25,729 articles
Clinical presentation of brain tumors
The clinical presentation of brain tumors is the symptoms and signs an intracranial mass produces, including headache, seizures, raised intracranial pressure, and focal deficits that reflect the tumor's location.
Clinical psychology review
Clinical Psychology Review (Clin Psychol Rev, ISSN 0272-7358) is an Elsevier review journal founded in 1981, publishing syntheses of clinical psychology research; 2025 impact factor about 11.2, ranked second in its category.
Clinical radiology
Clinical radiology: the imaging-based medical specialty, and the monthly Elsevier journal (ISSN 0009-9260, since 1960, formerly Journal of the Faculty of Radiologists) of the UK Royal College of Radiologists.
Clinical Relevance
Clinical relevance (clinical significance, clinical importance): criteria for whether a finding or treatment effect is large enough to matter for patient care, distinct from statistical significance; anchored by MCID, smallest worthwhile effect, and GRADE decision thresholds.
Clinical research
Clinical research studies people, their data, or tissue samples to understand health and disease. Covers observational studies and clinical trials, NIH trial definition, ICH E6(R3) GCP, ClinicalTrials.gov registration, and RCT versus observational evidence.
Clinical staging
Clinical staging is the classification of a cancer's extent by tumor size, lymph node involvement, and metastasis, using the TNM system, assigned before any definitive treatment to guide therapy and predict survival.
Clinical symptom
Clinical symptom: a subjective indication of disease felt and reported by the patient (pain, nausea, fatigue), contrasted with the objective clinical sign; classified in ICD-10-CM R00-R99 and ICD-11 Chapter 21.
Clinical transplantation
Clinical Transplantation (Clin Transplant) is a bimonthly peer-reviewed transplantation journal founded in 1987 in Copenhagen, now published online-only by Wiley, edited by Ron Shapiro, indexed in MEDLINE and Scopus (Q2).
Clinical trial
Clinical trial: a prospective study assigning human participants to health-related interventions (drugs, devices, behavioral treatments) to evaluate health outcomes; includes randomized controlled trials, phases I to IV, registration, and decentralized designs.
Clinical trial simulation
Clinical trial simulation is a modeling method in which virtual patients are generated, treated, and followed on a computer to predict how a planned trial would perform.
Clinical Trials Registry-India
The Clinical Trials Registry-India (CTRI) is a free, public registry of clinical trials conducted in India, launched in 2007 and managed by the ICMR in New Delhi.
Clinical variant galactosemia
Clinical variant galactosemia, also called variant galactosemia, is a GALT deficiency phenotype with 1-10% residual enzyme activity, often from the S135L variant, neonatal onset, autosomal recessive inheritance, and a better treated outlook than classic galactosemia.
ClinicalTrials.gov
ClinicalTrials.gov is a public website and database of clinical research studies and their results, maintained by the National Library of Medicine at the National Institutes of Health, launched in 2000 and listing over 604,000 studies worldwide.
Clinodactyly
Clinodactyly: congenital sideways curvature of a finger, usually the little finger, caused by a wedge-shaped middle phalanx; common in Down syndrome; treated by observation or osteotomy when curvature exceeds 30 degrees.
Clinodactyly of toes
Clinodactyly of toes (ICD-11 LB81.0, HPO HP:0001863) is a congenital curvature of a toe toward the big toe, caused by an asymmetric C-shaped physis or delta phalanx; usually cosmetic, rarely operated.
Clinoidectomy
Clinoidectomy, more precisely anterior clinoidectomy, is a neurosurgical operation that drills away the anterior clinoid process of the sphenoid bone to expose the paraclinoid internal carotid artery.
Clinton health care plan of 1993
The Clinton health care plan of 1993, formally the Health Security Act and nicknamed Hillarycare, was a proposal guaranteeing universal health coverage that died in Congress in 1994.
Clioquinol
Clioquinol (iodochlorhydroxyquin) is an 8-hydroxyquinoline derivative with antibacterial and anticandidal activity, used in topical skin preparations, best known for the SMON epidemic in Japan and later Alzheimer's disease research.
CLIP trial
CLIP trial (Community Level Interventions for Pre-eclampsia), NCT01911494: three cluster randomised trials in India, Pakistan, and Mozambique testing CHW-led, mHealth-guided pre-eclampsia care; no improvement in the primary composite outcome.
CLIPPERS
CLIPPERS (chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids) is a rare steroid-responsive CNS inflammatory disorder, first described in 2010, causing subacute brainstem symptoms with punctate gadolinium-enhancing pontine lesions on MRI.
Clitoral enlargement methods
Clitoral enlargement methods: testosterone therapy (mainly gender-affirming) grows the clitoris 1-3 cm over 1-2 years; topical DHT lacks approval; surgery reduces clitoromegaly.
Clitoral erection
Clitoral erection: engorgement of the clitoris during arousal via NO/cGMP/PKG activation of BK(Ca) channels in erectile tissue homologous to the penis, innervated by S2–S4 parasympathetic cavernous nerves.
Clitoral hood
Clitoral hood (prepuce of the clitoris): skin fold formed by the labia minora covering the glans clitoris; coverage varies widely; associated conditions include clitoral adhesions and phimosis.
Clitoral hood reduction
Clitoral hood reduction (hoodplasty) is an elective surgery removing excess prepuce tissue over the clitoris, usually with labiaplasty; techniques, anesthesia, risks like nerve damage, and satisfaction evidence.
Clitoridectomy
Clitoridectomy: surgical removal of the clitoris, in whole or part; WHO FGM type I, and a 19th-century Western medical operation for masturbation and hysteria, now replaced by nerve-preserving clitoroplasty.
CLL/SLL: relationship between chronic lymphocytic leukemia and small lymphocytic lymphoma
CLL and SLL are the same B-cell cancer, differing only in whether the malignant cells accumulate in the blood (CLL) or in lymph nodes (SLL).
Cln-081
CLN-081 (zipalertinib, TAS6417) is an oral, irreversible, EGFR ex20ins-selective tyrosine kinase inhibitor for NSCLC; REZILIENT1 showed 35.2% ORR, and FDA NDA review has a February 27, 2027 PDUFA date.
CLN1 disease
CLN1 disease (infantile neuronal ceroid lipofuscinosis, Santavuori-Haltia disease, infantile Batten disease) is an autosomal recessive lysosomal storage disorder from PPT1 deficiency, causing psychomotor regression, seizures, blindness by age 2, and early death; later-onset variants exist.
CLN10 disease
CLN10 disease (neuronal ceroid lipofuscinosis type 10, cathepsin D deficiency) is a rare autosomal recessive lysosomal storage disorder caused by CTSD mutations; the congenital form is the most severe NCL, with microcephaly, seizures, and death within hours to weeks of birth.
CLN11 disease
CLN11 disease (neuronal ceroid lipofuscinosis 11, NCL11) is a rare autosomal recessive Batten disease spectrum disorder caused by biallelic GRN mutations, causing seizures, retinitis pigmentosa, ataxia, and cognitive decline from about age 13 to 25; single-copy GRN carriers risk frontotemporal dementia instead.