72,234 articles
CM512
CM512 (BEL512) is an IgG1-based bispecific antibody from Keymed Biosciences that blocks both TSLP and IL-13; the first IgG-like long-acting TSLP×IL-13 dual blocker, half-life about 59-74 days, licensed outside Greater China to Belenos, in phase 3 for CRSwNP.
CM536
CM536 (BEL536) is Keymed Biosciences' OX40L x IL-13 bispecific antibody for immune-mediated inflammatory diseases, licensed ex-Greater China to OrbiMed-backed Belenos Biosciences in July 2024 for US$15 million upfront plus milestones; atopic dermatitis is its lead indication.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
CMAJ (Canadian Medical Association Journal; Journal de l'Association médicale canadienne) is Canada's peer-reviewed general medical journal, founded January 1911 under Sir Andrew Macphail, open access since 2020, 2024 impact factor 12.2.
CME W1 cl.8+
CME W1 cl.8+ (Clone 8, Cl.8, CVCL_Z790) is a spontaneously immortalized Drosophila melanogaster cell line cloned from CME W1, derived from male third instar wing imaginal disc, ecdysone-susceptible, a modENCODE core line, DGRC stock 151.
CMG1A46
CMG1A46 (1A46) is Chimagen Biosciences' IgG-like CD19/CD20/CD3 trispecific T-cell engager on the TRIAD platform, acquired by GSK in 2024 for $300 million upfront, in trials for B-cell lymphoma, leukemia, and lupus.
CMG901 (Claudin 18.2 ADC)
CMG901, also known as AZD0901 or sonesitatug vedotin, is an antibody–drug conjugate targeting Claudin 18.2, discovered by Keymed Biosciences and licensed to AstraZeneca for gastric, gastroesophageal junction, and pancreatic cancers.
CML treatment beyond TKIs
CML treatment beyond TKIs covers the options when targeted drugs fail or stop: allogeneic stem-cell transplantation, donor lymphocyte infusion, interferon and hydroxyurea, and treatment-free remission.
CMSI&Child trial
CMSI&Child (NCT06016296) is a Chilean randomized controlled trial testing a 12-week combined movement and storytelling intervention on motor skills, language, and physical activity in 144 children aged 3 to 6.
CMT-VX trial
CMT-VX (NCT07665424) is a Taiwanese randomized non-inferiority trial testing the CMT Vessel-X PET bone-filling container against conventional vertebroplasty in 146 patients aged 40-95 with osteoporotic vertebral compression fractures, primary endpoint unanticipated serious adverse device effects.
CMT12
CMT12 (CMT-12, CVCL_L329) is a canine mammary carcinoma cell line derived from a Poodle papillary adenocarcinoma, formerly named CMT-2, with homozygous KMT2C and TP53 mutations, constitutive COX-2 overexpression, and FACC panel membership.
CN201 (MK-1045)
CN201 (CN-201, MK-1045) is a humanized CD19xCD3 bispecific IgG4 T-cell engager developed by Curon Biopharmaceutical and acquired by Merck in 2024 for $700 million upfront, in trials for B-cell lymphoma, ALL, and autoimmune disease.
Cnemaspis
Cnemaspis (rock geckos, day geckos, dwarf geckos) is a speciose gecko genus, Gekkonidae, type species C. boulengeri, 232 species from South Asia and the Malay Archipelago; African species moved to Ancylodactylus.
Cnidaria
Cnidaria, also called Coelenterata by some authors, is the animal phylum of corals, jellyfish, sea anemones, hydrozoans, and myxozoan parasites, defined by cnidae (nematocysts), diploblastic radial bodies, polyp and medusa forms, and over 10,000 aquatic species.
Cnidarian feeding and digestion
Cnidarian feeding and digestion: how corals, anemones, and jellyfish capture prey with nematocysts and digest it extracellularly in the gastrovascular cavity, then intracellularly in gastrodermal cells, via an incomplete digestive system.
