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Life and health

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Flumatinib

Flumatinib (HH-GV-678, Hansoh Xinfu, 豪森昕福) is a second-generation BCR-ABL tyrosine kinase inhibitor approved in China (2019) for newly diagnosed chronic-phase CML; FESTnd showed superior molecular responses to imatinib.

Flumazenil

Flumazenil (Ro 15-1788, Anexate) is an imidazobenzodiazepine competitive antagonist at the benzodiazepine receptor, made by Roche (1979, marketed 1987), used to reverse benzodiazepine and Z-drug sedation but not barbiturates, ethanol, or opioids.

Flumequine

Flumequine is a synthetic quinolone antibacterial, first described 1976, the first C-6 fluorinated quinolone; withdrawn from human use for ocular toxicity, still a veterinary drug for livestock and farmed fish, selecting the same GyrA resistance as fluoroquinolones.

Flumetralin

Flumetralin (CAS 62924-70-3), a 2,6-dinitroaniline plant growth regulator that inhibits microtubules, used as a tobacco suckercide; US-registered since 1983, EU approval withdrawn after industry pulled renewal in 2024.

Flumetsulam

Flumetsulam (DE 498) is a triazolopyrimidine sulfonanilide ALS-inhibiting herbicide introduced by DowElanco in 1994 for broadleaf weed control in maize, soybeans, and pasture; not EU-approved, low mammalian toxicity.

Flumexadol

Flumexadol (CERM-1841), 2-[3-(trifluoromethyl)phenyl]morpholine, CAS 30914-89-7, is a trifluoromethylphenyl morpholine, non-narcotic analgesic, and selective 5-HT2C receptor agonist (Ki 25 nM, (+)-enantiomer); active metabolite of oxaflozane, listed as withdrawn.

Flumiclorac pentyl

Flumiclorac pentyl (Resource, Sumiverde; CAS 87546-18-7) is a Sumitomo-developed Group 14 PPO-inhibiting, N-phenylphthalimide post-emergence herbicide for broadleaf weeds in soybeans, corn, and cotton defoliation; hydrolyzes rapidly, EU not approved.

Fluminense

Fluminense (FEOW ecoregion 352), a freshwater ecoregion of coastal Rio de Janeiro state, Brazil, between the Paraíba do Sul and Restinga da Marambaia; tropical coastal rivers with 42% endemic fish, distinct from the Fluminense Football Club.

Flumioxazin

Flumioxazin (CAS 103361-09-7), a Sumitomo N-phenylphthalimide PPO-inhibiting pre- and post-emergence herbicide for broadleaf and grass weeds; EU approval renewed to 2037, classified Repro 1B and Aquatic Acute 1.

Flunarizine

Flunarizine, a selective calcium-entry blocker related to cinnarizine, is a once-daily 5–10 mg migraine prophylactic with level A evidence, also used for vertigo and refractory epilepsy; not marketed in the US, limited by somnolence, weight gain, depression, and parkinsonism.

Flunisolide

Flunisolide (AeroBid, Nasalide, Nasarel) is a synthetic corticosteroid, glucocorticoid receptor agonist, C24H31FO6, half-life 1.8 h, used as nasal spray for allergic rhinitis and inhaler for asthma; first FDA-approved INCS spray (1981).

Flunitrazepam

Flunitrazepam (Rohypnol, roofies) is a Roche benzodiazepine hypnotic from 1975 used for insomnia and anesthesia, known for amnesia, abuse, date-rape association, and fatal intoxications; illegal in the US, Class C in the UK.

Fluocinonide

Fluocinonide, a synthetic topical corticosteroid (21-acetate ester of fluocinolone acetonide, C26H32F2O7, US approval 1971), treats eczema and psoriasis as 0.05% and super-high-potency 0.1% creams, gels, and ointments.

Fluocortolone

Fluocortolone (Ultralan) is a synthetic fluorinated glucocorticoid used topically for skin disorders; its pivalate and hexanoate esters appear in rectal products Ultraproct and Doloproct for haemorrhoids, fissures, and proctitis.

