Life and health

Delafloxacin

Delafloxacin (Baxdela, ABT-492, RX-3341) is an anionic fluoroquinolone antibiotic approved by the FDA in June 2017 for acute bacterial skin and skin structure infections, non-inferior to vancomycin plus aztreonam, with IV and oral formulations.

Delamanid

Delamanid (Deltyba), Otsuka's nitroimidazole antibiotic for multidrug-resistant tuberculosis; EMA-authorized 2014, WHO Group C medicine, QT-prolonging, now in the 6-month BDLLfxC regimen.

Sep 21, 2026

Delan Devakumar

Delan Devakumar is a British public health physician and Professor of Global Child Health at UCL, known for work on racism, migration, and child health.

Delandistrogene moxeparvovec

Delandistrogene moxeparvovec (Elevidys, delandistrogene moxeparvovec-rokl) is Sarepta's one-time AAVrh74 gene therapy delivering micro-dystrophin for Duchenne muscular dystrophy; first US-approved DMD gene therapy (2023), later given a boxed liver-failure warning and ambulatory-only indication (2025).

Delapril

Delapril (地拉普利) is a lipophilic nonsulfhydryl ACE inhibitor prodrug launched by Takeda in 1989 for hypertension, converted to two active diacid metabolites and marketed in fixed combinations with manidipine and indapamide.

Delavirdine

Delavirdine (DLV, Rescriptor) is a bisheteroarylpiperazine NNRTI for HIV-1, approved by the FDA on April 4, 1997 as the second NNRTI after nevirapine; dosed 400 mg three times daily, limited by rash and rapid K103N resistance, now discontinued.

Delayed and special-system mushroom poisoning syndromes

Delayed and special-system mushroom poisoning syndromes are rare poisonings that begin a day or more after ingestion, causing muscle breakdown, burning extremities, or brain injury.

Sep 29, 2026

Delayed breast reconstruction

Delayed breast reconstruction is a surgical procedure that rebuilds the breast in a second operation, weeks to years after mastectomy, usually once cancer treatment is finished.

Delayed Diagnosis

Delayed diagnosis (late diagnosis, diagnosis delay): a diagnosis established later than optimal, one of three diagnostic error types; affects about 5% of US outpatients yearly, driven by test-ordering and follow-up failures.

Delayed ejaculation

Delayed ejaculation, also known as retarded ejaculation, is a male sexual dysfunction in which a man needs an unusually long time to ejaculate, or cannot at all.

Delayed encephalopathy due to carbon monoxide poisoning

Delayed encephalopathy due to carbon monoxide poisoning, also called delayed neuropsychiatric sequelae, is a rare neurological disorder that emerges weeks after apparent recovery from carbon monoxide poisoning, causing cognitive impairment, personality changes, and parkinsonism.

Delayed onset muscle soreness

Delayed onset muscle soreness (DOMS), or muscle fever, is pain and stiffness peaking 24–72 hours after unaccustomed eccentric exercise, caused by ultrastructural muscle damage, inflammation, and nociceptor sensitization; massage, compression, and immersion help, stretching does not.

Delayed pressure urticaria

Delayed pressure urticaria (DPU), also called pressure urticaria, is a rare chronic inducible urticaria (ICD-11 EB01.2) in which sustained pressure causes painful deep swellings after 4-6 hours, lasting up to 3 days; antihistamines are first-line, omalizumab for resistant cases.

Delayed puberty

Delayed puberty: absence of pubertal signs 2–2.5 SD later than population mean (age 13 girls, 14 boys). Most cases are constitutional delay of growth and puberty, a benign self-limited variant; main alternative is hypogonadism.

Delayed separation of umbilical cord

Delayed separation of umbilical cord, ICD-11 KC20.0, is failure of the stump to detach beyond 3 weeks; up to 10% of newborns, usually benign, but a first sign of leukocyte adhesion deficiency when paired with omphalitis, absent pus, and leukocytosis.