Cnidarian nervous, sensory and muscular systems
Cnidarian nervous, sensory and muscular systems: how jellyfish, anemones, and Hydra coordinate without a brain, using diffuse nerve nets, nerve rings, rhopalia with eyes, bidirectional synapses, and epitheliomuscular muscle sheets.
Cnidarians of the Atlantic Ocean
Cnidarians of the Atlantic Ocean are the jellyfish, hydroids, siphonophores, corals, and sea anemones whose distributions span the Atlantic basin, with 2,188 species in the North Atlantic and 932 in the South.
Cnidarians of the Indian Ocean
The cnidarians of the Indian Ocean are its jellyfish, hydroids, sea anemones, and corals, about 2,587 species, with coral diversity peaking in the northern Mozambique Channel.
Cnidarians of the Pacific Ocean
Cnidarians of the Pacific Ocean are the jellyfish, corals, sea anemones, and hydroids spanning the basin, with about 3,111 species in the North Pacific and the richest fauna in the Coral Triangle.
Cnidocyte
Cnidocyte (nematocyte, cnidoblast): the explosive stinging cell defining phylum Cnidaria; contains a cnidocyst organelle that fires a venomous tubule in as little as 700 ns at up to 5,400,000 g.
Cnidoscolus
Cnidoscolus (spurge nettle, chaya) is an American Euphorbiaceae genus of about 93–99 stinging-haired species centered in Mexico and Brazil, used in folk medicine and as the leafy vegetable chaya, which must be boiled to remove cyanogenic glycosides.
CNN2 study
The CNN2 study is a clinical trial at Mỹ Đức Hospital in Ho Chi Minh City, Vietnam, testing whether a blood test for calponin 2 can identify tubal pregnancies.
CNR1
CNR1 (HGNC:2159, Gene ID 1268) is the human chromosome 6q15 gene encoding cannabinoid receptor 1 (CB1), a Gi/o-coupled GPCR of 472 amino acids activated by THC and endocannabinoids; cloned in 1990, structure solved 2016.
CNTNAP2
CNTNAP2 (contactin associated protein 2, CASPR2) is a ~2.3 Mb gene at 7q35 encoding a neurexin-family cell-adhesion protein; biallelic variants cause a recessive epilepsy-intellectual disability disorder (Definitive), while its autosomal dominant autism link is Disputed.
CNTNAP2-related developmental and epileptic encephalopathy
CNTNAP2-related developmental and epileptic encephalopathy (CASPR2-deficiency disorder; formerly Pitt-Hopkins-like syndrome-1, OMIM 610042) is a rare autosomal recessive disorder with intellectual disability, speech impairment, and early-onset epilepsy with regression.
CNTRACS trial
CNTRACS (Cognitive Neuroscience Test Reliability and Clinical Applications for Schizophrenia Consortium) is a five-site NIMH program, not a drug trial, validating cognitive neuroscience tasks (DPX, RISE, CCE, JOVI) as clinical trial measures in schizophrenia, now extended computationally (NCT07853807).
Co-115
Co-115 (CVCL_D102, RRID:CVCL_D102) is a human colon adenocarcinoma cell line established in 1976 from a nude-mouse xenograft of a 77-year-old woman's ascending colon tumor; MSI, BRAF V600E, PTEN mutations, CMS1 subtype.
Co-chaperone
Co-chaperone: non-client proteins binding Hsp70 or Hsp90 (Hop/Sti1, Cdc37, Aha1, p23, immunophilins) that regulate chaperone ATPase cycles, recruit clients, and link chaperone systems; about fifty exist in human cells.
Co-culture (cell biology)
Co-culture, or cell co-culture, is a laboratory method that grows two or more cell types together in one vessel so their signaling interactions can be studied directly.
CO-detection by indexing
CO-detection by indexing (CODEX) is a highly multiplexed fluorescence imaging method that maps dozens of proteins in tissue sections by staining DNA-barcoded antibodies all at once and imaging them in iterative cycles.
Co-fermentation
Co-fermentation is a fermentation strategy in which two or more substrates or microbial strains are fermented simultaneously, raising yield beyond single-substrate fermentation, notably for cellulosic ethanol.