72,234 articles
Mixed lesions of pinta
Mixed lesions of pinta (ICD-11 1C1E.3; ICD-10-CM A67.3), also called achromic and hyperchromic skin lesions of pinta, is a coding category for pinta, the Treponema carateum skin disease, when depigmented and hyperpigmented lesions coexist.
Mixed lymphocyte culture test
The mixed lymphocyte culture test, also called the mixed lymphocyte reaction, mixes lymphocytes from two people in culture to measure HLA class II mismatch, once used to select transplant donors.
Mixed neuroendocrine and non-neuroendocrine neoplasm of pancreas
Pancreatic MiNEN (mixed neuroendocrine-non-neuroendocrine neoplasm), formerly MANEC or mixed exocrine-endocrine carcinoma, is a rare (0.2% of pancreatic tumors) biphasic malignancy with neuroendocrine and ductal or acinar components each ≥30%, five-year survival about 40%.
Mixed rhinitis
Mixed rhinitis (ICD-11 CA08.2), also called mixed allergic and non-allergic rhinitis, is a chronic rhinitis subtype where allergic and non-allergic mechanisms coexist, affecting an estimated 30–50% of chronic rhinitis patients.
Mixed-phenotype acute leukemia
Mixed-phenotype acute leukemia (MPAL), also called biphenotypic or ambiguous-lineage leukemia, is a rare acute leukemia (2-5% of cases) with both ALL and AML features, treated mainly with ALL-like induction plus transplant.
Mixed-type autoimmune hemolytic anemia
Mixed-type autoimmune hemolytic anemia, or mixed AIHA, is a rare form of autoimmune hemolytic anemia where warm IgG and cold IgM autoantibodies together destroy red blood cells.
Mixer-wagon
Mixer-wagon (feed mixer wagon, diet feeder): trailer, truck-mounted, or self-propelled machine that weighs, cuts, mixes, and delivers total mixed rations to cattle; vertical, horizontal-auger, and reel types, 5–45 m³ chambers, mixing accuracy affects milk yield.
Mixotrophic dinoflagellate
Mixotrophic dinoflagellates are dinoflagellate protists combining photosynthesis with prey ingestion, via own plastids, kleptoplastidy, or endosymbionts; widespread, bloom-forming, and important in plankton succession and ocean carbon cycling.
Miyoshi myopathy
Miyoshi myopathy (MMD1, Miyoshi distal myopathy) is an autosomal recessive distal muscular dystrophy from DYSF mutations, causing calf weakness beginning at 15-30 years; it is the same disease as LGMDR2 (dysferlinopathy).
Mizan al-Tibb
米扎尼·提比 (Mīzān al-ṭibb, ميزان الطب), "The Measure of Medicine," is a Persian Unani medical handbook by Mughal physician Muhammad Akbar Arzani, a foundational 18th-century student textbook now cited in China's Uyghur classic formula directory.
Mizolastine
Mizolastine (Mizollen, Mizolastin) is a second-generation benzimidazole H1 antihistamine, 10 mg once daily for allergic rhinitis and chronic idiopathic urticaria, approved in Europe in 1998, with no demonstrated QTc prolongation but updosing not recommended.
Mizuhopecten yessoensis
Mizuhopecten yessoensis (Yesso scallop, Japanese scallop, hotate-gai; syn. Patinopecten yessoensis) is a cold-water pectinid bivalve of the North Pacific, Sea of Okhotsk, and Sea of Japan, farmed heavily in Japan, China, and Korea; tolerates −2 to 26 °C with optimal growth at 4–8 °C and faces francisellosis and heatwave mortality.
Mk-3415
Mk-3415 (actoxumab, CDA1/GS-CDA1) is Merck's fully human monoclonal antibody against C. difficile toxin A; it failed phase 3 MODIFY trials, its arm stopped for safety, and only bezlotoxumab (MK-6072) was approved.
Mkhitar Heratsi
Mkhitar Heratsi (Մխիթար Հերացի, c. 1120, Her, now Khoy in Iran – 1200) was a medieval Armenian physician, founder of the Armenian classical and Cilician medical schools and author of Consolation of Fevers.
