72,234 articles
EBF1
EBF1 (EBF transcription factor 1; also EBF, O/E-1, COE1, OLF1), human gene at 5q33.3, encodes a pioneer transcription factor that specifies B cell fate with E2A and Pax5, binds 5′-TCCCNNGGGA via a zinc knuckle, and is linked to B-ALL leukemia.
eBird
eBird is a participatory-science bird monitoring program run by the Cornell Lab of Ornithology since 2002, in which birdwatchers submit checklists feeding a database used by researchers.
Ebola
Ebola disease, a severe often fatal hemorrhagic illness caused by orthoebolaviruses (Ebola, Sudan, Bundibugyo viruses), first identified 1976 near the Ebola River; ~50% case fatality, treatments and vaccines only for the Zaire species.
Ebola in Uganda
Ebola in Uganda refers to the recurring Ebola virus disease outbreaks Uganda has experienced since the first confirmed episode in Gulu District in 2000, caused successively by Sudan, Bundibugyo, and Zaire ebolaviruses.
Ebola vaccine
Ebola vaccine: vaccines against orthoebolaviruses, chiefly Ervebo (rVSVΔG-ZEBOV-GP, Merck), the only licensed, WHO-prequalified Ebola vaccine (EMA/FDA 2019), used in ring vaccination; no licensed vaccine for Bundibugyo or Sudan virus disease.
Ebola virus cases in the United States
Ebola virus cases in the United States: 11 patients treated in 2014–2016, including Thomas Eric Duncan and the first domestically acquired cases (nurses Nina Pham and Amber Vinson) in Dallas, plus aid worker Craig Spencer in New York.
Ebolavirus
Ebolavirus (Orthoebolavirus), filovirus genus causing Ebola disease; six species, three causing large outbreaks (Ebola, Sudan, Bundibugyo viruses). Discovered 1976 near the Ebola River, DRC; fatality 25–90%; vaccines only for Ebola virus disease.
EBOVAC3DRC trial
EBOVAC3DRC (EBL2007, NCT04186000) is an open-label Phase 2 trial of the two-dose Ad26.ZEBOV plus MVA-BN-Filo Ebola vaccine regimen, with optional Ad26 boosters, in health care providers in Boende, DRC, under the EBOVAC3/IMI2 project.
Ebrahim M. Samba
Ebrahim Malick Samba (1928–2016) was a Gambian physician who led the WHO river blindness program in West Africa and was WHO Regional Director for Africa from 1995 to 2005.
Ebronucimab (AK102)
Ebronucimab (伊努西单抗, AK102, brand 伊喜宁) is a fully human IgG1 anti-PCSK9 monoclonal antibody by Akeso/AD Pharmaceuticals, approved in China on 26 September 2024 for primary hypercholesterolemia and mixed dyslipidemia, dosed 150 mg Q2W or 450 mg Q4W.
Ebrotidine
Ebrotidine (FI-3542, CAS 100981-43-9) is an H2-receptor antagonist antiulcer drug with added cytoprotective and anti-Helicobacter pylori activity, tested in phase II and III trials against ranitidine for peptic ulcer.
Ebstein's anomaly
Ebstein malformation of the tricuspid valve (Ebstein anomaly), a rare congenital heart defect with apically displaced tricuspid leaflets and atrialized right ventricle; described by Wilhelm Ebstein in 1866, treated by cone repair.
EC regimen (chemotherapy)
The EC regimen is a two-drug chemotherapy combination of epirubicin and cyclophosphamide, used mainly as neoadjuvant or adjuvant treatment for breast cancer over 3 to 6 cycles.
EC50
EC50 (half maximal effective concentration) is the agonist concentration producing a response halfway between baseline and maximum; the standard potency measure in pharmacology, derived from the 1910 Hill equation, distinct from IC50 and Kd.
