400 articles
MDA-MB-435
MDA-MB-435 is a human cancer cell line established in 1976 as a breast carcinoma line, later shown by genetic testing to be a melanoma line derived from M14.
MDA-MB-435S
MDA-MB-435S (CVCL_0622, ATCC HTB-129), also called MDA-MB-435s or BrCL15, is a human cancer cell line long used as a breast cancer model but shown by STR authentication to be a misidentified derivative of the M14 melanoma line, carrying BRAF V600E.
MDA-MB-436
MDA-MB-436 (MD Anderson-Metastatic Breast-436, CVCL_0623, ATCC HTB-130) is a triple-negative, BRCA1-mutant (c.5277+1G>A) human breast cancer cell line from a 1978 pleural effusion metastasis, used as a Basal B/mesenchymal TNBC and chemoresistance model.
MDA-MB-453
MDA-MB-453 (CVCL_0418, ATCC HTB-131) is a human breast cancer cell line established in 1976 from a pericardial effusion, ER−/PR−, androgen receptor-positive and HER2-positive, used for androgen receptor and HER2 research.
MDA-MB-468
MDA-MB-468 (ATCC HTB-132, CVCL_0419) is a human triple-negative, basal-like breast cancer cell line isolated in 1977 from a pleural effusion of a 51-year-old Black female donor, carrying TP53 R273H, PTEN loss, and amplified EGFR.
MDBK
MDBK (Madin-Darby Bovine Kidney, NBL-1, ATCC CCL-22) is a bovine kidney epithelial cell line established in 1957 by Madin and Darby, widely used for propagating bovine viruses and as a transfection host.
MDCK
MDCK, short for Madin-Darby Canine Kidney, is a dog kidney cell line established in 1958 that is the standard model for epithelial polarity and a substrate for influenza vaccines.
ME-180
ME-180 (ME180, ATCC HTB-33, CVCL_1401) is a human cervical epidermoid carcinoma cell line from a 66-year-old woman, HPV-positive (HPV68/39 reports), p53+/pRB+, PIK3CA-mutant, widely used in cervical cancer drug research.
MEG-01
MEG-01 (CVCL_0425, ATCC CRL-2021) is a human megakaryoblastic leukemia cell line derived in 1983 from the bone marrow of a 55-year-old man with Philadelphia chromosome-positive CML in blast crisis, distinguished by uniform surface GP IIb/IIIa and spontaneous platelet-like particle release.
MES-SA
MES-SA (ATCC CRL-1976, Cellosaurus CVCL_1404) is a human uterine sarcoma cell line established in 1980 from a 56-year-old woman, drug-sensitive, MDR1-negative, and the parent of the P-glycoprotein-overexpressing multidrug-resistant MES-SA/Dx5 model.
MeT-5A
MeT-5A (MeT5A, CVCL_3749, ATCC CRL-9444) is an SV40 large T antigen-immortalized, non-tumorigenic human pleural mesothelial cell line from non-cancerous donors, established in 1989 and widely used in asbestos and fiber toxicology research.
MG-63
MG-63 (MG63, CVCL_0426) is a human osteosarcoma cell line from a 14-year-old male, left femur, reported 1977 as an interferon producer; an osteoblast-like model that does not mineralize.
MGAR
MGAR (CVCL_E775, ECACC 88022014) is an EBV-transformed human B-lymphoblastoid cell line from a Hispanic female donor, part of the 10th International Histocompatibility Workshop panel, HLA-typed A*26:01, B*08:01, C*07:01, DRB1*15:01.
MIA PaCa-2
MIA PaCa-2 (MiaPaCa-2, CVCL_0428, ATCC CRL-1420) is a human pancreatic undifferentiated carcinoma cell line established in 1975 from a 65-year-old man, carrying KRAS G12C, TP53 R248W, and CDKN2A deletion.
Microfluidic cell culture
Microfluidic cell culture is a bench technique that grows cells in microscale channels, controlling perfusion, chemical gradients, and mechanical forces beyond what Petri dishes and well plates can.
