25,729 articles
Imacor-1 study
Imacor-1 (NCT02770183) was a withdrawn Geneva observational study of post-cardiac-surgery myocardial stunning recovery measured with the ImaCor ClariTEE hTEE probe; enrolled 0 participants.
Imagabalin
Imagabalin (PD-0332334, PF-00195889) is Pfizer's discontinued oral α2δ calcium-channel ligand, a gabapentinoid β-amino acid tested in Phase 3 for generalized anxiety disorder; development ended in 2009 for lack of benefit over standard care, never approved.
Imagawa-Matsumoto syndrome
Imagawa-Matsumoto syndrome (IMMAS, SUZ12-related overgrowth syndrome, OMIM 618786) is a rare autosomal dominant PRC2-related overgrowth disorder caused by heterozygous SUZ12 variants, with fewer than 20 reported cases.
Image Enhancement
Image enhancement: improving picture quality via computer processing, digital filtering, contrast agents, and deep-learning denoising, chiefly in medical imaging; MeSH descriptor D007089, introduced 1973, distinct from image segmentation or diagnosis.
IMAGe syndrome
IMAGe syndrome (intrauterine growth restriction, metaphyseal dysplasia, adrenal hypoplasia congenita, genital anomalies; OMIM 614732) is a very rare maternally inherited gain-of-function CDKN1C disorder presenting at birth with growth restriction and adrenal insufficiency.
Image-guided biopsy
Image-guided biopsy is a procedure in which a needle is placed into a suspected lesion under real-time imaging, such as ultrasound or CT, to obtain cells or tissue for diagnosis.
Image-guided surgery
Image-guided surgery (IGS) is a set of surgical techniques that link preoperative CT or MRI scans to the patient's anatomy, displaying instrument position and trajectory during the operation.
Image-Guided Surgery Toolkit
The Image-Guided Surgery Toolkit (IGSTK) is an open source C++ library providing tracking, registration, and visualization components for image-guided surgery applications, led from Georgetown University and released in 2006.
Image-guided thermal ablation
Image-guided thermal ablation is a minimally invasive cancer treatment in which probes placed under ultrasound, CT, or MRI guidance destroy tumors with heat or cold.
Imagery rescripting
Imagery rescripting (ImRs) is a psychotherapy technique in which a patient recalls a distressing mental image, usually a memory, and imaginatively changes it with corrective information.
Imaginal exposure
Imaginal exposure is a psychotherapy technique in which a client repeatedly and vividly imagines a feared situation or trauma memory until anxiety and avoidance decline.
Imaginary friend
An imaginary friend, in developmental psychology an imaginary companion (IC), is a fictitious person, animal, or object created by a child, considered common healthy pretend play rather than a sign of disturbance.
Imaging Phantoms
An imaging phantom is a physical object or digital file engineered to mimic human tissue, used to test and calibrate medical imaging scanners against known reference values.
Imaging-based diagnostic criteria for polycystic kidney disease
Age-adjusted imaging criteria that diagnose or exclude autosomal dominant polycystic kidney disease using cyst counts on ultrasound or MRI, or kidney volume on MRI and CT.
Imam Khomeini Hospital
Imam Khomeini Hospital (مجتمع بیمارستانی امام خمینی), Tehran: public academic hospital complex of Tehran University of Medical Sciences, founded 1946, with Valiasr Hospital, the Cancer Institute, Iran's first hospital cancer registry, and about 1,100 beds.
Imatinib
Imatinib (Gleevec, Glivec, STI-571) is the first BCR-ABL tyrosine kinase inhibitor, FDA-approved in 2001 for CML and later Ph+ ALL, GIST, and other cancers; generic since 2016.
Imciromab pentetate
Imciromab pentetate (Myoscint, R11D10) is a murine Fab antibody fragment against cardiac myosin, DTPA-conjugated and indium-111 labeled for imaging myocardial infarction; FDA approved July 3, 1996, withdrawn 1999.
IMECA trial
IMECA trial (NCT04491110), a Spanish multicenter randomized single-blind trial by Andaluz Health Service testing 7 days of pre-bedtime preferred music versus educational audio in 76 family caregivers of home palliative cancer patients; music maintained PSQI sleep quality (p=0.006).
Imetelstat
Imetelstat (Rytelo, GRN163L) is a first-in-class oligonucleotide telomerase inhibitor by Geron, FDA-approved June 2024 for transfusion-dependent anemia in lower-risk MDS after ESA failure; dosed 7.1 mg/kg IV every 4 weeks.
IMFDHAC trial
IMFDHAC (NCT03753932), Impact of Fixed Dentures in Head and Neck Cancer, a Swedish Region Jönköping County trial (2013-2021, 64 participants) testing whether fixed dentures after radiotherapy improve oral health-related quality of life, wellbeing, and nutrition.
Imidafenacin
Imidafenacin (KRP-197/ONO-8025) is a selective M3 antimuscarinic for overactive bladder, dosed 0.1 mg twice daily, 57.8% oral bioavailability, ~3 h half-life, approved in Japan.
Imidapril
Imidapril (Tanatril) is a long-acting prodrug ACE inhibitor, activated to imidaprilat in the liver, used for hypertension, renal parenchymal hypertension, type 1 diabetic nephropathy, and chronic heart failure; first approved 1993.
Imiglitazar
Imiglitazar (TAK-559) is a Takeda dual PPARα/γ agonist (glitazar) for type 2 diabetes; phase 3 development was discontinued in 2004 after liver enzyme abnormalities, and it was never approved.
Iminoglycinuria
Iminoglycinuria (OMIM 242600) is a rare benign autosomal recessive renal tubular transport defect causing excess urinary glycine, proline, and hydroxyproline with normal plasma levels, mainly from SLC36A2 mutations.
Imipramine
Imipramine (Tofranil), the first tricyclic antidepressant, discovered by Roland Kuhn at Münsterlingen from Geigy compound G22355; FDA approved 1959; inhibits norepinephrine and serotonin reuptake; used for depression and childhood enuresis.
Imiquimod
Imiquimod (Aldara, Zyclara) is a topical imidazoquinoline immune response modifier and TLR7/8 agonist approved since 1997 for genital warts, actinic keratosis, and superficial basal cell carcinoma.
Imlifidase
Imlifidase (IdeS, Idefirix) is a recombinant Streptococcus pyogenes cysteine protease that cleaves all human IgG, conditionally EU-approved since 2020 to desensitize highly sensitized kidney transplant patients with positive crossmatch before deceased-donor transplantation.
IMM2510
IMM2510 (palverafusp alfa, AXN-2510) is ImmuneOnco's PD-L1 x VEGF bispecific antibody fusion protein using a VEGFR1 trap and ADCC-enhanced Fc; RP2D 20 mg/kg Q2W, tested in NSCLC, sarcoma, and TNBC.
IMM27M
IMM27M (tazlestobart) is ImmuneOnco's humanized Fc-engineered, ADCC-enhanced anti-CTLA-4 IgG1 antibody for advanced solid tumors; Phase I RP2D 5 mg/kg Q3W, formerly licensed to Instil Bio's Axion Bio outside Greater China.
IMMDC study
IMMDC (NCT04302363), Analysis of Intestinal Microflora Combined With DNA Methylation in Stool to Detect Colorectal Cancer, an observational case-control study at Xiangya Hospital, China, building a CRC screening model from 16S rRNA fecal microbiota plus exfoliated-cell DNA methylation in 500 participants.