25,729 articles
TULSA-PRO
TULSA-PRO is a minimally invasive system by Profound Medical that ablates prostate tissue, including localized prostate cancer, using transurethral directional ultrasound guided by real-time MRI.
Tumaini Rucker Coker
Tumaini Rucker Coker is an American pediatrician and health-equity researcher who chairs Pediatrics at the University of Hawai'i medical school and serves on the U.S. Preventive Services Task Force.
Tumefactive multiple sclerosis
Tumefactive multiple sclerosis (TMS), also called tumefactive demyelinating lesion, is a rare MS variant with demyelinating lesions over 2 cm that mimic brain tumors on MRI.
Tumescent anesthesia
Tumescent anesthesia is a local anesthesia technique injecting large volumes of very dilute lidocaine with epinephrine into fat, developed by Jeffrey Klein in 1987 to permit liposuction without sedation.
Tumid lupus erythematosus
Tumid lupus erythematosus (lupus erythematosus tumidus, LET, ICLE) is a rare, highly photosensitive subtype of cutaneous lupus with smooth edematous plaques, dermal mucin, no scarring, benign course, antimalarial treatment.
Tumor burden score
The tumor burden score (TBS) is a prognostic metric combining maximum tumor diameter and tumor number into one score, proposed in 2016 for colorectal liver metastases.
Tumor grafting
Tumor grafting is a bench biology method that transplants patient tumor tissue into immunodeficient mice, producing patient-derived xenograft (PDX) models that preserve the original cancer's features for drug testing.
Tumor lysis syndrome
Tumor lysis syndrome (TLS), an oncometabolic emergency from rapid cancer cell death causing hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia; defined by Cairo-Bishop criteria, risk-stratified, prevented with hydration, allopurinol, and rasburicase.
Tumor marker
A tumor marker, or tumor biomarker, is a substance made by cancer cells or the body in response to cancer, measured mainly in blood to help diagnose and monitor it.
Tumor Microenvironment
The tumor microenvironment is the ecosystem of immune cells, fibroblasts, blood vessels, and molecules surrounding a tumor that shapes its growth, spread, and resistance to chemotherapy and immunotherapy.
Tumor mutational burden assessment
Tumor mutational burden (TMB), also known as tumor mutation burden, counts somatic mutations per megabase of tumor DNA; in 2020 it supported FDA approval of pembrolizumab for TMB-high solid tumors.
Tumor necrosis factor receptor 1 associated periodic syndrome
TRAPS (familial Hibernian fever) is a rare autosomal dominant autoinflammatory disorder caused by TNFRSF1A mutations, causing recurrent fever episodes lasting 5-25 days with rash, myalgia, and eye inflammation, treatable with IL-1 blockers.
Tumor penetration of nanoparticles
Tumor penetration of nanoparticles is the transport of nanoscale drug carriers from tumor vessels through tissue to reach cancer cells deep within solid tumors, a key obstacle in cancer nanomedicine.
Tumor resection
Tumor resection is a surgical procedure that cuts out a tumor with a margin of healthy tissue and regional lymph nodes, the mainstay of curative cancer treatment.
Tumor Stem Cell Assay
Tumor Stem Cell Assay (tumor clonogenic assay, HTCA): soft-agar technique measuring tumor stem cell colony formation to test anticancer drugs in vitro; predicts resistance (~90%) far better than sensitivity (~57-62%).
Tumor-infiltrating lymphocyte therapy
Tumor-infiltrating lymphocyte (TIL) therapy is an autologous cell therapy for advanced solid cancer in which T cells from a patient's tumor are grown and reinfused.
Tums
Tums is an American antacid brand of chewable calcium carbonate tablets, created in 1928 by pharmacist James Howe, introduced 1930, made in St. Louis, now owned by Haleon, used for heartburn relief.
Tungadrumadi Taila
Tungadrumadi Taila (Tuṅgadrumādi taila), a classical Ayurvedic medicated sesame-oil formulation listed in the Ayurvedic Formulary of India for Śirobhyaṅga; cooling herbs, milk, and coconut water; studied for insomnia and ADHD.
Tungiasis
Tungiasis, or sand flea disease, is a parasitic skin disease caused by the female sand flea Tunga penetrans burrowing into the skin, usually the feet.
Tunlametinib (HL-085)
Tunlametinib (HL-085, Keluping, 妥拉美替尼) is a selective oral MEK1/2 inhibitor from Shanghai KeChow Pharma, conditionally approved in China in March 2024 as the first targeted drug for NRAS-mutant advanced melanoma after anti-PD-1/PD-L1 failure.
Tunnel vision
Tunnel vision, or peripheral vision loss, narrows the visual field to central vision only. Causes include glaucoma, retinitis pigmentosa, retinal detachment, migraine, and low blood pressure; legal blindness is a field of 20 degrees or less.
Tunneling endoscopic resection
Tunneling endoscopic resection, also called submucosal tunneling endoscopic resection, is a minimally invasive endoscopic technique that removes esophageal tumors through a tunnel under the mucosa.
Tuoli Xiaodu San
Tuoli Xiaodu San (托里消毒散), a classic Chinese medicine formula from Chen Shigong's Waike Zhengzong, traces to Xue Ji; 12 herbs, boosts qi and blood, drains pus; used for deficiency-pattern suppurative sores.
TUORA trial
TUORA (NCT06584435, TUOAD-RCC) is a single-arm phase 2 trial of adjuvant toripalimab 240 mg every 3 weeks for 17 cycles after nephrectomy in high-risk renal cell carcinoma, at Tianjin Medical University Second Hospital; interim results showed 100% disease-free survival at 24 months.
Turbinectomy
Turbinectomy is the surgical removal of part or all of the inferior turbinate, a head and neck surgery procedure done to relieve nasal obstruction from turbinate hypertrophy.
Turbinoplasty
Turbinoplasty is a surgical procedure that reduces the nasal turbinates, most often the inferior turbinate, to relieve nasal airway obstruction; it is frequently combined with septoplasty.
Turnpenny-Fry syndrome
Turnpenny-Fry syndrome (TPFS, PCGF2-related disorder, OMIM 618371) is an extremely rare autosomal dominant developmental disorder caused by Pro65 missense variants in PCGF2, causing developmental delay, distinctive facial features, and heart and skeletal abnormalities.
Turoctocog alfa
Turoctocog alfa (NovoEight, Novo Nordisk) is a third-generation B-domain-truncated recombinant factor VIII for hemophilia A, made in CHO cells without plasma, approved 2013, with no confirmed inhibitors in the guardian trials.
Tusamitamab ravtansine
Tusamitamab ravtansine (SAR408701), Sanofi's anti-CEACAM5 antibody-drug conjugate carrying the maytansinoid DM4 (DAR 3.8), was discontinued after phase 3 CARMEN-LC03 missed PFS and OS endpoints versus docetaxel in NSCLC.
Tusi (drug)
Tusi (tusibí, tuci, pink cocaine) is a variable pink powder drug concoction from Colombia, usually ketamine plus MDMA and other drugs, rarely containing cocaine or 2C-B despite its name.