Fluometuron

Fluometuron (Cotoran), a phenylurea herbicide, CAS 2164-17-2, introduced 1960 by Ciba-Geigy; photosystem II inhibitor used mainly on cotton; soil half-life 12–171 days; US-registered 1974, EU-approved 2011.

Fluopicolide

Fluopicolide, a pyridinylmethyl-benzamide (FRAC Group 43) anti-oomycete fungicide launched by Bayer in 2006, targets vacuolar H+-ATPase and controls Phytophthora, Plasmopara, Pythium, Peronospora, and Bremia.

Fluopyram

Fluopyram (CAS 658066-35-4) is a Bayer CropScience SDHI fungicide, also used as a nematicide against root-knot nematodes; EU-approved 2014, ADI 0.012 mg/kg bw, ARfD 0.5 mg/kg bw.

Fluorescein

Fluorescein (uranine, fluorescein sodium) is a xanthene dye, C20H12O5, synthesized by Adolf von Baeyer in 1871, absorbing near 490 nm and emitting green fluorescence; used in ophthalmic angiography, FITC antibody labeling, pH probes, and water tracing.

Fluorescein lisicol

Fluorescein lisicol (NRL972, cholyl-lysyl-fluorescein) is a fluorescent bile acid analog developed by Norgine as an investigational marker of hepatic biliary transporter function; development was discontinued in July 2013.

Fluorescence in situ hybridization

Fluorescence in situ hybridization (FISH) is a cytogenetic technique using fluorescent DNA probes to detect chromosomes or gene regions in cells, applied in cancer diagnostics, prenatal testing, and radiation biodosimetry.

Fluorescence labeling

Fluorescence labeling is a bench biology technique that attaches fluorescent dyes or proteins to biomolecules or cells, letting researchers visualize their presence, localization, and abundance.

Fluorescence laser scanning microscopy

Fluorescence laser scanning microscopy, also called laser scanning fluorescence microscopy, is an optical microscopy method that builds images pixel by pixel with a scanned laser.

Fluorescence lifetime imaging microscopy

Fluorescence lifetime imaging microscopy (FLIM) maps the decay time of fluorescence from every pixel of labeled cells or tissue, enabling FRET measurements, metabolic imaging, and clinical tissue sensing.

Fluorescence loss in photobleaching

Fluorescence loss in photobleaching (FLIP) is a live-cell microscopy technique in which a small region is bleached repeatedly with a laser, revealing how proteins diffuse and move between cellular compartments.

Fluorescence Microscopy

Fluorescence microscopy images fluorophore-labeled specimens by detecting longer-wavelength emitted light; spans widefield, confocal, TIRF, two-photon, light sheet, and super-resolution modalities with distinct resolution, depth, and speed trade-offs.

Fluorescence molecular tomography

Fluorescence molecular tomography, also called fluorescence tomography, is an optical imaging method that reconstructs 3D distributions of fluorescent probes inside living tissue from surface measurements.

Fluorescence polarization immunoassay

A fluorescence polarization immunoassay (FPIA) is a homogeneous competitive immunoassay that quantifies small analytes like drugs and hormones in minutes, used in therapeutic drug monitoring and food testing.

Fluorescence polarization microscopy

Fluorescence polarization microscopy is a fluorescence technique that measures emission polarization pixel by pixel to map the orientation, clustering, and rotational mobility of labeled biomolecules in cells.

Fluorescence speckle microscopy

Fluorescence speckle microscopy, also known as fluorescent speckle microscopy, is a live-cell imaging technique that measures assembly, movement, and turnover of cytoskeletal filaments by imaging a small fraction of fluorescently labeled subunits as speckles.

Fluorescence staining

Fluorescence staining attaches fluorescent dyes to specific structures or biomolecules in cells and tissues so they can be visualized under a fluorescence microscope, most often through immunofluorescence.