25,729 articles
ASA physical status classification system
ASA physical status classification system (ASA PS): six-class scale by the American Society of Anesthesiologists rating preoperative fitness from ASA 1 (healthy) to ASA 6 (brain-dead donor), with E emergency modifier, 1941 origin, 2014 revision.
Asanabilvadi Taila
Asanavilvadi Taila (Asanabilvadi Taila, Asana Vilwadi Thailam), an Ayurvedic medicated sesame oil from Sahasrayogam, API Part-II Vol-III; used for eye, ear, and head diseases via nasya, ear drops, and abhyanga.
Asandeutertinib (TY-9591)
Asandeutertinib (TY-9591) is an oral third-generation EGFR tyrosine kinase inhibitor developed by TYK Medicines, conditionally approved in China in 2026 as first-line treatment for EGFR-mutated lung cancer with brain metastases.
Asapiprant
Asapiprant (S-555739, BGE-175) is Shionogi's oral DP1 prostaglandin D2 receptor antagonist (Ki 0.44 nM) developed for allergic rhinitis, reaching phase III in Japan before discontinuation, then licensed to BioAge for a COVID-19 phase 2 trial.
Asbestosis
Asbestosis, also called asbestos pneumoconiosis, is incurable lung fibrosis from inhaled asbestos fibers, appearing 20-30 years after exposure; treated supportively with oxygen, rehabilitation, and vaccinations.
ASC30
ASC30 is Ascletis' investigational small-molecule GLP-1R biased agonist (no beta-arrestin recruitment) for obesity and diabetes, dosed once daily orally and once monthly subcutaneously; Phase II showed 7.7% placebo-adjusted weight loss at 13 weeks.
Ascariasis
Ascariasis, infection by the roundworm Ascaris lumbricoides (also A. suum from pigs), the most common human helminthic infection, affecting 772–892 million people; treated with albendazole, mebendazole, or ivermectin.
ASCEND trial
ASCEND (NCT01366209) was the 2014 phase 3 trial of pirfenidone 2403 mg/day in idiopathic pulmonary fibrosis; it met its FVC primary endpoint and, pooled with CAPACITY, showed 48% lower 1-year mortality.
Ascending aorta
Ascending aorta: first aortic segment from the left ventricle to about T4, ~3.5 cm wide, coronary arteries from its sinuses; aneurysm surgery at 5.0-5.5 cm, Bentall or valve-sparing repair.
Ascending cholangitis
Ascending cholangitis, also called acute cholangitis, is a bacterial infection of the biliary system, typically caused by common bile duct obstruction and potentially leading to sepsis.
ASCENT trial
ASCENT (NCT02574455): global phase 3 trial of sacituzumab govitecan versus physician's-choice chemotherapy in relapsed/refractory metastatic triple-negative breast cancer; 529 patients, median OS 11.8 vs 6.9 months, basis for Trodelvy approval.
Ascher syndrome
Ascher syndrome (Laffer-Ascher syndrome), rare benign disorder combining blepharochalasis, double upper lip, and nontoxic goiter in 10-50% of cases; onset at puberty, OMIM 109900, usually sporadic.
Aschoff body
Aschoff body, also called Aschoff nodule or Aschoff-Talalaev granuloma, is the pathognomonic myocardial granuloma of rheumatic carditis, with fibrinoid necrosis, Aschoff and Anitschkow cells, histiocytic origin, and healing by scarring.
Ascites
Ascites, free fluid in the peritoneal cavity, most often from cirrhosis; also called abdominal dropsy (Greek askos, bag). Diagnosed by SAAG ≥1.1 g/dL; treated with sodium restriction, diuretics, paracentesis, TIPS, or transplant.
ASCORDIA01 trial
ASCORDIA01 (NCT02664597) is a French randomized diagnostic trial, coordinated by Isabelle Thomassin-Naggara, testing whether ADNEX MR score-guided management of sonographically indeterminate adnexal masses reduces inappropriate surgery versus routine care.
Asenapine
Asenapine (Saphris, Sycrest, Secuado) is a tetracyclic atypical antipsychotic given sublingually or transdermally for schizophrenia and bipolar I mania; FDA-approved August 2009, with 35% sublingual bioavailability and less weight gain than olanzapine.
