nanographene is nanoscale graphene oxide grafted with polyethylene glycol, giving water solubility, longer blood circulation, and passive tumor targeting; it remains limited to preclinical cancer drug delivery research.
Pegzilarginase
Pegzilarginase (Loargys, pegzilarginase-nbln) is a pegylated recombinant human arginase 1 enzyme, dosed weekly IV or subcutaneously, that lowers plasma arginine in arginase 1 deficiency (hyperargininemia); EU-approved 2023, FDA accelerated approval 2026.
PEHO syndrome
PEHO syndrome (progressive encephalopathy with edema, hypsarrhythmia, optic atrophy) is a rare infantile genetic disorder with extreme cerebellar atrophy, first described in Finnish patients, caused chiefly by ZNHIT3 mutations but genetically heterogeneous.
PEHO-like syndrome
PEHO-like syndrome (ORPHA:99807, OMIM 617507) is a rare genetic infantile encephalopathy with hypsarrhythmic seizures, edema, hypotonia, and dysmorphism, but lacking the optic atrophy and cerebellar atrophy of PEHO syndrome; genetically heterogeneous.
PEI-PEG polyplex
A PEI-PEG polyplex is a non-viral gene delivery particle in which polyethylenimine (PEI) condenses nucleic acids and a polyethylene glycol (PEG) shell reduces toxicity, aggregation, and blood clearance.
Peking Union Medical College Hospital
Peking Union Medical College Hospital (北京协和医院, PUMCH), founded by the Rockefeller Foundation in 1921 in Beijing, is a Class A tertiary comprehensive hospital, national center for complex and rare diseases, and China's top-ranked teaching hospital.
Peking University First Hospital
Peking University First Hospital (北京大学第一医院, Beida Hospital), founded 15 February 1915 in Beijing, is China's earliest founded hospital, a tertiary Grade A teaching hospital of Peking University known for urology, nephrology, dermatology, and pediatrics, with 2,480 beds and a Daxing campus opened in 2023.
Peking University People's Hospital
Peking University People's Hospital (北京大学人民医院), founded 1918 as China's first Chinese-financed general hospital, is a Peking University teaching hospital in Beijing with 2,600+ beds, two national research centers, and a Xiong'an branch.
Peking University Third Hospital
Peking University Third Hospital (北京大学第三医院, PUTH), founded 1958 in Beijing's Haidian District, is a National Health Commission-managed tertiary Grade-A hospital and Peking University clinical school, known for spine surgery, reproductive medicine (mainland China's first IVF baby), and sports medicine.
Pelacarsen
Pelacarsen (TQJ230, AKCEA-APO(a)-LRx) is a GalNAc-conjugated antisense oligonucleotide by Ionis and Novartis that lowers lipoprotein(a); its phase 3 Lp(a)HORIZON trial missed its MACE endpoint in September 2026.
Pelcitoclax
Pelcitoclax (APG-1252), an investigational Ascentage Pharma BH3 mimetic, dual Bcl-2/Bcl-xL inhibitor designed as a prodrug to reduce platelet toxicity, in trials for SCLC, NSCLC, and other cancers.
Peliosis hepatis
Peliosis hepatis (hepatic peliosis, ICD-11 DB98.1) is a rare benign liver vascular disease with blood-filled cystic sinusoidal cavities, linked to steroids, transplant immunosuppression, and malignancy, diagnosed by biopsy.
Pelizaeus-Merzbacher disease
Pelizaeus-Merzbacher disease (PMD), an X-linked hypomyelinating leukodystrophy caused by PLP1 mutations (duplications, missense, null), causing nystagmus, spasticity, and ataxia; distinct from GJC2-related PMLD1.
Pelizaeus-Merzbacher-like disease
Pelizaeus-Merzbacher-like disease (PMLD, ORPHA:280270) is an autosomal recessive hypomyelinating leukodystrophy mimicking X-linked PMD; main gene GJC2 (connexin 47), also HSPD1, AIMP1, SLC16A2, MAL; onset neonatal or infancy.
Pellagra
Pellagra, from Italian pelle agra, is niacin (vitamin B3) or tryptophan deficiency causing dermatitis, diarrhea, dementia, and death; proven dietary by Goldberger, treatable with nicotinamide.
Pellucid marginal degeneration
Pellucid marginal degeneration, also called pellucid marginal corneal degeneration (PMCD), is a rare, usually bilateral disorder in which a crescent-shaped band of the peripheral cornea thins progressively.
Peloton Interactive
Peloton Interactive is an American fitness company founded in 2012 and headquartered in New York City, selling exercise equipment with subscription workout classes to millions of members.
PELS study
PELS (Post-Cardiotomy Extra-Corporeal Life Support Study, NCT03857217) is a retrospective multicenter cohort study by Maastricht UMC+ of 2,163 adults on ECLS after cardiac surgery, 34 centers, 16 countries, 2000-2020; in-hospital mortality 60.5%, 10-year survival 65.9% among survivors.
Pelubiprofen
Pelubiprofen is a nonsteroidal anti-inflammatory drug of the 2-arylpropionic acid family, related to ibuprofen, developed in South Korea and approved in 2007 for osteoarthritis, later for back pain.
Pelvic arteriovenous malformation
Pelvic arteriovenous malformation (pelvic AVM), a rare congenital high-flow vascular anomaly with internal iliac artery feeders and a dominant outflow vein; treated mainly by coil embolization of the draining vein, with recurrence up to 15%.
Pelvic congestion syndrome
Pelvic congestion syndrome (PCS), now grouped under pelvic venous disorders (PeVD), causes chronic pelvic pain through reflux in ovarian and pelvic veins. Diagnosed by venography and vein diameter criteria; treated with embolization, hormonal therapy, or stenting.
Pelvic examination
Pelvic examination, also called pelvic exam or gynecological examination, is a physical exam of the vulva, vagina, cervix, and uterus using inspection, speculum, and bimanual palpation; recommended for symptoms, disputed as routine screening.
Pelvic examinations under anesthesia by medical students without consent
Pelvic exams under anesthesia (EUA) by medical students without consent: a formerly common teaching practice condemned by ACOG, APGO, and AMA, restricted by 20-plus US state laws, and barred by HHS guidance since April 2024.
Pelvic exenteration
Pelvic exenteration is a major operation removing the bladder, rectum, and reproductive organs, first reported by Alexander Brunschwig in 1948 to treat advanced pelvic cancer.
Pelvic floor dysfunction
Pelvic floor dysfunction: faulty pelvic floor muscle activity (hypertonic, hypotonic, or poorly coordinated) causing incontinence, prolapse, emptying disorders, pain; prevalence ~24-37% of women, 16% of men; physical therapy first line.
Pelvic hernia
Pelvic hernia (ICD-11 DD50.1): hernia through a foramen in the pelvic wall, including obturator, sciatic, perineal, and pudendal hernia; rare, mostly in elderly women, diagnosed by CT and treated surgically.