ECA stack
ECA stack: ephedrine, caffeine, and aspirin combination promoted for weight loss and athletic performance. Modest short-term fat loss (~2 lb/month with ephedrine plus caffeine), 2-3x side-effect risk; ephedra supplements banned by FDA in 2004.
Ecabet
Ecabet is a diterpenoid anti-ulcer drug, marketed in Japan as ecabet sodium, taken orally for gastric ulcers and gastritis and studied for eliminating H. pylori.
Ecallantide
Ecallantide (Kalbitor, DX-88) is a recombinant 60-amino-acid plasma kallikrein inhibitor (Ki 25 pM) injected subcutaneously, 30 mg, for acute hereditary angioedema attacks; US-only approval (2009), boxed warning for anaphylaxis (4%).
Ecarin clotting time
The ecarin clotting time (ECT) is a coagulation assay using ecarin, venom of the saw-scaled viper, to measure direct thrombin inhibitors such as dabigatran and hirudin.
ECC4703
ECC4703 (ECC-4703) is Eccogene's oral, liver-targeting THR-β full agonist in Phase IIa trials for MASH (MOSAIC, with ECC0509) and as a semaglutide adjunct for obesity (MIST); IND approved 2022.
ECC5004 / AZD5004 (oral GLP-1 receptor agonist)
ECC5004/AZD5004 (elecoglipron) is an oral, once-daily small-molecule GLP-1 receptor agonist discovered by Eccogene and licensed to AstraZeneca in 2023 for $185 million upfront, in Phase 3 development for type 2 diabetes and obesity.
Eccentric training
Eccentric training is a resistance training method in which muscles actively lengthen under load, building strength and muscle and rehabilitating tendon injuries such as Achilles tendinopathy.
Eccentric viewing
Eccentric viewing, also called eccentric fixation, is a low vision rehabilitation technique in which people with central vision loss learn to use undamaged paracentral retina instead of the fovea.
Eccrine angiomatous hamartoma
Eccrine angiomatous hamartoma (EAH), or eccrine angiomatous nevus, is a rare benign skin hamartoma of eccrine glands and capillary channels, usually on children's limbs, causing pain and localized sweating; excision is usually curative.
Ecd family
Ecd family (InterPro IPR010770, Pfam PF07093 SGT1): conserved eukaryotic proteins named for Drosophila ecdysoneless. Human member ECD/SGT1 (644 aa) regulates p53, Rb cell cycle control, pre-mRNA splicing, and ER stress.
Ecdysis
Ecdysis, also called moulting, is the shedding of the cuticle in Ecdysozoa such as arthropods and nematodes. Controlled by ecdysteroids from the Y-organ, MIH, ETH, EH, CCAP, and bursicon, it enables growth but leaves the animal vulnerable.
Ecdysozoa
Ecdysozoa is a clade of protostome animals defined by molting, or ecdysis, that includes arthropods, nematodes, tardigrades, and related phyla, with over a million described species.
Ecdysteroid receptor
Ecdysteroid receptor (EcR): invertebrate nuclear receptor binding 20-hydroxyecdysone, functioning as an EcR-USP heterodimer, cloned 1991 in Drosophila, target of dibenzoylhydrazine insecticides and gene-switch systems.
ECE1
ECE1 (endothelin converting enzyme 1, ECE-1, EC 3.4.24.71) is a human M13 zinc metalloendopeptidase gene on 1p36.12 that converts big endothelin-1 to vasoactive ET-1, with four isoforms, broad peptide substrate specificity, and mutations linked to Hirschsprung disease.
Echeveria
Echeveria DC., also known as Mexican rosettes or Mexican snowballs, is a Crassulaceae succulent genus of about 219 accepted species native from southern Texas to northwestern Argentina, centered in Mexico, with CAM photosynthesis and rosette growth.
Echidna
Echidnas, also known as spiny anteaters, are egg-laying mammals of Australia and New Guinea, covered in spines and eating ants and termites with a long sticky tongue.