Delayed sleep-wake phase disorder

Delayed sleep-wake phase disorder (DSWPD, formerly DSPS/DSPD), ICD-11 7A60: a circadian rhythm sleep-wake disorder with persistently delayed sleep timing; normal sleep on a delayed schedule; affects about 1% of adults, 3.3-4.6% of adolescents; treated with timed melatonin and light therapy.

Delayed union of fracture

Delayed union of fracture (ICD-11 FB80.9): a fracture not united within the expected consolidation time but still healing slowly, between normal union and nonunion; risk factors include smoking, diabetes, and unstable fixation.

Delayed-Action Preparations

Delayed-Action Preparations (MeSH D003692), also called extended-, sustained-, controlled-, or depot-release formulations, are drug dosage forms acting over time via controlled-release technology, used to lengthen dosing intervals and smooth serum drug levels.

Delbert A. Fisher

Delbert A. Fisher (1928–2026) was an American pediatric endocrinologist, elected to the National Academy of Medicine in 1988, whose work launched newborn screening for congenital hypothyroidism.

Deleobuvir

Deleobuvir (BI 207127) is an oral nonnucleoside inhibitor of HCV NS5B RNA polymerase binding thumb-pocket 1. It reached phase 3 HCVerso trials with faldaprevir and ribavirin before Boehringer Ingelheim discontinued development.

Deleted in esophageal cancer 1

DELEC1 (deleted in esophageal cancer 1, formerly DEC1, alias CTS9) is a human long non-coding RNA gene at 9q33.1, a candidate tumor suppressor with reduced expression in esophageal squamous cell carcinoma; distinct from DLEC1 at 3p22.3.

Deletion 5q35 syndrome

Deletion 5q35 syndrome, also called distal 5q deletion or monosomy 5q35, is a rare chromosomal disorder from terminal deletions of 5q35.1-q35.3; NSD1 deletion causes Sotos syndrome, larger deletions add NKX2.5-related heart defects.

Sep 29, 2026

Deletion mapping

Deletion mapping is a genetic technique that localizes a gene or mutation to a chromosomal interval by testing it against a panel of strains carrying defined chromosomal deletions.

Deletions of chromosome 1

Deletions of chromosome 1 (del(1p), del(1q), 1p36 deletion syndrome, 1q21.1 microdeletion): losses of genetic material from the largest human chromosome, causing constitutional syndromes such as 1p36 deletion and somatic lesions in neuroblastoma, glioma, and myeloma.

Deletions of chromosome 10

Deletions of chromosome 10, or partial monosomy 10, are rare chromosomal disorders missing part of 10p or 10q; 10q26 deletion syndrome (OMIM 609625) involves 3.5–17 Mb deletions with developmental delay, craniofacial anomalies, and heart defects.

Deletions of chromosome 11

Deletions of chromosome 11 (ICD-11 LD44.B; partial monosomy 11) are losses of genetic material from chromosome 11's long or short arm, causing syndromes such as Jacobsen (11q terminal deletion, 1/100,000 newborns), WAGR (11p13), and Potocki-Shaffer (11p11.2).

Deletions of chromosome 13

Deletions of chromosome 13 (13q deletion syndrome, distal monosomy 13q, ICD-11 LD44.D): constitutional partial monosomy 13q causing intellectual disability, microcephaly, and malformations, plus somatic 13q14 deletions in CLL and myeloma.

Deletions of chromosome 14

Deletions of chromosome 14, also called partial monosomy 14 (ICD-11 LD44.E), are missing segments of chromosome 14, mostly the q arm, spanning proximal 14q11.2/14q12, medial 14q22q23, and distal 14q32 forms, causing developmental delay, hypotonia, microcephaly, and FOXG1 or Temple syndromes depending on region.

Deletions of chromosome 15

Deletions of chromosome 15: segmental losses causing Prader-Willi (paternal 15q11-q13), Angelman (maternal), and microdeletion syndromes at 15q11.2, 15q13.3, 15q24, and 15q26 with variable neurodevelopmental effects.