400 articles
Karpas-231
Karpas-231 (KARPAS-231, CVCL_1822) is a human B-cell leukemia cell line from a 71-year-old woman, classified as diffuse large B-cell lymphoma, with POU2AF1-BCL6 fusion and MYC/BCL2 double-hit rearrangements.
Karpas-620
Karpas-620 (K620, CVCL_1823) is a human plasma cell leukemia cell line established in 1987 from a 77-year-old woman, IgG kappa-secreting, cyclin D1-expressing via der(8)t(8;11), with KRAS and TP53 mutations, used in myeloma drug screening.
KATO III
KATO III (KATO-III, JTC-28, CVCL_0371) is a human gastric signet ring cell carcinoma cell line from a 55-year-old male's pleural effusion, FGFR2/K-sam amplified, TP53 deleted, hypotetraploid, and widely used in gastric cancer drug research.
KD [Human lip fibroblast]
KD [Human lip fibroblast], synonym Karen Day, CVCL_2970/JCRB9103, a finite human lip fibroblast cell line from a 31-year-old female donor, used in DNA repair, transformation, and cleft lip research.
KG-1
KG-1 (CVCL_0374) is a human acute myeloid leukemia cell line established in 1978 by Koeffler and Golde from a 59-year-old man's bone marrow; its less differentiated subline KG-1a arose after 35 passages.
KM12
KM12 (KM-12, CVCL_1331) is a human colon carcinoma cell line, MSI-high, carrying a TPM3-NTRK1 fusion, entrectinib-sensitive, a member of the NCI-60 and DepMap panels, with WRN as its top dependency.
Ku812
Ku812 (KU812, KU-812, CVCL_0379) is a human chronic myeloid leukemia cell line from a 38-year-old man in blast crisis, the first human basophil cell line, Philadelphia chromosome and BCR-ABL1 b3a2 positive, bipotent with spontaneous erythroid differentiation.
Kuramochi
Kuramochi (KURAMOCHI, CVCL_1345, JCRB0098) is a human ovarian cancer cell line established in 1981 from ascites of a Japanese patient, used as a high-grade serous ovarian carcinoma model with TP53 D281Y and BRCA2 mutations.
KYSE-150
KYSE-150 (CVCL_1348, DSMZ ACC 375, JCRB1095) is a human esophageal squamous cell carcinoma cell line established by Shimada et al. in 1992 from a 49-year-old Japanese woman, widely used in radiation-resistance and drug studies.
KYSE-30
KYSE-30 (CVCL_1351) is a human esophageal squamous cell carcinoma cell line from a 64-year-old Japanese man, established 1992 in the KYSE series via nude-mouse heterotransplant; carries CDKN2A, HRAS Q61L, TP53 mutations and MYC, cyclin D1 amplifications.
L-363
L-363 (L363, CVCL_1357, DSMZ ACC 49) is a human plasma cell leukemia cell line established in 1977 from a 36-year-old woman, used as a multiple myeloma model with NRAS Q61H, PIK3CA E545K, and homozygous TP53 S261T mutations.
L-540
L-540 is a human cell line derived from a patient with Hodgkin lymphoma, established in 1981 by Volker Diehl at the University of Cologne and known for high CD30 expression.
LA-N-1
LA-N-1 (LAN-1, CVCL_1827) is a human neuroblastoma cell line established in 1977 from a bone marrow metastasis in a 2-year-old boy, carrying MYCN amplification and an ALK F1174L mutation.
LLC-MK2
LLC-MK2 (Lilly Laboratories Culture-Monkey Kidney 2), also written LLCMK2, is a spontaneously immortalized rhesus macaque kidney epithelial cell line established by Hull, Cherry, and Tritch at Lilly Research Laboratories (ATCC CCL-7, Cellosaurus CVCL_3009), widely used for virus isolation including parainfluenza, mumps, metapneumovirus, SARS-CoV, and SARS-CoV-2.
LLC-PK1
LLC-PK1, from Lilly Laboratories Culture-Porcine Kidney 1, is a pig kidney epithelial cell line developed in 1958 and used as a model of the renal proximal tubule.