Asepsis
Asepsis: freedom from viable microorganisms and the techniques maintaining it in healthcare. Traces Semmelweis's 1847 handwashing, Lister's 1867 carbolic antisepsis, the 1880s shift to sterile technique, and modern sterilization and disinfection practice.
Aseptic abscess syndrome
Aseptic abscess syndrome (AAS, aseptic abscesses syndrome, ORPHA 54251) is a rare autoinflammatory disorder of recurrent fever and sterile neutrophilic abscesses, mostly splenic, linked to inflammatory bowel disease, treated with corticosteroids, relapsing in over half of patients.
Aseptic myocarditis of newborn
Aseptic myocarditis of newborn (新生儿无菌性心肌炎), ICD-11 1D85.3 under viral carditis, is nonbacterial neonatal heart-muscle inflammation, usually enteroviral (Coxsackie B), with nonspecific symptoms and high neonatal mortality.
Aseptic technique
Aseptic technique is the set of clinical practices that prevents pathogens from entering wounds, catheters, and injection equipment, ranging from medical asepsis to full sterile technique for surgery.
Asfotase alfa
Asfotase alfa (Strensiq, ENB-0040) is a first-in-class bone-targeted recombinant TNSALP enzyme replacement therapy, approved 2015, for perinatal/infantile- and juvenile-onset hypophosphatasia; it improves survival and skeletal mineralization.
ASGPR-mediated GalNAc conjugate uptake
ASGPR-mediated GalNAc conjugate uptake is the delivery mechanism by which GalNAc ligands on oligonucleotide drugs bind the asialoglycoprotein receptor on hepatocytes, enabling receptor-mediated endocytosis of most approved siRNA therapeutics.
Asherman's syndrome
Asherman's syndrome (intrauterine adhesions, synechiae) is uterine scarring after D&C, infection, or tuberculosis, causing amenorrhea, infertility, and pregnancy complications; diagnosed by hysteroscopy, treated by hysteroscopic adhesiolysis.
Ashley T. Haase
Ashley T. Haase is Regents Professor and Head of Microbiology and Immunology at the University of Minnesota, elected to the National Academy of Medicine in 2003, known for methods that visualize HIV infection in intact tissues.
Ashok Seth
Ashok Seth, Indian interventional cardiologist, Chairman of Fortis Escorts Heart Institute, New Delhi; Padma Shri 2003, Padma Bhushan 2015, B.C. Roy Award 2017; 25,000+ angioplasties; pioneer of TAVR and stenting in Asia.
Ashworth Hospital
Ashworth Hospital (Ashworth High Secure Hospital), Maghull, Liverpool: one of three high secure psychiatric hospitals in England and Wales, run by Mersey Care NHS Trust, 13 wards, 210 beds, formed 1989 from Moss Side and Park Lane hospitals.
Asimadoline
Asimadoline (EMD-61753) is an investigational peripherally selective kappa-opioid receptor agonist for IBS-D; potent KOR agonist (IC50 1.2 nM), low CNS penetration, no overall IBS efficacy in trials, subgroup benefit only.
ASK trial (NCT02132494)
ASK (Active Smarter Kids, NCT02132494) was a 7-month Norwegian cluster-randomized trial of 1129 ten-year-olds testing added school physical activity; no overall academic effect, but numeracy gains in the lowest-performing tertile.
Asmarihara kasaya curna
Asmarihara kasaya curna (Aśmarīhara Kaṣāya Cūrṇa) is a classical Ayurvedic kvatha curna (decoction powder) for urinary calculi (asmari, vṛkkaśūla) and dysuria, listed as AFI Part-II 4:3, with SOPs laid down by the Ayurvedic Pharmacopoeia Committee in 2013-14.
ASN001 (timolol maleate gel)
ASN001 (ASN-001), timolol maleate topical gel by Auson Pharmaceuticals for proliferating superficial infantile hemangiomas; US-licensed to Eton Pharmaceuticals (July 2026, $3M upfront), NDA planned 2027; distinct from ophthalmic timolol drops.