Microfluidic model
A microfluidic model is a bench biology method in which miniature tissues are cultured in microfluidic chips whose channels, flow, and gradients control the cells' microenvironment, best known as the organ-on-a-chip.
MKN1
MKN1 (MKN-1, CVCL_1415) is a human gastric adenosquamous carcinoma cell line established in 1977 from a lymph node metastasis of a 72-year-old Japanese man, carrying a TP53 Val143Ala mutation, E-cadherin promoter hypermethylation, and MSS status.
MKN28
MKN28 (MKN-28, CVCL_1416) is a human gastric tubular adenocarcinoma cell line from a Japanese male's liver metastasis, used as a well-differentiated, EGFR-high, MSS gastric cancer model, but shown to be an MKN74 derivative and listed by ICLAC as misidentified.
MKN45
MKN45 (MKN-45, CVCL_0434) is a human diffuse-type gastric adenocarcinoma cell line from a liver metastasis in a 62-year-old Japanese woman, MET-amplified, microsatellite stable, adherent, and widely used in gastric cancer research.
MKN74
MKN74 (MKN-74, CVCL_2791) is a human gastric tubular adenocarcinoma cell line from a liver metastasis in a 37-year-old Japanese male, intestinal-type, wild-type or mutant p53 reports, doubling time about 44 hours.
MM200
MM200 (CVCL_C836) is a human primary melanoma cell line from a 43-year-old female skin donor, carrying BRAF V600E and PTEN mutations, wild-type p53, and used widely in melanoma apoptosis, drug resistance, and immunotherapy research.
MNNG/HOS Cl #5
MNNG/HOS Cl #5 (CVCL_0439, ATCC CRL-1547), also called MNNG-HOS or HOS-MNNG, is a human osteosarcoma cell line made by MNNG chemical transformation of HOS-TE85; where the MET oncogene was first identified.
MOLM-13
MOLM-13 (CVCL_2119, RRID:CVCL_2119) is a human acute myeloid leukemia cell line from a 20-year-old man's peripheral blood, carrying KMT2A-MLLT3 (MLL-AF9) fusion and heterozygous FLT3-ITD; a standard model for FLT3 inhibitor and drug-resistance research, distinct from its same-patient sibling MOLM-14.
MOLT-3
MOLT-3 (Molt 3, CVCL_0624) is a human T lymphoblast leukemia cell line established in 1971 from a 19-year-old male ALL patient in relapse; sister line of MOLT-4, suspension-growing, hypertetraploid, CD5/CD7 positive, DSMZ ACC 84 and ATCC CRL-1552.
MRC-5
MRC-5 is a human diploid cell line of lung fibroblasts derived in 1966, used as a substrate for producing viral vaccines and for isolating viruses from clinical specimens.
MT-2
MT-2 (CVCL_2631, also MT2, MT-2J) is a human T-cell line established in 1981 from male infant cord leukocytes co-cultured with adult T-cell leukemia cells; it produces HTLV-1 and serves as a standard donor line in HTLV-1 and HIV-1 research.
MT-4
MT-4 is a human T-cell line from an HTLV-1-infected Japanese man with adult T-cell leukemia that expresses HTLV-1 Tax and supports rapid HIV-1 replication, widely used in HIV-1 research and drug screening.
NCI-ADR-RES
NCI-ADR-RES (NCI/ADR-RES, formerly MCF-7/ADR; CVCL_1452) is a doxorubicin-resistant human ovarian cancer cell line derived from OVCAR-8, a member of the NCI-60 panel, long misidentified as a breast cancer subline.
NCI-H1092
NCI-H1092 is a human small cell lung cancer cell line established in June 1985 from a bone marrow metastasis in a 67-year-old male smoker, distributed by ATCC as CRL-5855.
NCI-H1105
NCI-H1105 (H1105, ATCC CRL-5856, CVCL_1455) is a human small cell lung cancer cell line established in 1985 from a metastatic lymph node of a 73-year-old male smoker; TP53 R249S, SCLC-A subtype.