LN-18
LN-18 (CVCL_0392, ATCC CRL-2610) is a human glioblastoma cell line established in 1976 from a right temporal lobe tumor of a male patient; TP53-mutant, CDKN2A-deleted, PTEN wild-type, temozolomide-resistant, authenticated by STR profiling.
LN-229
LN-229 (CVCL_0393, ATCC CRL-2611) is a human glioblastoma cell line established in 1979 from a 60-year-old female patient; adherent, TP53-mutant, PTEN wild-type, p16/p14ARF-deleted, tumorigenic in nude mice.
LNCaP
LNCaP (Lymph Node Carcinoma of the Prostate) is the most-used human prostate cancer cell line, derived from a lymph node metastasis; androgen-sensitive, AR- and PSA-positive, AR T878A mutant, PTEN-deficient.
LoVo
LoVo (LOVO) is a human colon adenocarcinoma cell line, CVCL_0399 / ATCC CCL-229, established from a supraclavicular lymph node metastasis in a 56-year-old man; MSI-high, KRAS G13D, CEA-producing metastasis model.
LS174T
LS174T (LS 174T, Laboratory of Surgery 174T, ATCC CL-188) is a human colon adenocarcinoma cell line derived in 1976 from a Dukes' type B tumor; a trypsinized LS180 variant, mucus- and CEA-secreting, MSI-high with KRAS G12D.
Lu-24
Lu-24 (NCC-c-Lu-24, CVCL_3349, RCB1771) is a human small cell lung carcinoma (oat cell) suspension cell line from a 42-year-old Japanese woman, established 1983, doubling time 102 hours, no reported TP53 mutation.
M-07e
M-07e (MO7e, Mo7e) is a human acute megakaryoblastic leukemia cell line, DSMZ ACC 104, established in 1987 from a 6-month-old girl; it is an IL-3/GM-CSF-dependent subline of M-07 used in cytokine and BCR-ABL studies.
MA-104
MA-104 (MA104) is an African green monkey fetal kidney epithelial cell line, originally mislabeled rhesus, that is highly susceptible to simian rotavirus SA11 and serves as the standard substrate for rotavirus isolation, assay, and vaccine research.
MAC-T
MAC-T (Mammary Alveolar Cells-large T antigen, CVCL_U226) is an immortalized bovine mammary epithelial cell line from a Holstein cow, SV-40 large T-antigen transfected at McGill in 1991, used for lactation and mammary biology studies.
Macrophage derived foam cell
Macrophage derived foam cell: a lipid-loaded macrophage, also called foam cell, formed by scavenger-receptor uptake of modified LDL and cholesteryl ester accumulation; hallmark of atherosclerosis, also seen in tuberculosis and other infections.
MCAS
MCAS (CVCL_3020) is a human ovarian mucinous cystadenocarcinoma cancer cell line established in 1985 from a 60-year-old Japanese woman, carrying KRAS G12D, CDKN2A, PIK3CA, SMAD4, and TP53 mutations and used as a mucinous ovarian carcinoma model.
MCF-10A
MCF-10A (Michigan Cancer Foundation-10A) is a non-tumorigenic, spontaneously immortalized human breast epithelial cell line isolated in 1984 from fibrocystic breast tissue, ATCC CRL-10317, used as a normal-like breast model and 3D acini culture system.
MCF-7
MCF-7 (Michigan Cancer Foundation-7, CVCL_0031, ATCC HTB-22) is the first hormone-responsive human breast adenocarcinoma cell line, established 1973 from a pleural effusion; ER-positive, luminal A, the most published breast cancer cell line, with documented inter-laboratory heterogeneity.
MDA-MB-231
MDA-MB-231 (MD Anderson-Metastatic Breast-231, RRID:CVCL_0062) is a triple-negative human breast adenocarcinoma cell line established in 1973 from a pleural effusion, widely used in metastatic breast cancer and drug screening research.
MDA-MB-361
MDA-MB-361 (ATCC HTB-27, CVCL_0620) is a human luminal B, ER+/HER2+ breast adenocarcinoma cell line established in 1978 from a brain metastasis of a 40-year-old woman, carrying PIK3CA and TP53 mutations.