MKN1
MKN1 (MKN-1, CVCL_1415) is a human gastric adenosquamous carcinoma cell line established in 1977 from a lymph node metastasis of a 72-year-old Japanese man, carrying a TP53 Val143Ala mutation, E-cadherin promoter hypermethylation, and MSS status.
MKN28
MKN28 (MKN-28, CVCL_1416) is a human gastric tubular adenocarcinoma cell line from a Japanese male's liver metastasis, used as a well-differentiated, EGFR-high, MSS gastric cancer model, but shown to be an MKN74 derivative and listed by ICLAC as misidentified.
MKN45
MKN45 (MKN-45, CVCL_0434) is a human diffuse-type gastric adenocarcinoma cell line from a liver metastasis in a 62-year-old Japanese woman, MET-amplified, microsatellite stable, adherent, and widely used in gastric cancer research.
MKN74
MKN74 (MKN-74, CVCL_2791) is a human gastric tubular adenocarcinoma cell line from a liver metastasis in a 37-year-old Japanese male, intestinal-type, wild-type or mutant p53 reports, doubling time about 44 hours.
MKNK1
MKNK1 (MNK1) is a human gene at 1p33 encoding a serine/threonine kinase activated by ERK and p38 MAPKs that phosphorylates eIF4E at Ser209 via eIF4G docking, regulating translation, inflammation, and cancer; targeted by inhibitors such as tomivosertib.
ML-2
ML-2 (ML2, CVCL_1418, DSMZ ACC-15) is a human acute myelomonocytic leukemia (AML M4) cell line established in 1978 from a 26-year-old man, carrying t(6;11) KMT2A-AFDN fusion and heterozygous KRAS Ala146Thr; sister lines ML-1 and ML-3.
MLH1
MLH1, or mutL homolog 1, is a human gene on chromosome 3 whose protein repairs DNA replication errors; inherited variants cause Lynch syndrome, a hereditary cancer predisposition.
MLKL
MLKL (mixed lineage kinase domain-like pseudokinase) is the terminal effector of necroptosis: RIPK3 phosphorylates it, it oligomerizes and forms membrane pores. Also has non-necroptotic organelle and leukemia functions.
MLS study
MLS study, the Maternal Lifestyle Study (NCT00059540), a 1993-2011 US NICHD Neonatal Research Network observational cohort following 1,388 children prenatally exposed to cocaine or opiates to age 16.
MLXIPL
MLXIPL (ChREBP, MondoB, WBSCR14) is a human gene on chromosome 7q11.23 encoding a glucose-responsive bHLH/LZ transcription factor that heterodimerizes with MLX to regulate glycolytic and lipogenic genes, with alpha and beta isoforms and triglyceride and diabetes associations.
MM1.S
MM1.S, also written MM.1S, is a human multiple myeloma cell line, derived from plasma cells, used widely in myeloma research and known for dexamethasone sensitivity.
MM200
MM200 (CVCL_C836) is a human primary melanoma cell line from a 43-year-old female skin donor, carrying BRAF V600E and PTEN mutations, wild-type p53, and used widely in melanoma apoptosis, drug resistance, and immunotherapy research.
MM96
MM96 (CVCL_D848, RRID:CVCL_D848) is a human melanoma cancer cell line from a metastatic lymph node of a 66-year-old female, BRAF V600E positive, parent of the amelanotic subline MM96L.
MMCS trial
MMCS trial (NCT04442672), a completed 2019 interventional study by Zhejiang University's Second Affiliated Hospital, tested tissue oxygen, ultrasound Doppler, thermography, and pulse oximetry against cuff-induced calf pressure in healthy volunteers.
MMP10
MMP10 (stromelysin-2, transin-2; UniProt P09238, 11q22.2) is a secreted human matrix metalloproteinase degrading fibronectin, laminin, and collagens III-V, expressed in keratinocytes and macrophages, active in wound healing, immunity, and cancer, and distinct from its closest relative MMP3.
MMP12
MMP12 (macrophage metalloelastase, MMP-12, EC 3.4.24.65) is a human chromosome 11q22.2 gene encoding a zinc-dependent matrix metalloproteinase from macrophages that degrades elastin; linked to COPD, asthma, atherosclerosis, and aneurysm.